Chromatin Dynamics during Nucleotide Excision Repair: Histones on the Move
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It has been a long-standing question how DNA damage repair proceeds in a nuclear environment where DNA is packaged into chromatin. Several decades of analysis combining in vitro and in vivo studies in various model organisms ranging from yeast to human have markedly increased our understanding of the mechanisms underlying chromatin disorganization upon damage detection and re-assembly after repair. Here, we review the methods that have been developed over the years to delineate chromatin alterations in response to DNA damage by focusing on the well-characterized Nucleotide Excision Repair (NER) pathway. We also highlight how these methods have provided key mechanistic insight into histone dynamics coupled to repair in mammals, raising new issues about the maintenance of chromatin integrity. In particular, we discuss how NER factors and central players in chromatin dynamics such as histone modifiers, nucleosome remodeling factors, and histone chaperones function to mobilize histones during repair.
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The first step both for GG-NER and TC-NER is chromatin remodeling, which allows NER proteins access to sites of damage.
“The first step both for GG-NER and TC-NER is the chromatin remodeling process, which allows a multitude NER proteins access to the sites of damage [93,94].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [94]
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Alhegaili, A. S. (2016) · Figshare
Hamed, H. A. (2018) · ORCA Online Research @Cardiff (Cardiff University)
Ultraviolet-induced DNA damage and repair in mammals
Chauhan, S., Singh, A., Lal, R., Kannaujiya, V. K., & Maurya, G. K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-42857-9.00021-9
- Authors
- Adam, S., & Polo, S. E.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Polo, Sophie E.
- ORCID
- Polo, Sophie E.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2012-09-19
- Volume
- 13
- Issue
- 9
- Pages
- 11895-11911
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC3472782
- OpenAlex
- W2097207953
- Cited by
- 26
- References
- 79
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 2
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- nucleotide excision repair, chromatin dynamics, histone dynamics, DNA repair, histone modifiers, nucleosome remodeling, histone chaperone, chromatin integrity, DNA damage detection
- MeSH terms
- Animals, Chromatin, DNA Damage, DNA Repair, Histones, Humans, Chromatin Assembly and Disassembly
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