The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Impaired Iron Status in Aging Research
Open accessAbstract
Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
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“Age-dependent accumulation of iron in various tissues has been reported to occur separately to the enrichment of senescent cells [11], [12], [16], [17], [18], [19].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [12]
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“Conceivably, senescent cells account for the increased iron observed in aged tissues [11], [12] and similarly in organs affected by age-related pathologies [13], [14], [15].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [12]
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Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
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- (1995). Nutrient Requirements of Laboratory Animals, National Academy Press. [4th ed].
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Dysregulated iron metabolism in remodeling of aging asthmatic human airways
Ngassie, M. L. K., Ortiz, Y., Ravi, P., Pfeffer-Kleemann, D., Hamrick, S. K., Thompson, M. A., Fang, Y. H., Pabelick, C. M., & Prakash, Y. S. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00897.2025
Cellular senescence is associated with age-related loss of liver zonation and hepatocyte functionPreprint
Laux, L., Aristel, A., Ali, S., Lande, K., Li, M., Evensen, K. G., Havas, A. P., Miao, Z., Zhang, J., Peters, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.08.743614
Prieto, I. S., Garcés, J. M. O., Fernández-Ruanova, B., Tenorio‐Laranga, J., & Olabarria, I. V. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1917665
Metadata
- Authors
- Xu, J., Jia, Z., Knutson, M. D., & Leeuwenburgh, C.
- Affiliations
- University of Florida (US)
- Corresponding author
- Xu, Jinze
- Leeuwenburgh, Christiaan
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2012-02-22
- Volume
- 13
- Issue
- 2
- Pages
- 2368-2386
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3292028
- OpenAlex
- W2144968983
- Cited by
- 103
- References
- 127
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 2
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Heart Association
- University of Florida (P30 AG028740)
- National Institutes of Health (UL1TR000064, DK080706)
- National Institute on Aging (R01AG017994, P30AG028740)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080706)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- iron metabolism, iron dyshomeostasis, aging, age-related diseases, iron chelation, iron storage, rodent models, cellular and molecular mechanisms
- MeSH terms
- Aging, Animals, Disease Models, Animal, Health Status, Humans, Iron, Mitochondria, Rodentia, Iron Metabolism Disorders
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