The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Lipid Metabolism, Apoptosis and Cancer Therapy
Open accessAbstract
Lipid metabolism is regulated by multiple signaling pathways, and generates a variety of bioactive lipid molecules. These bioactive lipid molecules known as signaling molecules, such as fatty acid, eicosanoids, diacylglycerol, phosphatidic acid, lysophophatidic acid, ceramide, sphingosine, sphingosine-1-phosphate, phosphatidylinositol-3 phosphate, and cholesterol, are involved in the activation or regulation of different signaling pathways. Lipid metabolism participates in the regulation of many cellular processes such as cell growth, proliferation, differentiation, survival, apoptosis, inflammation, motility, membrane homeostasis, chemotherapy response, and drug resistance. Bioactive lipid molecules promote apoptosis via the intrinsic pathway by modulating mitochondrial membrane permeability and activating different enzymes including caspases. In this review, we discuss recent data in the fields of lipid metabolism, lipid-mediated apoptosis, and cancer therapy. In conclusion, understanding the underlying molecular mechanism of lipid metabolism and the function of different lipid molecules could provide the basis for cancer cell death rationale, discover novel and potential targets, and develop new anticancer drugs for cancer therapy.
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Cites
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Cited by
Mondul, A. M., Moore, S. C., Weinstein, S. J., Karoly, E. D., Sampson, J. N., & Albanes, D. (2015) · International Journal of Cancer · doi:10.1002/ijc.29576 · Cited by 179
Jabalera, Y., Sola-Leyva, A., Peigneux, A., Vurro, F., Iglesias, G. R., Vilchez-Garcia, J., Pérez-Prieto, I., Aguilar-Troyano, F. J., López-Cara, L. C., Carrasco-Jiménez, M. P., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11080408 · Cited by 27
Dehghani, M., Samani, Z., Abidi, H., Manzouri, L., Mahmoudi, R., Hosseini Teshnizi, S., & Nikseresht, M. (2018) · International Journal of Genomics · doi:10.1155/2018/4863757 · Cited by 9
Metadata
- Authors
- Huang, C., & Freter, C.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-01-02
- Volume
- 16
- Issue
- 1
- Pages
- 924-949
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W1996221314
- Cited by
- 444
- References
- 169
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
