The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Sequence and organization of the human mitochondrial genome

Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,740

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989

Free radicals, metals and antioxidants in oxidative stress-induced cancer

Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680

Oxygen toxicity, oxygen radicals, transition metals and disease

Halliwell, B., & Gutteridge, J. M. C. (1984) · Biochemical Journal · doi:10.1042/bj2190001 · Cited by 5,330

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227

Mitochondrial formation of reactive oxygen species

Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: Synthesis, biological evaluation, and molecular modeling studies

Buemi, M. R., Luca, L. D., Chimirri, A., Ferro, S., Gitto, R., Álvarez‐Buílla, J., & Alajarı́n, R. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.05.044 · Cited by 20

A Comprehensive Review on Preclinical Evidence-based Neuroprotective Potential of Bacopa monnieri against Parkinson's Disease

Goyal, A., Gopika, S., Kumar, A., & Garabadu, D. (2022) · Current Drug Targets · doi:10.2174/1389450123666220316091734 · Cited by 20

Need for considering urban climate change factors on stroke, neurodegenerative diseases, and mood disorders studies

Tewari, K., Tewari, M., & Niyogi, D. (2023) · Computational Urban Science · doi:10.1007/s43762-023-00079-w · Cited by 19

Free water and iron content in the substantia nigra at different stages of Parkinson's disease

Chen, M., Wang, Y., Zhang, C., Li, J., Li, Z., Guan, X., Bao, J., Zhang, Y., Cheng, J., & Wei, H. (2023) · European Journal of Radiology · doi:10.1016/j.ejrad.2023.111030 · Cited by 19

Chemical profiling, free radical scavenging and anti-acetylcholinesterase activities of essential oil from curcuma caesia of Arunachal Pradesh, India

Sharma, H. K., Borah, S., & Sarkar, P. (2020) · Pharmacognosy Research · doi:10.4103/pr.pr_84_19 · Cited by 20

Neuropathological changes in wild muskrats (Ondatra zibethicus) and red squirrels (Tamiasciurus hudsonicus) breeding in arsenic endemic areas of Yellowknife, Northwest Territories (Canada): Arsenic and cadmium accumulation in the brain and biomarkers of oxidative stress

Amuno, S. A., Shekh, K., Kodzhahinchev, V., & Niyogi, S. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135426 · Cited by 18

Effect of Cooking Method on Vitamin C Loses and Antioxidant Activity of Indigenous Green Leafy Vegetables Consumed in Western Uganda

Kinyi, H. W., Tirwomwe, M., Ninsiima, H. I., & Miruka, C. O. (2022) · International Journal of Food Science · doi:10.1155/2022/2088034 · Cited by 18

Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol induced parkinson’s disease in rat

Vannur, A., Biradar, P. R., & Patil, V. S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-021-00878-2 · Cited by 19

Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats

Jiménez-Martín, J., Blanco-Lezcano, L., González-Fraguela, M. E., Díaz-Hung, M. L., Serrano-Sánchez, T., Almenares, J. L., & Turner, L. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.12.056 · Cited by 18

Adiponectin offers protection against L166P mutant DJ-1-induced neuronal cytotoxicity mediated by APPL1-dependent AMPK activation

Li, X., Geng, J., & Liu, J. (2013) · International Journal of Neuroscience · doi:10.3109/00207454.2013.846340 · Cited by 18

The neuroprotective effects of melatonin against diabetic neuropathy: A systematic review of non-clinical studies

Hosseini, A., Samadi, M., Baeeri, M., Rahimifard, M., & Haghi‐Aminjan, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.984499 · Cited by 18

A Pharmacological Appraisal of Neuroprotective and Neurorestorative Flavonoids Against Neurodegenerative Diseases

Zhao, J., Zhu, M., Kumar, M., Ngo, F. Y., Li, Y., Lao, L., & Rong, J. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666181105093834 · Cited by 17

Aberrant Free Radical Biology Is a Unifying Theme in the Etiology and Pathogenesis of Major Human Diseases

Domann, F. E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14048491 · Cited by 17

Insecticidal activity and systematic insights of carvacrol against Tribolium castaneum: Acetylcholinesterase inhibition, oxidative stress, and molecular docking"

Eltalawy, H. M., El‐Fayoumi, H., Aboelhadid, S. M., Al-Quraishy, S., El-Mallah, A.-M., El‐Ela, F. I. A., Awad, E. M., & Abdel‐Baki, A. S. (2025) · Journal of Stored Products Research · doi:10.1016/j.jspr.2025.102638 · Cited by 18

Gut neurotoxin p-cresol induces brain-derived neurotrophic factor secretion and increases the expression of neurofilament subunits in PC-12 cells

Tevzadze, G., Barbakadze, T., Kvergelidze, E., Zhuravliova, E., Shanshiashvili, L., & Mikeladze, D. (2021) · AIMS neuroscience · doi:10.3934/neuroscience.2022002 · Cited by 17

Cell-Type-Specific Mitochondrial Quality Control in the Brain: A Plausible Mechanism of Neurodegeneration

Ragupathy, H., Vukku, M., & Barodia, S. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914421 · Cited by 16

Potential molecular mechanisms mediating the protective effects of tetrahydroxystilbene glucoside on MPP+-induced PC12 cell apoptosis

Zhang, L., Huang, L., Li, X., Liu, C., Sun, X., Wu, L., Li, T., Yang, H., & Chen, J. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3169-8 · Cited by 16

Protection from the Pathogenesis of Neurodegenerative Disorders, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis, Huntington’s Disease, and Parkinson’s Diseases, through the Mitigation of Reactive Oxygen Species

Madireddy, S., & Madireddy, S. (2019) · Journal of Neuroscience and Neurological Disorders · doi:10.29328/journal.jnnd.1001026 · Cited by 16

Estrogen Up-Regulates Iron Transporters and Iron Storage Protein Through Hypoxia Inducible Factor 1 Alpha Activation Mediated by Estrogen Receptor β and G Protein Estrogen Receptor in BV2 Microglia Cells

Qu, Y., Li, N., Xu, M., Zhang, D., Xie, J., & Wang, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03658-1 · Cited by 16

Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis

Chen, Y.-Y., Tsai, C.-F., Tsai, M.-C., Hsu, Y., & Lu, F. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2017.05.008 · Cited by 15

Redox modulatory role of DJ-1 in Parkinson’s disease

Alshammari, Q. A. (2025) · Biogerontology · doi:10.1007/s10522-025-10227-w · Cited by 15

CSF Nrf2 and HSPA8 in Parkinson’s disease patients with and without LRRK2 gene mutations

Loeffler, D. A., Smith, L. M., Coffey, M. P., Aasly, J. O., & LeWitt, P. A. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1479-0 · Cited by 14

Selenoprotein P Modulates Methamphetamine Enhancement of Vesicular Dopamine Release in Mouse Nucleus Accumbens Via Dopamine D2 Receptors

Torres, D. J., Yorgason, J. T., Mitchell, C. C., Hagiwara, A., Andres, M. A., Kurokawa, S., Steffensen, S. C., & Bellinger, F. P. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.631825 · Cited by 14

Differential regulation of HIF-3α in LPS-induced BV-2 microglial cells: Comparison and characterization with HIF-1α

Kumar, H., Lim, J.-H., Kim, I., & Choi, D. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.046 · Cited by 13

Decrease in Oxidative Stress Parameters after Post‐Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia

Mršić‐Pelčić, J., Pilipović, K., Pelčić, G., Vitezić, D., & Župan, G. (2017) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12833 · Cited by 13

Chemical composition, antioxidant, and anticholine esterase activities of essential oil of xylopia aethiopica seeds

Sulaimon, L. A., Adisa, R. A., Obuotor, E. M., Lawal, M. O., Moshood, A., & Muhammad, N. (2020) · Pharmacognosy Research · doi:10.4103/pr.pr_47_19 · Cited by 13

Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice

Badinter, F., Amit, T., Bar‐Am, O., Youdim, M. B. H., & Weinreb, O. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.05.041 · Cited by 12

Injury factors and pathological features of toxic milk mice during different disease stages

Zhou, X., Li, X., Chen, D., Wu, C., Feng, L., Qin, H., Pu, X., & Liang, X. (2019) · Brain and Behavior · doi:10.1002/brb3.1459 · Cited by 12

Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats

Banu, M. R., Ibrahim, M., Prabhu, K., & Rajasankar, S. (2019) · Cells Tissues Organs · doi:10.1159/000505183 · Cited by 12

New benzimidazole-aldehyde hybrids as neuroprotectors with hypochlorite and superoxide radical-scavenging activity

Anastassova, N., Yancheva, D. Y., Hristova-Avakumova, N. G., Hadjimitova, V. A., Traykov, T. T., Aluani, D., Tzankova, V., & Kondeva-Burdina, M. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00077-3 · Cited by 12

Three ‐(pyridin‐2‐yl)‐2‐(pyridin‐2‐ylimino)thiazolidin‐4‐one as a novel inhibitor of cerebral MAO‐B activity with antioxidant properties and low toxicity potential

Júnior, L. R. C., Alves, A. G., Rech, T. D. S. T., Campos, J. C., Siqueira, G. M., Cunico, W. J., Brüning, C. A., & Bortolatto, C. F. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22833 · Cited by 11

Changes in iron load in specific brain areas lead to neurodegenerative diseases of the central nervous system

Wang, X., Zhu, Z., Sun, J., Li, J., Cai, L., Chen, Q., Yang, W., Wang, Y., Zhang, Y., Guo, S., et al. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110903 · Cited by 9

Carnosine supplementation improves cognitive outcomes in younger participants of the NEAT trial

O’Toole, T. E., Amraotkar, A. R., Gao, H. T., Sears, C. G., Rai, S. N., Basner, M., & Bhatnagar, A. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00541 · Cited by 9

Effects of radiation exposure on brain health: a state of the art and new challenges

Jayan, J., Roshi, H., Ashraf, F. F. P., Nair, P. G., Vijayakumar, A., Nair, A. S., Pappachen, L. K., Abdelgawad, M. A., Parambi, D. G. T., Aleya, L., et al. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-23703-4 · Cited by 9

Assessing neuroprotective efficacy of phytochemical saponin ruscogenin in both in vitro and in vivo model

Wu, Q., Wang, M., Chen, W., Wang, K., & Wang, Y. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104693 · Cited by 9

Changes to Intermediary Metabolites in Sporadic andLRRK2Parkinson’s Disease Demonstrated by Proton Magnetic Resonance Spectroscopy

Aasly, J. O., Sæther, O., Johansen, K. K., Bathen, T. F., Giskeødegård, G. F., & White, L. R. (2015) · Parkinson s Disease · doi:10.1155/2015/264896 · Cited by 9

Hesperetin protects SH-SY5Y cells against 6- hydroxydopamine-induced neurotoxicity via activation of NRF2/ARE signaling pathways

Li, J., Liu, Y., Wang, L., Gu, Z., Huan, Z., Fu, H., & Liu, Q. (2020) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v19i6.12 · Cited by 9

Neuroprotective effects of flavonoids

Taghizadieh, M., Modiri, N., Salmaninejad, A., Khayami, R., Taheri, F., Moghoofei, M., Khatami, A., Azhdari, S., Bayat, M., Samadi-khouzani, A., et al. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824467-8.00016-4 · Cited by 8

Theoretical study of the antioxidant capacity of polyphenols against the DPPH radical. An approach from the spin – Polarized density functional theory (SP – DFT)

Muñoz-Espinoza, J., & Barriga-González, G. (2025) · Chemical Physics Letters · doi:10.1016/j.cplett.2025.142105 · Cited by 8

Insights from multi-omic modeling of neurodegeneration in xeroderma pigmentosum using an induced pluripotent stem cell system

Badja, C., Momen, S., Koh, C. C., Boushaki, S., Roumeliotis, T. I., Kozik, Z., Jones, I., Bousgouni, V., Dias, J. M. L., Krokidis, M. G., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114243 · Cited by 9

ANTIOXIDANT STUDIES ON METHANOL AND AQUEOUS EXTRACTS OF GYMNOSPORIA MONTANA PLANT

Ansari, N., & Chandel, D. (2018) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2019v11i2.30883 · Cited by 8

Oxidative Stress and Its Modulation by Ladostigil Alter the Expression of Abundant Long Non-Coding RNAs in SH-SY5Y Cells

Zohar, K., Giladi, E., Eliyahu, T., & Linial, M. (2022) · Non-Coding RNA · doi:10.3390/ncrna8060072 · Cited by 9

In situ measurement of superoxide and hydroxyl radicals by frequency mixing detection technique

Hong, H., Krause, H., Sohn, S., Baik, T., Park, J. H., Shin, S.-W., Park, C., & Song, D. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.11.009 · Cited by 8

Hepatoprotective Effects of Xylose-Taurine Reduced Against Hydrogen Peroxide-Induced Oxidative Stress in Cultured Hepatocytes

Park, S. Y., Ahn, C., Chang, K. J., Kim, S. H., Lee, W., Um, J. H., Han, E. J., Jeon, Y., Cheong, S. H., & Ahn, G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1079-2_48 · Cited by 8

Study on different pathogenic factors in different disease stages of patients with Wilson disease

Zhou, X., Xiao, X., Qin, H., Chen, D., & Wu, C. (2021) · Neurological Sciences · doi:10.1007/s10072-020-04973-7 · Cited by 8

The Common Alzheimer's Disease Research Ontology (CADRO) for biomarker categorization

Osse, A. M. L., Kinney, J. W., & Cummings, J. L. (2025) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70050 · Cited by 7

Comparative Pharmacognostical Studies of Blue and White Flower Varieties of Clitoria ternatea l.

Khatoon, S., & Irshad, S. (2016) · Journal of Pharmacognosy & Natural Products · doi:10.4172/2472-0992.1000109 · Cited by 7

Neostigmine treatment induces neuroprotection against oxidative stress in cerebral cortex of asthmatic mice

Antunes, G. L., Silveira, J. S., Kaiber, D. B., Luft, C., dos Santos, T. M., Marques, E. P., Ferreira, F. S., Schmitz, F., Wyse, Â. T. D. S., Stein, R. T., et al. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00558-7 · Cited by 7

The Interplay of Carveol and All-Trans Retinoic Acid (ATRA) in Experimental Parkinson’s Disease: Role of Inflammasome-Mediated Pyroptosis and Nrf2

Muhammad, A. J., Albaqami, F. F., Alanazi, F. E., Alattar, A., Alshaman, R., Rehman, N. U., Riadi, Y., & Shah, F. A. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04226-5 · Cited by 6

Isolation and Characterization of NP‐POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease

Lemieszewska, M., Polanowski, A., Wilusz, T., Sokołowska, A., Zambrowicz, A., Mikołajewicz, K., Macała, J., Rymaszewska, J., & Zabłocka, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3760124 · Cited by 6

Exploring the Potential of Indole-3-acetic Acid Arylhydrazone Hybrids for Parkinson’s Disease Treatment: A Comprehensive Evaluation of Neuroprotective, MAOB Inhibitory, and Antioxidant Properties

Anastassova, N., Kondeva-Burdina, M., Hristova-Avakumova, N. G., Stefanova, D., Rangelov, M. A., Todorova, N. H., & Yancheva, D. Y. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00838 · Cited by 5

Development of Gelatin-Alginate-TiO2-SOD Biosensor for the Detection of Superoxide Radicals

Karakaya, U., Derkuş, B., & Emregül, E. (2020) · Journal of the Turkish Chemical Society Section A Chemistry · doi:10.18596/jotcsa.646433 · Cited by 6

Cognitive Performance is Associated with Altered Cerebral Hemodynamics Assessed by Transcranial Ultrasound in Parkinson’s Disease

Ge, Y.-L., Gong, S., Wang, P.-Z., Yan, J.-H., Li, W., Zhang, J., Jin, H., Zhuang, S., Hu, L., Ding, C., et al. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s358150 · Cited by 5

Antioxidant and Neuroprotective Effect of Organic and Conventional White Grape Juices on Oxidative Stress Induced by Sodium Azide in Cerebral Cortex of Rats

Ongaratti, B. R., Machado, F. D. S., Medeiros, N. D. S., Destri, C., da Silva, E., Quincozes‐Santos, A., Dani, C., & Funchal, C. (2014) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2014/8470 · Cited by 5

A Review on Ethnomedicinal, Phytochemistry and Pharmacological Activities of Rumex hastatus D. Don

Hassan, I., Mushtaq, I., Raja, W. Y., & Bhat, Z. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-4959-2_6 · Cited by 5

Antioxidants: Balancing the Good, the Bad and the Ugly

Majeed, M. A. (2016) · Nutrition and Food Technology Open Access · doi:10.16966/2470-6086.123 · Cited by 5

Potential of Hesperidin in the Medicinal Field

Kumar, D., Dey, Y. N., Pramanik, S. D., Singh, L. P., Selvaraja, M., & Rajagopal, M. S. (2022) · Current Bioactive Compounds · doi:10.2174/1573407219666221020101834 · Cited by 4

Extraction optimization of anti-Parkinson’s medication L-DOPA and bioactive compounds from Mucuna atropurpurea (Roxb.) Wight & Arn. with biomedical potential: RSM based desirability function approach

Mali, P., Kamble, P. P., Aware, C. B., Suryawanshi, S. S., & Jadhav, J. P. (2022) · Journal of Applied Research on Medicinal and Aromatic Plants · doi:10.1016/j.jarmap.2022.100451 · Cited by 4

Myrtenol‐Loaded Fatty Acid Nanocarriers Protect Rat Brains Against Ischemia–Reperfusion Injury: Antioxidant and Anti‐Inflammatory Effects

Afshar, S. K., Rostamzadeh, F., Bigdeli, M. R., & Moghadam, F. M. (2024) · Chemical Biology & Drug Design · doi:10.1111/cbdd.14633 · Cited by 4

Chronic consumption of cassava juice induces cellular stress in rat substantia nigra.

Rosas-Jarquín, C. D. J., Rivadeneyra-Domínguez, E., León‐Chávez, B. A., Nadella, R., Sánchez-García, A. D. C., Rembao‐Bojórquez, D., Rodríguez‐Landa, J. F., & Hernández-Baltazar, D. (2020) · PubMed Central · doi:10.22038/ijbms.2019.38460.9131 · Cited by 4

Polyphenol-modified nanovesicles for synergistically enhanced in vitro tumor cell targeting and apoptosis

Seo, J., Kim, S., Lee, Y., Kim, J., Lee, Y., Shin, M., & Kim, J. W. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02509k · Cited by 4

Potential Diagnostic Significance of Salivary Copper Determination in Breast Cancer Patients: A Pilot Study

Bel’skaya, L. V., Sarf, E. A., Петрович, Ш. С., Postnova, T. V., & Kosenok, V. K. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02710-5 · Cited by 4

Alteration in Long Noncoding RNAs in Response to Oxidative Stress and Ladostigil in SH-SY5Y CellsPreprint

Zohar, K., Giladi, E., Eliyahu, T., & Michal Linial, B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.20.481187 · Cited by 4

Mechanistic insights into Alpha-Synuclein binding to P2RX7: A molecular dynamic and docking study

Kumar, M., Singh, K., Joshi, J., Sharma, S., Kumar, A., Irungbam, K., Mahawar, M., & Saini, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319098 · Cited by 3

The Aging Brain

Rajput, R., Kaur, R., Chadha, R., Mani, S., Rachana, R., Kaur, H., & Singh, M. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-5282-6.ch001 · Cited by 4

Polyphenols as Potential Therapeutic Drugs in Neurodegeneration

de Laureto, P. P., Palazzi, L., & Acquasaliente, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89575 · Cited by 3

Study of the potential toxicity of adrenaline to neurons, using the SH-SY5Y human cellular model

Costa, V. M., Capela, J. P., Bastos, M. D. L., Remião, F., Varner, K. J., Duarte, J. A., & Carvalho, F. D. (2023) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902023e20467 · Cited by 3

The Flavonoids Ameliorates: Protective Mechanisms in Neurodegenerative Diseases

Gupta, J., Gupta, A. K., & Gupta, A. K. (2017) · International Journal of Current Research in Chemistry and Pharmaceutical Sciences · doi:10.22192/ijcrcps.2017.04.01.001 · Cited by 3

Melatonin in Aging and Aging-Related Disorders

Süzen, S. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_9 · Cited by 3

Anticancer and Apoptosis Inducing Effect of Methanolic Extract of Leaves and Rhizomes of Curcuma amada Roxb in Breast Cancer Cell Lines

Sivaprabha, J. (2014) · Shodhganga · Cited by 3

Effects of Perilla Seed Pomace Extract on Aging-Induced Cognitive Dysfunction in SAMP8 Mice

Lee, H., Ha, T. Y., Kim, Y. T., & Um, M. Y. (2025) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2502.02007 · Cited by 2

Emphasizing the role of oxidative stress and Sirt-1/Nrf2 and TLR-4/NF-κB in Tamarix aphylla mediated neuroprotective potential in rotenone-induced Parkinson’s disease: In silico and in vivo study

Abu‐Baih, D. H., Elmaidomy, A. H., Abou‐Zied, H. A., Hussien, N. N., Rasekh, M. I., Saber, E. A., Ali, S. F. E.-S., Rateb, M. E., Hendawy, O. M., Altemani, F. H., et al. (2026) · PLoS ONE · doi:10.1371/journal.pone.0339010 · Cited by 3

Oxidative Stress—Related Serum Extracellular Vesicle miRNAs Indicate Symptom Severity and Cognitive Decline in Parkinson's Disease

Belickienė, V., Pranckevičienė, A., Radžiūnas, A., Strigauskaitė, A., Laucius, O., & Vaitkienė, P. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70355 · Cited by 2

Parkinson’s Disease: A Comprehensive Overview of the Disease

Khatib, A. J. A. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.109437 · Cited by 2

Histogram analysis of diffusion kurtosis imaging of deep brain nuclei in Parkinson's disease with different motor subtypes

Wang, J., Bi, Q., Gong, W., Zhang, H., Deng, M., Chen, L., & Wang, B. (2023) · Clinical Radiology · doi:10.1016/j.crad.2023.09.008 · Cited by 2

Neuroprotective effects of rosemary extract on white matter of prefrontal cortex in old rats.

Farsani, M. E., Razavi, S., Rasoolijazi, H., Esfandiari, E., Seyedebrahimi, R., & Ababzadeh, S. (2024) · PubMed Central · doi:10.22038/ijbms.2023.74168.16117 · Cited by 2

Nrf2 Signaling: An Adaptive Response Pathway for Neurodegenerative Disorders

Gerfo, A. L., Petrozzi, L., Chico, L., & Siciliano, G. (2016) · InTech eBooks · doi:10.5772/65300 · Cited by 2

The theory of free radicals and aging: A review article

Afshar, P. F. (2020) · Journal of Gerontology · doi:10.29252/joge.4.3.8 · Cited by 2

The role of cyclophilin A and VEGF in the pathogenesis and recurrence of pterygium

Turan, M., Turan, G., & Can, H. Y. (2022) · European Journal of Ophthalmology · doi:10.1177/11206721221128664 · Cited by 2

EFFECT OF RADIATION ON AGING PROCESSES AND TELOMERE LENGTH

Dondoladze, K., Nikolaishvili, M., Museliani, T., & Jikia, G. (2022) · Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology · doi:10.33145/2304-8336-2022-27-107-119 · Cited by 3

Exploring Novel Therapeutic Avenues: Drug Repurposing for Neurodegenerative Movement Disorders

Bassi, P., Rana, S., Sapra, V., Raina, A., Kumar, P., & Devi, S. (2024) · Current Drug Research Reviews · doi:10.2174/0125899775327220240822111611 · Cited by 1

Mitochondrial dysfunction alters early endosome trafficking via microtubule reorganization

Vishwakarma, A., Chihki, L., Todkar, K. J., Ouellet, M., & Germain, M. (2025) · Life Science Alliance · doi:10.26508/lsa.202403020 · Cited by 1

Control of Autophagy in Parkinson’s Disease

González‐Polo, R. A., Gómez‐Sánchez, R., Pizarro‐Estrella, E., Yakhine-Diop, S. M. S., Rodríguez‐Arribas, M., & Fuentes, J. M. (2015) · Current topics in neurotoxicity · doi:10.1007/978-3-319-13939-5_6 · Cited by 1

In silico and In vivo Evaluation of Oxidative Stress Inhibitors Against Parkinson's Disease using the C. elegans Model

Pradeep, H., Ashok, A., Prakash, I., Priya, C. I., Zinzala, J., Marigowda, V. V., & Sosalegowda, A. H. (2020) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207323666200514074128 · Cited by 1

Basic Leucine Zipper Protein Nuclear Factor Erythroid 2–related Factor 2 as a Potential Therapeutic Target in Brain Related Disorders

Goyal, A., Gopika, S., & Agrawal, N. (2022) · Protein and Peptide Letters · doi:10.2174/0929866529666220622124253 · Cited by 1

Polymorphism of Amyloid Fibrils and their Complexes with Catalase

Milton, N. G. N., & Harris, J. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394431-3.00023-7 · Cited by 1

Sexually Dimorphic Effect of Zonisamide on Behavioral Locomotor Activity in a Rat Model of Parkinson's disease

Moayeri, A., Khalili, Z., & Darvishi, M. (2019) · Research Repository Portal (Ilam University of Medical Sciences) · Cited by 1

Αποτίμηση αντιοξειδωτικής ικανότητας ποικιλίας ελαιολάδου του Αγίου Όρους με συνδυασμό μοριακών τεχνικών

Κούκα, Π. (2020) · doi:10.12681/eadd/47951 · Cited by 1

Efectos de la quercetina sobre las alteraciones en el comportamiento y estrés oxidativo inducidos por rayos X en ratas

Hernández, R. M. (2013) · doi:10.18002/10612/2683

THE PROTECTIVE ROLE OF NRF2/KEAP1 IN NEUROLOGICAL DISEASE AND OXIDATIVE STRESS-INDUCED CELL DAMAGE

Bergström, P. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)

The Potential Targets of Chinese Medicines in the Treatment of Parkinson’s Disease: Old Wine in New Bottles

Zhang, Y., Li, J., Wang, N., Ming, J., Cai, Z., & Li, X. (2016) · Journal of Pharmacy and Pharmacology · doi:10.17265/2328-2150/2016.11.002

Brain-derived oligopeptides show neuroprotective properties in rats with Parkinson-like syndrome

Gorbach, T. V., Наконечна, О. А., Tkachenko, A. S., Bezega, Y., & Молчанова, А. И. (2017) · Medicinski casopis · doi:10.5937/mckg51-15877

Culprit effect of oxidative stress in the development of Parkinson's disease: A conundrum of senescence

Saxena, R., & Rai, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818698-5.00005-5

Capacity of Neurotrophic Factors of the GDNF Family in Supporting the Survival of Dopaminergic Neurons in the Central Nervous System of the Aging Mouse

Goodison, T. (2013) · Griffith Research Online · doi:10.25904/1912/3778

Cardiac and Mitochondrial Impacts of Acute Pulmonary Xenobiotic Exposure

Nichols, C. E. (2016) · doi:10.33915/etd.6313

The Aging Brain

Rajput, R., Kaur, R., Chadha, R., Mani, S., Rachana, R., Kaur, H., & Singh, M. (2022) · IGI Global eBooks · doi:10.4018/978-1-6684-5295-0.ch008

Influence of Age on Sleep Deprivation Induced Oxidative Stress in Different Brain Regions of Young and Old Rats

Raina, N., Chauhan, D. S., & Tripathi, S. (2021) · Scholars Journal of Applied Medical Sciences · doi:10.36347/sjams.2021.v09i12.022

Atenuación de parámetros metabólicos, inflamatorios y de estrés oxidante a lo largo de la vida de ratones obesos GMS

Bautista, R. J. H. (2015) · doi:10.24275/uami.474299231

MICROSCOPIC CHANGES OF THE CEREBRAL CORTEX SENSORIMOTOR AREA UNDER EXPERIMENTAL HYPERHOMOCYSTEINEMIA, HYPER- AND HYPOTHYROIDISM AND THEIR COMBINED INFLUENCE

Nechiporuk, V. M., Pentyuk, L. О., & Korda, M. M. (2022) · Bulletin of Problems Biology and Medicine · doi:10.29254/2077-4214-2022-2-2-165-109-123

Analyses phytochimiques et détermination de l’activité antiarthritique in vitro des extraits de graines de Linum usitatissimum L

Cheurfa, M., Noui, A., Mohammadi, K. K., & Mohammadi, R. (2022) · Phytothérapie · doi:10.3166/phyto-2022-0323

www.mdpi.com/journal/ijms The Role of Free Radicals in the Aging Brain and Parkinson’s Disease: Convergence and Parallelism

Kumar, H., Lim, H.-W., More, E. V., Kim, B.-W., Kim, I. S., & Choi, D.-K. (2012)

Free radicals in Parkinson's disease

Koutsilieri, E., Scheller, C., Grünblatt, E., Keinosuke, N. A. R. A., Li, J., & Riederer, P. F. (2002) · Journal of Neurology · doi:10.1007/s00415-002-1201-7 · Cited by 117

Free Radicals and Parkinson's Disease

Sood, P., Mohan, M., Kaur, G., Rani, L., Kanojia, N., & Thapa, K. (2025) · Apple Academic Press eBooks · doi:10.1201/9781003560579-13

Increased Oxidative Damage and Decreased Antioxidant Function in Aging Human Substantia Nigra Compared to Striatum: Implications for Parkinson’s Disease

Venkateshappa, C., Harish, G., Mythri, R. B., Mahadevan, A., Bharath, M. M. S., & Shankar, S. K. (2011) · Neurochemical Research · doi:10.1007/s11064-011-0619-7 · Cited by 177

Culprit effect of oxidative stress in the development of Parkinson's disease: A conundrum of senescence

Saxena, R., & Rai, G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818698-5.00005-5