The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health
Open accessAbstract
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is considered to be an independent risk factor for cardio and cerebrovascular diseases. However, it is still not clear if Hcy is a marker or a causative agent of diseases. More and more research data suggest that Hcy is an important indicator for overall health status. This review represents the current understanding of molecular mechanism of Hcy metabolism and its link to hyperhomocysteinemia-related pathologies in humans. The aberrant Hcy metabolism could lead to the redox imbalance and oxidative stress resulting in elevated protein, nucleic acid and carbohydrate oxidation and lipoperoxidation, products known to be involved in cytotoxicity. Additionally, we examine the role of Hcy in thiolation of proteins, which results in their molecular and functional modifications. We also highlight the relationship between the imbalance in Hcy metabolism and pathogenesis of diseases, such as cardiovascular diseases, neurological and psychiatric disorders, chronic kidney disease, bone tissue damages, gastrointestinal disorders, cancer, and congenital defects.
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Cited by
Homocysteine lowering interventions for preventing cardiovascular events
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Application of Metabolomics in Alzheimer’s Disease
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Hogervorst, J. G. F., Madhloum, N., Saenen, N. D., Janssen, B. G., Penders, J., Vanpoucke, C., De Vivo, I., Vrijens, K., & Nawrot, T. S. (2019) · Environmental Research · doi:10.1016/j.envres.2018.08.032 · Cited by 16
Metadata
- Authors
- Škovierová, H., Vidomanová, E., Mahmood, S., Sopková, J., Drgová, A., Červeňová, T., Halašová, E., & Lehotský, J.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-10-20
- Volume
- 17
- Issue
- 10
- Pages
- 1733
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2533367308
- Cited by
- 422
- References
- 104
- FWCI
- 30.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Škovierová, H., Vidomanová, E., Mahmood, S., Sopková, J., Drgová, A., Červeňová, T., Halašová, E., & Lehotský, J. (2016). The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms17101733
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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