The DOI matches its Crossref record; 171 of the 171 references it cites were found in a registry or an index.
Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications
Open accessAbstract
Cell to cell communication is essential for the coordination and proper organization of different cell types in multicellular systems. Cells exchange information through a multitude of mechanisms such as secreted growth factors and chemokines, small molecules (peptides, ions, bioactive lipids and nucleotides), cell-cell contact and the secretion of extracellular matrix components. Over the last few years, however, a considerable amount of experimental evidence has demonstrated the occurrence of a sophisticated method of cell communication based on the release of specialized membranous nano-sized vesicles termed exosomes. Exosome biogenesis involves the endosomal compartment, the multivesicular bodies (MVB), which contain internal vesicles packed with an extraordinary set of molecules including enzymes, cytokines, nucleic acids and different bioactive compounds. In response to stimuli, MVB fuse with the plasma membrane and vesicles are released in the extracellular space where they can interact with neighboring cells and directly induce a signaling pathway or affect the cellular phenotype through the transfer of new receptors or even genetic material. This review will focus on exosomes as intercellular signaling organelles involved in a number of physiological as well as pathological processes and their potential use in clinical diagnostics and therapeutics.
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4 retracted
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Cited by
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
Mashouri, L., Yousefi, H., Aref, A. R., Ahadi, A. M., Molaei, F., & Alahari, S. K. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,363
Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes
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MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
He, X., Dong, Z., Cao, Y., Wang, H., Liu, S., Liao, L., Jin, Y., Yuan, L., & Li, B. (2019) · Stem Cells International · doi:10.1155/2019/7132708 · Cited by 404
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Self-citation
Metadata
- Authors
- Corrado, C., Raimondo, S., Chiesi, A., Ciccia, F., De Leo, G., & Alessandro, R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-03-06
- Volume
- 14
- Issue
- 3
- Pages
- 5338-5366
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2139623099
- Cited by
- 396
- References
- 171
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Corrado, C., Raimondo, S., Chiesi, A., Ciccia, F., De Leo, G., & Alessandro, R. (2013). Exosomes as Intercellular Signaling Organelles Involved in Health and Disease: Basic Science and Clinical Applications. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms14035338
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