The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Open accessAbstract
Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of behavior is unknown. Since one outcome of SNARE-dependent gliotransmission is the regulation of extracellular adenosine and because adenosine promotes sleep, we genetically inhibited the release of gliotransmitters and asked if astrocytes play an unsuspected role in sleep regulation. Inhibiting gliotransmission attenuated the accumulation of sleep pressure, assessed by measuring the slow wave activity of the EEG during NREM sleep and prevented cognitive deficits associated with sleep loss. Since the sleep-suppressing effects of the A1 receptor antagonist CPT were prevented following inhibition of gliotransmission and because intracerebroventricular delivery of CPT to wildtype mice mimicked the transgenic phenotype we conclude that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors.
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Cites
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Self-citationAdenosine: A Mediator of the Sleep-Inducing Effects of Prolonged Wakefulness
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Cited by
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
Tripartite synapses: astrocytes process and control synaptic information
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Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
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Control of sleep and wakefulness
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Metadata
- Authors
- Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T., Haydon, P. G., & Frank, M. G.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 61
- Issue
- 2
- Pages
- 213-219
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2120144854
- Cited by
- 874
- References
- 28
- FWCI
- 31.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Halassa, M. M., Florian, C., Fellin, T., Munoz, J. R., Lee, S.-Y., Abel, T., Haydon, P. G., & Frank, M. G. (2009). Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss. Neuron. https://doi.org/10.1016/j.neuron.2008.11.024
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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