The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders
Open accessAbstract
The Trk family of receptors play a wide variety of roles in physiological and disease processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in particular has attracted major attention due to its critical role in signalling for brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4 (NT4). TrkB signalling is indispensable for the survival, development and synaptic plasticity of several subtypes of neurons in the nervous system. Substantial evidence has emerged over the last decade about the involvement of aberrant TrkB signalling and its compromise in various neuropsychiatric and degenerative conditions. Unusual changes in TrkB signalling pathway have also been observed and implicated in a range of cancers. Variations in TrkB pathway have been observed in obesity and hyperphagia related disorders as well. Both BDNF and TrkB have been shown to play critical roles in the survival of retinal ganglion cells in the retina. The ability to specifically modulate TrkB signalling can be critical in various pathological scenarios associated with this pathway. In this review, we discuss the mechanisms underlying TrkB signalling, disease implications and explore plausible ameliorative or preventive approaches.
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Citations
Cites
1 retracted
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“TrkB activation regulates synaptic plasticity by promoting the phospholipase Cγ (PLCγ) mediated pathways through downstream protein kinase C signalling [12].”
BackgroundNeurotrophin-regulated signalling pathways
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“The tyrosine phosphorylation is triggered by the binding of neurotrophins leading to recruitment of pleckstrin homology (PH) and SH2 domain containing proteins such as FRS2, Shc, SH2B and SH2B2 that regulate distinct overlapping signalling cascades [8,9].”
BackgroundThe Trk family of neurotrophin receptors
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Cited by
El Hayek, L., Khalifeh, M., Zibara, V., Abi Assaad, R., Emmanuel, N., Karnib, N., El-Ghandour, R., Nasrallah, P., Bilen, M., Ibrahim, P., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1661-18.2019 · Cited by 539
Venkatesan, R., Ji, E., & Kim, S. Y. (2015) · BioMed Research International · doi:10.1155/2015/814068 · Cited by 212
BDNF signaling during the lifetime of dendritic spines
Zagrebelsky, M., Tacke, C., & Korte, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03226-5 · Cited by 147
Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists
Boltaev, U., Meyer, Y., Tolibzoda, F., Jacques, T., Gassaway, M., Xu, Q., Wagner, F., Zhang, Y.-L., Palmer, M., Holson, E., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aal1670 · Cited by 94
Zhao, Y., Zhang, Z., Qin, S., Fan, W., Li, W., Liu, J., Wang, S., Xu, Z., & Zhao, M. (2021) · Neural Plasticity · doi:10.1155/2021/9926445 · Cited by 68
Metadata
- Authors
- Gupta, V., You, Y., Gupta, V., Klistorner, A., & Graham, S.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2013-05-13
- Volume
- 14
- Issue
- 5
- Pages
- 10122-10142
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W1995290481
- Cited by
- 258
- References
- 148
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gupta, V., You, Y., Gupta, V., Klistorner, A., & Graham, S. (2013). TrkB Receptor Signalling: Implications in Neurodegenerative, Psychiatric and Proliferative Disorders. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms140510122
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
