The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Adenosine Receptors: Expression, Function and Regulation
Open accessAbstract
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which mediate the physiological actions of adenosine. To date, four AR subtypes have been cloned and identified in different tissues. These receptors have distinct localization, signal transduction pathways and different means of regulation upon exposure to agonists. This review will describe the biochemical characteristics and signaling cascade associated with each receptor and provide insight into how these receptors are regulated in response to agonists. A key property of some of these receptors is their ability to serve as sensors of cellular oxidative stress, which is transmitted by transcription factors, such as nuclear factor (NF)-κB, to regulate the expression of ARs. Recent observations of oligomerization of these receptors into homo- and heterodimers will be discussed. In addition, the importance of these receptors in the regulation of normal and pathological processes such as sleep, the development of cancers and in protection against hearing loss will be examined.
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Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355
Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18
Herrera-Campos, A. B., Zamudio-Martinez, E., Delgado-Bellido, D., Fernández-Cortés, M., Montuenga, L. M., Oliver, F. J., & Garcia-Diaz, A. (2022) · Cancers · doi:10.3390/cancers14112740 · Cited by 17
Metadata
- Authors
- Sheth, S., Brito, R., Mukherjea, D., Rybak, L., & Ramkumar, V.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2014-01-28
- Volume
- 15
- Issue
- 2
- Pages
- 2024-2052
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2095596429
- Cited by
- 401
- References
- 155
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sheth, S., Brito, R., Mukherjea, D., Rybak, L., & Ramkumar, V. (2014). Adenosine Receptors: Expression, Function and Regulation. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms15022024
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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