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Impaired Iron Status in Aging Research

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Xu, Jinze, Jia, Zhenhua, Knutson, Mitchell D., Leeuwenburgh, Christiaan·2012·International Journal of Molecular Sciences

DOI 10.3390/ijms13022368PMC PMC3292028

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Abstract

Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.

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Authors: Xu, J., Jia, Z., Knutson, M. D., & Leeuwenburgh, C.
Affiliations: University of Florida (US)
Corresponding author: Xu, Jinze
Leeuwenburgh, Christiaan
ORCID: Jia, Zhenhua
Knutson, Mitchell D.
Leeuwenburgh, Christiaan
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2012-02-22
Volume: 13
Issue: 2
Pages: 2368-2386
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms13022368
PMC: PMC3292028
OpenAlex: W2144968983
Cited by: 103
References: 127
Citations by year: 2026: 5 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 2
FWCI: 0.96
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: American Heart Association
University of Florida (P30 AG028740)
National Institutes of Health (UL1TR000064, DK080706)
National Institute on Aging (R01AG017994, P30AG028740)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080706)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: iron metabolism, iron dyshomeostasis, aging, age-related diseases, iron chelation, iron storage, rodent models, cellular and molecular mechanisms
MeSH terms: Aging, Animals, Disease Models, Animal, Health Status, Humans, Iron, Mitochondria, Rodentia, Iron Metabolism Disorders

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