The DOI matches its Crossref record; 205 of the 206 references it cites were found in a registry or an index.
Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics
Open accessAbstract
Melatonin has been speculated to be mainly synthesized by mitochondria. This speculation is supported by the recent discovery that aralkylamine N-acetyltransferase/serotonin N-acetyltransferase (AANAT/SNAT) is localized in mitochondria of oocytes and the isolated mitochondria generate melatonin. We have also speculated that melatonin is a mitochondria-targeted antioxidant. It accumulates in mitochondria with high concentration against a concentration gradient. This is probably achieved by an active transportation via mitochondrial melatonin transporter(s). Melatonin protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting the mitochondrial permeability transition pore (MPTP), and activating uncoupling proteins (UCPs). Thus, melatonin maintains the optimal mitochondrial membrane potential and preserves mitochondrial functions. In addition, mitochondrial biogenesis and dynamics is also regulated by melatonin. In most cases, melatonin reduces mitochondrial fission and elevates their fusion. Mitochondrial dynamics exhibit an oscillatory pattern which matches the melatonin circadian secretory rhythm in pinealeocytes and probably in other cells. Recently, melatonin has been found to promote mitophagy and improve homeostasis of mitochondria.
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“Recently obtained results indicate that mitochondria play an important role in the production, metabolism, and activity of melatonin (Tan et al. 2016; Tan and Reiter 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Tan et al. 2016
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Items 201–205 of 205
Perepechaeva, M. L., Stefanova, N. A., & Grishanova, A. Y. (2014) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-014-2582-1 · Cited by 12
Ultra structural Study of the Human Pineal Gland in Aged Patients Including a Centenarian
Hasegawa, A., Ohtsubo, K., Lzumiyama, N., & Shimada, H. (1990) · Acta Pathologica Japonica · doi:10.1111/j.1440-1827.1990.tb01526.x · Cited by 11
A Light and Electron Microscopic Study of the Pineal Body of the Nutria (Myocastor Coypus)
Salisbury, R. L., Krieg, R. J., & Seibel, H. R. (1981) · Cells Tissues Organs · doi:10.1159/000145376 · Cited by 9
Ni, H., Sun, Q., Tian, T., Feng, X., & Sun, B. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.012 · Cited by 9
ASTROCYTES IN THE PINEAL GLAND OF RAT
Papasozomenos, S. C. (1986) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198603000-00010 · Cited by 4
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas
Reiter, R. J., Rosales-Corral, S., Tan, D. X., Jou, M. J., Galano, A., & Xu, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2609-7 · Cited by 558
Self-citationParadies, G., Paradies, V., Ruggiero, F. M., & Petrosillo, G. (2019) · Cells · doi:10.3390/cells8070728 · Cited by 543
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis
Reiter, R. J., Rosales‐Corral, S., Tan, D., Acuña-Castroviejo, D., Qin, L., Yang, S., & Xu, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040843 · Cited by 453
Self-citationMitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., & Xu, B. (2018) · Molecules · doi:10.3390/molecules23020509 · Cited by 393
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Metadata
- Authors
- Tan, D.-X., Manchester, L., Qin, L., & Reiter, R.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Tan, Dun-Xian
- Reiter, Russel
- ORCID
- Reiter, Russel
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2016-12-16
- Volume
- 17
- Issue
- 12
- Pages
- 2124
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5187924
- OpenAlex
- W2563008150
- Cited by
- 402
- References
- 206
- Citations by year
- 2026: 23 · 2025: 38 · 2024: 51 · 2023: 51 · 2022: 46 · 2021: 50 · 2020: 43 · 2019: 33 · 2018: 33 · 2017: 32
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- melatonin, mitochondrial targeting, mitochondrial protection, mitochondrial dynamics, mitochondrial fission and fusion, mitochondrial biogenesis, mitochondrial permeability transition pore, uncoupling proteins, reactive oxygen species scavenging, mitochondrial membrane potential, mitophagy, acetyltransferase, oocytes, pinealocytes, circadian rhythm
- MeSH terms
- Mitochondrial Uncoupling Proteins, Mitochondrial Permeability Transition Pore, Animals, Antioxidants, Circadian Rhythm, Enzyme Activation, Humans, Melatonin, Mitochondria, Plants, Reactive Oxygen Species, Mitochondrial Membrane Transport Proteins, Membrane Potential, Mitochondrial, Mitochondrial Dynamics, Mitophagy
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