Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378

Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*

REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938

On the origin of mitosing cells

Sagan, L. (1967) · Journal of Theoretical Biology · doi:10.1016/0022-5193(67)90079-3 · Cited by 1,870

Melatonin as an antioxidant: under promises but over delivers

Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,777

Melatonin : a potent, endogenous hydroxyl radical scavenger

Tan, D. (1993) · Endocrine Journal · Cited by 1,659

One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?

Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601

The Haber–Weiss reaction and mechanisms of toxicity

Kehrer, J. P. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00231-6 · Cited by 1,418

Mitochondrial dynamics and apoptosis

Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270

Extrapineal melatonin: sources, regulation, and potential functions

Acuña-Castroviejo, D., Escames, G., Venegas, C., Díaz-Casado, M. E., Lima‐Cabello, E., López, L. C., Rosales‐Corral, S., Tan, D., & Reiter, R. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1579-2 · Cited by 1,133

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

Manchester, L. C., Coto‐Montes, A. M., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J. P., Tan, D. X., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 969

Functions of melatonin in plants: a review

Arnao, M. B., & Hernández‐Ruíz, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12253 · Cited by 905

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

Galano, A., Tan, D. X., & Reiter, R. J. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12010 · Cited by 829

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

Tan, D.-X., Manchester, L., Esteban-Zubero, E., Zhou, Z., & Reiter, R. (2015) · Molecules · doi:10.3390/molecules201018886 · Cited by 719

Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes

Cai, L., Sutter, B. M., Li, B., & Tu, B. P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.004 · Cited by 701

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 680

Melatonin enhances plant growth and abiotic stress tolerance in soybean plants

Wei, W., Li, Q., Chu, Y.-N., Reiter, R. J., Yu, X.-M., Zhu, D.-H., Zhang, W., Ma, B., Lin, Q. F., Zhang, J.-S., et al. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru392 · Cited by 660

Melatonin: Exceeding Expectations

Reiter, R. J., Tan, D. X., & Galano, A. (2014) · Physiology · doi:10.1152/physiol.00011.2014 · Cited by 610

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

Venegas, C., García, J. A. G., Escames, G., Ortiz, F., López, A., Doerrier, C., García‐Corzo, L., López, L. C., Reiter, R. J., & Acuña-Castroviejo, D. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00931.x · Cited by 594

Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes

Tan, D. X., Manchester, L. C., Liu, X., Rosales‐Corral, S., Acuña-Castroviejo, D., & Reiter, R. J. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12026 · Cited by 584

Significance of Melatonin in Antioxidative Defense System: Reactions and Products

Tan, D., Manchester, L. C., Reiter, R. J., Qi, W., Karbownik‐Lewińska, M., & Calvo, J. R. (2000) · Neurosignals · doi:10.1159/000014635 · Cited by 566

Animal and human studies with the mitochondria‐targeted antioxidant MitoQ

Smith, R. A. J., & Murphy, M. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05627.x · Cited by 560

Melatonin mediates the regulation of ABA metabolism, free-radical scavenging, and stomatal behaviour in two Malus species under drought stress

Li, C., Tan, D., Liang, D., Chang, C., Jia, D., & Ma, F. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru476 · Cited by 544

Mitochondrial biogenesis and dynamics in the developing and diseased heart

Dorn, G. W., Vega, R. B., & Kelly, D. P. (2015) · Genes & Development · doi:10.1101/gad.269894.115 · Cited by 470

Mitochondria‐targeted antioxidants

Oyewole, A. O., & Birch‐Machin, M. A. (2015) · The FASEB Journal · doi:10.1096/fj.15-275404 · Cited by 467

Selective targeting of an antioxidant to mitochondria

Smith, R. A. J., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00543.x · Cited by 466

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 457

Hydroxyl Radical and Its Scavengers in Health and Disease

Lipiński, B. (2011) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2011/809696 · Cited by 457

The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances

Hardeland, R., Reiter, R. J., Pöeggeler, B., & Tan, D. X. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80016-8 · Cited by 424

Melatonin, mitochondria, and cellular bioenergetics

Acuña-Castroviejo, D., Martı́n, M., Macías, M. J., Escames, G., León, J., Khaldy, H., & Reiter, R. J. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.300201.x · Cited by 401

Non‐vertebrate melatonin

Hardeland, R., & Pöeggeler, B. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00040.x · Cited by 400

Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice

Elrod, J. W., Wong, R., Mishra, S., Vagnozzi, R. J., Sakthievel, B., Goonasekera, S. A., Karch, J., Gabel, S., Farber, J., Force, T., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43171 · Cited by 384

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

Paradies, G., Petrosillo, G., Paradies, V., Reiter, R. J., & Ruggiero, F. M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00759.x · Cited by 381

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

Jin, H., Kanthasamy, A., Ghosh, A., Anantharam, V., Kalyanaraman, B., & Kanthasamy, A. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.007 · Cited by 373

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 353

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

Arruda, A. P., & Hotamışlıgil, G. S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.010 · Cited by 352

Melatonin but not vitamins C and E maintains glutathione homeostasis in t‐butyl hydroperoxide‐induced mitochondrial oxidative stress

Martı́n, M., Macías, M. J., Escames, G., León, J., & Acuña-Castroviejo, D. (2000) · The FASEB Journal · doi:10.1096/fj.99-0865fje · Cited by 347

A Genome Phylogeny for Mitochondria Among -Proteobacteria and a Predominantly Eubacterial Ancestry of Yeast Nuclear Genes

Esser, C. (2004) · Molecular Biology and Evolution · doi:10.1093/molbev/msh160 · Cited by 324

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Lowes, D. A., Webster, N. R., Murphy, M. P., & Galley, H. F. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aes577 · Cited by 320

Melatonin‐induced increased activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo

Martı́n, M., Macías, M., Escames, G., Reiter, R. J., Agapito, M. T., Ortíz, G. G., & Acuña-Castroviejo, D. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280407.x · Cited by 295

Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae

Weinert, B. T., Iešmantavičius, V., Moustafa, T., Scholz, C. W., Wagner, S., Magnes, C., Zechner, R., & Choudhary, C. (2014) · Molecular Systems Biology · doi:10.1002/msb.134766 · Cited by 283

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

López, A., García, J. A., Escames, G., Venegas, C., Ortiz, F., López, L. C., & Acuña-Castroviejo, D. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00647.x · Cited by 283

On the significance of an alternate pathway of melatonin synthesis via 5‐methoxytryptamine: comparisons across species

Tan, D. X., Hardeland, R., Back, K., Manchester, L. C., Alatorre-Jiménez, M. A., & Reiter, R. J. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12336 · Cited by 282

Melatonin enhances thermotolerance by promoting cellular protein protection in tomato plants

Xu, W., Cai, S., Zhang, Y., Wang, Y., Ahammed, G. J., Xia, X., Shi, K., Zhou, Y., Yu, J., Reiter, R. J., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12359 · Cited by 275

Role of hydrogen peroxide and oxidative stress in healing responses

Rojkind, M., Domı́nguez-Rosales, J. A., Nieto, N., & Greenwel, P. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/pl00012511 · Cited by 268

Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes

Jou, M., Peng, T., Reiter, R. J., Jou, S., WU, H., & Wen, S. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00140.x · Cited by 265

Melatonin as a signal molecule triggering defense responses against pathogen attack in Arabidopsis and tobacco

Lee, H. Y., Byeon, Y., & Back, K. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12165 · Cited by 264

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

Neufeld-Cohen, A., Robles, M. S., Aviram, R., Manella, G., Adamovich, Y., Ladeuix, B., Nir, D., Rousso-Noori, L., Kuperman, Y., Golik, M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519650113 · Cited by 262

Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria

Martı́n, M., Macías, M. J., León, J., Escames, G., Khaldy, H., & Acuña-Castroviejo, D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00138-8 · Cited by 261

Melatonin protects against common deletion of mitochondrial DNA‐augmented mitochondrial oxidative stress and apoptosis

Jou, M., Peng, T.-I., Yu, P., Jou, S., Reiter, R. J., Chen, J., WU, H., Chen, C., & Hsu, L. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00490.x · Cited by 260

Melatonin in Plants – Diversity of Levels and Multiplicity of Functions

Hardeland, R. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00198 · Cited by 256

Mitochondrial dynamics during cell cycling

Horbay, R., & Bilyy, R. O. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1295-5 · Cited by 256

Mitochondria in White, Brown, and Beige Adipocytes

Čedíková, M., Kripnerová, M., Dvořáková, J., Pitule, P., Grundmanova, M., Babuška, V., Müllerová, D., & Kuncová, J. (2016) · Stem Cells International · doi:10.1155/2016/6067349 · Cited by 249

Is multiple sclerosis a mitochondrial disease?

Mao, P., & Reddy, P. H. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.07.002 · Cited by 246

Melatonin-mitochondria Interplay in Health and Disease

Acuña-Castroviejo, D., López, L. C., Escames, G., López, A., García, J. A., & Reiter, R. J. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611794863517 · Cited by 245

Arabidopsis serotonin N ‐acetyltransferase knockout mutant plants exhibit decreased melatonin and salicylic acid levels resulting in susceptibility to an avirulent pathogen

Lee, H. Y., Byeon, Y., Tan, D. X., Reiter, R. J., & Back, K. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12214 · Cited by 243

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT 1‐dependent mechanism during ischemic‐stroke in mice

Yang, Y., Jiang, S., Dong, Y., Fan, C., Zhao, L., Yang, X., Li, J., Di, S., Yue, L., Liang, G., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12193 · Cited by 239

JAK 2/ STAT 3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury

Yang, Y., Duan, W., Jin, Z., Yi, W., Yan, J., Zhang, S., Wang, N., Liang, Z., Li, Y., Chen, W., et al. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12070 · Cited by 232

Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride‐induced liver fibrosis

Kang, J., Hong, J., & Lee, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12319 · Cited by 231

Melatonin stimulates antioxidant enzymes and reduces oxidative stress in experimental traumatic brain injury: the Nrf2–ARE signaling pathway as a potential mechanism

Ding, K., Wang, H., Xu, J., Li, T., Zhang, L., Ding, Y., Zhu, L., He, J., & Zhou, M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.04.031 · Cited by 228

Mitochondria Synthesize Melatonin to Ameliorate Its Function and Improve Mice Oocyte’s Quality under in Vitro Conditions

He, C., Wang, J., Zhang, Z., Yang, M., Li, Y., Tian, X., Ma, T., Tao, J., Zhu, K., Song, Y., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060939 · Cited by 226

The interaction of melatonin and its precursors with aluminium, cadmium, copper, iron, lead, and zinc: An adsorptive voltammetric study

Limson, J. L., Nyokong, T., & Daya, S. (1998) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1998.tb00361.x · Cited by 224

An alcoholic binge causes massive degradation of hepatic mitochondrial DNA in mice

Mansouri, A., Gaou, I., de Kerguenec, C., Amsellem, S., Haouzi, D., Berson, A., Moreau, A., Feldmann, G., Lettéron, P., Pessayre, D., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70566-4 · Cited by 208

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

Galano, A., Medina, M. E., Tan, D. X., & Reiter, R. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12196 · Cited by 204

On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals

Galano, A. (2011) · Physical Chemistry Chemical Physics · doi:10.1039/c0cp02801k · Cited by 197

Melatonin induces browning of inguinal white adipose tissue in Zucker diabetic fatty rats

Jiménez‐Aranda, A., Fernández‐Vázquez, G., Campos, D., Tassi, M., Velasco‐Perez, L., Tan, D. X., Reiter, R. J., & Agil, A. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12089 · Cited by 193

Melatonin counteracts lipopolysaccharide‐induced expression and activity of mitochondrial nitric oxide synthase in rats

Escames, G., León, J., Macías, M. J., Khaldy, H., & Acuña-Castroviejo, D. (2003) · The FASEB Journal · doi:10.1096/fj.02-0692fje · Cited by 191

Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions.

Tan, D.-X., Zheng, X., Kong, J., Manchester, L., Hardeland, R., Kim, S., Xu, X., & Reiter, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150915858 · Cited by 188

Cardiolipin and mitochondrial carriers

Klingenberg, M. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.06.007 · Cited by 187

The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity

Wang, X., Sirianni, A. C., Pei, Z., Cormier, K., Smith, K., Jiang, J., Zhou, S., Wang, H., Zhao, R., Yano, H., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3059-11.2011 · Cited by 186

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

Dragicevic, N., Copes, N., O’Neal-Moffitt, G., Jin, J., Buzzeo, R. W., Mamcarz, M., Tan, J., Cao, C., Olcese, J., Arendash, G. W., et al. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00864.x · Cited by 185

Melatonin‐enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

Chen, J., Wang, L., Wu, C., Hu, Q., Gu, C., Yan, F., Li, J., Yan, W. X., & Chen, G. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12086 · Cited by 183

Melatonin modulates TLR4‐mediated inflammatory genes through MyD88‐ and TRIF‐dependent signaling pathways in lipopolysaccharide‐stimulated RAW264.7 cells

Xia, M., Liang, Y., Wang, H., Chen, X., Huang, Y., Zhang, Z., Chen, Y., Zhang, C., Zhao, M., Xu, D., et al. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01002.x · Cited by 178

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

Quintanilla, R. A., & Johnson, G. V. W. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.07.010 · Cited by 176

Cellular localization and kinetics of the rice melatonin biosynthetic enzymes SNAT and ASMT

Byeon, Y., Lee, H. Y., Lee, K., Park, S.-K., & Back, K. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12103 · Cited by 175

Beneficial effects of melatonin on bovine oocytes maturation: a mechanistic approach

Tian, X., Wang, F., He, C., Zhang, L., Tan, D. X., Reiter, R. J., Xu, J., Ji, P., & Liu, G. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12163 · Cited by 172

Melatonin attenuates traumatic brain injury‐induced inflammation: a possible role for mitophagy

Lin, C., Chao, H., Li, Z., Xu, X., Liu, Y., Hou, L.-J., Liu, N., & Ji, J. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12337 · Cited by 170

Melatonin inhibits apoptosis and improves the developmental potential of vitrified bovine oocytes

Zhao, X., Hao, H., Du, W., Zhao, S., Wang, H., Wang, N., Wang, D., Liu, Y., Qin, T., & Zhu, H. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12290 · Cited by 167

Melatonin, Mitochondrial Homeostasis and Mitochondrial-Related Diseases

Acuña-Castroviejo, D., Escames, G., Carazo, Á., León, J., Khaldy, H., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394344 · Cited by 166

Melatonin immunoreactivity in the photosynthetic prokaryote Rhodospirillum rubrum: implications for an ancient antioxidant system.

Manchester, L. C., Pöeggeler, B., Alvares, F. L., Ogden, G. B., & Reiter, R. J. (1995) · PubMed · Cited by 165

Delivery of pineal melatonin to the brain and SCN: role of canaliculi, cerebrospinal fluid, tanycytes and Virchow–Robin perivascular spaces

Reiter, R. J., Tan, D. X., Kim, S. J., & Cruz, M. H. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0719-7 · Cited by 163

Melatonin in plants and other phototrophs: advances and gaps concerning the diversity of functions

Hardeland, R. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru386 · Cited by 160

Melatonin reduces lipid peroxidation and membrane viscosity

Reiter, R. J., Tan, D., & Galano, A. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00377 · Cited by 154

Role of melatonin in the regulation of autophagy and mitophagy: A review

Coto‐Montes, A. M., Boga, J. A., Rosales‐Corral, S., Fuentes‐Broto, L., Tan, D., & Reiter, R. J. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.04.009 · Cited by 150

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

Escames, G., López, L. C., Ortiz, F., López, A., García, J. A. G., Ros, E., & Acuña-Castroviejo, D. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05755.x · Cited by 147

Protective effects of melatonin and mitochondria-targeted antioxidants against oxidative stress: A review

Ramis, M., Esteban, S., Miralles, A., Tan, D.-X., & Reiter, R. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150619104143 · Cited by 146

Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer

Hevia, D., González‐Menéndez, P., Quirós-González, I., Miar, A., Rodríguez‐García, A., Tan, D. X., Reiter, R. J., Mayo, J. C., & Sainz, R. M. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12210 · Cited by 144

Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells

Jung-Hynes, B. D., Huang, W., Reiter, R. J., & Ahmad, N. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00767.x · Cited by 141

Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium‐dependent translocation of Drp1 to the mitochondria

Xu, S., Pi, H., Zhang, L., Zhang, N.-X., Li, Y., Zhang, H., Tang, J., Li, H., Feng, M., Deng, P., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12310 · Cited by 139

Melatonin‐induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy

Prieto‐Domínguez, N., Ordóñez, R., Fernández, A., Méndez‐Blanco, C., Baulies, A., García‐Ruiz, C., Fernández-Checa, J. C., Mauriz, J. L., & González‐Gallego, J. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12358 · Cited by 139

Circadian Rhythms of Melatonin, Cortisol, and Clock Gene Expression During Simulated Night Shift Work

James, F. O., Cermakian, N., & Boivin, D. B. (2007) · Sleep · doi:10.1093/sleep/30.11.1427 · Cited by 135

Long‐term melatonin administration protects brain mitochondria from aging

Carretero, M., Escames, G., López, L. C., Venegas, C., Dayoub, J. C., García‐Corzo, L., & Acuña-Castroviejo, D. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00700.x · Cited by 135

Melatonin protects against rotenone‐induced oxidative stress in a hemiparkinsonian rat model

Saravanan, K. S., Sindhu, K. M., & Mohanakumar, K. P. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00412.x · Cited by 133

Melatonin controlled apoptosis and protected the testes and sperm quality against bisphenol A-induced oxidative toxicity

Othman, A. I., Edrees, G., El-Missiry, M. A., Ali, D. A., Abouel-Nour, M. F., & Dabdoub, B. R. (2014) · Toxicology and Industrial Health · doi:10.1177/0748233714561286 · Cited by 132

Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation

Su, L., Li, H., Lv, L., Feng, Y., Li, G., Luo, R., Zhou, H., Lei, X., Ma, L., Li, J., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1082020 · Cited by 128

Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart

Akhmedov, A. T., Rybin, V. O., & Marín-García, J. (2014) · Heart Failure Reviews · doi:10.1007/s10741-014-9457-4 · Cited by 128

Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells

Raza, H., John, A., Brown, E. M., Benedict, S., & Kambal, A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.09.002 · Cited by 127

How did life survive Earth's great oxygenation?

Fischer, W. W., Hemp, J., & Valentine, J. S. (2016) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2016.03.013 · Cited by 127

A Circadian Clock Entrained by Melatonin Is Ticking in the Rat Fetal Adrenal

Torres‐Farfan, C., Mendez, N., Abarzúa-Catalán, L., Vilches, N., Valenzuela, G. J., & Serón‐Ferré, M. (2011) · Endocrinology · doi:10.1210/en.2010-1260 · Cited by 125

Glia-Pinealocyte Network: The Paracrine Modulation of Melatonin Synthesis by Tumor Necrosis Factor (TNF)

Cruz‐Machado, S. D. S., Pinato, L., Tamura, E. K., Carvalho‐Sousa, C. E., & Markus, R. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040142 · Cited by 119

Melatonin in Arabidopsis thaliana acts as plant growth regulator at low concentrations and preserves seed viability at high concentrations

Hernández, I. G., Gómez, F. J. V., Cerutti, S. E., Arana, M. V., & Silva, M. F. (2015) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2015.06.011 · Cited by 115

The melatonin metabolite N1‐acetyl‐5‐methoxykynuramine is a potent singlet oxygen scavenger

Schaefer, M., & Hardeland, R. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00614.x · Cited by 114

Melatonin and its brain metabolite N1‐acetyl‐5‐methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice

Tapias, V., Escames, G., López, L. C., López, A., Camacho, E., Carriòn, M. D., Entrena, A., Gallo, M. Á., Espinosa, A., & Acuña-Castroviejo, D. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22123 · Cited by 112

Melatonin production in an aerobic photosynthetic bacterium: An evolutionarily early association with darkness

Tilden, A. R., Becker, M. A., Amma, L. L., Arciniega, J., & McGaw, A. K. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00310.x · Cited by 108

Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis‐associated colon carcinogenesis

Trivedi, P. P., Jena, G., Tikoo, K., & Kumar, V. R. P. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22274 · Cited by 106

A Novel Metabolic Pathway of Melatonin: Oxidation by Cytochromec

Semak, I. V., Naumova, M., Корик, Е. О., Terekhovich, V., Wortsman, J., & Slominski, A. T. (2005) · Biochemistry · doi:10.1021/bi050202d · Cited by 103

The plastid ancestor originated among one of the major cyanobacterial lineages

de Alda, J. A. G. O., Esteban, R., Egaña, M. L. D., & Houmard, J. (2014) · Nature Communications · doi:10.1038/ncomms5937 · Cited by 102

Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas

Muñoz‐Casares, F. C., Ruiz, F. J. P., Briceño, J., Collado, J. A., Muñoz-Castañeda, J. R., Ortega, R., Cruz, A., Túnez, I., Montilla, P., Pera, C., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00291.x · Cited by 102

Predominance of 2‐hydroxymelatonin over melatonin in plants

Byeon, Y., Tan, D. X., Reiter, R. J., & Back, K. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12274 · Cited by 101

Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function

Xu, S., He, M., Zhong, M., Zhang, Y., Wang, Y., Lü, Y., Yang, J., Yu, Z., & Zhou, Z. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00770.x · Cited by 100

Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice

Ding, K., Xu, J., Wang, H., Zhang, L., Wu, Y. G., & Li, T. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.008 · Cited by 99

Scavenging effect of melatonin on hydroxyl radicals generated by alloxan

Brömme, H. J., Mörke, W., Peschke, E., Ebelt, H., & Peschke, D. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-0633.2002.290402.x · Cited by 98

The rat oocyte synthesises melatonin

Sakaguchi, K., Itoh, M., Takahashi, N., Tarumi, W., & Ishizuka, B. (2012) · Reproduction Fertility and Development · doi:10.1071/rd12091 · Cited by 93

2‐Hydroxymelatonin promotes the resistance of rice plant to multiple simultaneous abiotic stresses (combined cold and drought)

Lee, H., & Back, K. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12347 · Cited by 93

Melatonin enhances the occurrence of autophagy induced by oxidative stress in Arabidopsis seedlings

Wang, P., Sun, X., Wang, N., Tan, D. X., & Ma, F. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12233 · Cited by 92

Cyclic-3-hydroxymelatonin (C3HOM), A Potent Antioxidant, Scavenges Free Radicals and Suppresses Oxidative Reactions

Tan, D., Hardeland, R., Manchester, L. C., Galano, A., & Reiter, R. J. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131129113146 · Cited by 92

Protective effect of melatonin‐supported adipose‐derived mesenchymal stem cells against small bowel ischemia‐reperfusion injury in rat

Chang, C., Sung, P., Sun, C., Chen, C., Chiang, H., Huang, T., Chen, Y., Zhen, Y., Chai, H., Chung, S., et al. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12251 · Cited by 91

Molecular cloning and functional analysis of serotonin N‐acetyltransferase from the cyanobacterium Synechocystis sp. PCC 6803

Byeon, Y., Lee, K., Park, Y., Park, S., & Back, K. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12080 · Cited by 91

Horizontal transfer of mitochondria between mammalian cells: beyond co-culture approaches

Berridge, M. V., McConnell, M. J., Grasso, C., Bajzíková, M., Kovářová, J., & Neužil, J. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.04.003 · Cited by 91

Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats

Agil, A., El‐Hammadi, M. M., Jiménez‐Aranda, A., Tassi, M., Abdo, W. S., Fernández‐Vázquez, G., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12241 · Cited by 87

Cell-to-cell movement of mitochondria in plants

Gurdon, C., Sváb, Z., Feng, Y., Kumar, D., & Maliga, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518644113 · Cited by 87

Cultured rat cortical astrocytes synthesize melatonin: absence of a diurnal rhythm

Liu, Y., Zhuang, J., Zhu, H., Shen, Y., Tan, Z., & Zhou, J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00466.x · Cited by 86

Melatonin Signal Transduction Pathways Require E-Box-Mediated Transcription of Per1 and Per2 to Reset the SCN Clock at Dusk

Kandalepas, P. C., Mitchell, J. W., & Gillette, M. U. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157824 · Cited by 85

Protective role of melatonin in mitochondrial dysfunction and related disorders

Paradies, G., Paradies, V., Ruggiero, F. M., & Petrosillo, G. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1475-z · Cited by 84

Protective effect of melatonin against the 1‐methyl‐4‐phenylpyridinium‐induced inhibition of Complex I of the mitochondrial respiratory chain

Absi, E., Ayala, A., Machado, A., & Parrado, J. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.290106.x · Cited by 83

Melatonin prevents adverse myocardial infarction remodeling via Notch1/Mfn2 pathway

Pei, H., Du, J., Song, X., He, L., Zhang, Y., Li, X., Qiu, C., Zhang, Y., Hou, J., Feng, J., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.06.015 · Cited by 82

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of i NOS and preservation of n NOS

Ortiz, F., García, J. A. G., Acuña-Castroviejo, D., Doerrier, C., López, A., Venegas, C., Volt, H., Luna‐Sánchez, M., López, L. C., & Escames, G. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12099 · Cited by 81

N -Acetylserotonin and 6-Hydroxymelatonin against Oxidative Stress: Implications for the Overall Protection Exerted by Melatonin

Álvarez-Diduk, R., Galano, A., Tan, D. X., & Reiter, R. J. (2015) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.5b04920 · Cited by 80

Detection and quantification of melatonin in a dinoflagellate, Gonyaulax polyedra: Solutions to the problem of methoxyindole destruction in non‐vertebrate material

Pöeggeler, B., & Hardeland, R. (1994) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1994.tb00106.x · Cited by 80

Melatonin: A Potential Anti-Oxidant Therapeutic Agent for Mitochondrial Dysfunctions and Related Disorders

Ganie, S. A., Dar, T. A., Bhat, A. H., Dar, K. B., Anees, S., Zargar, M. A., & Masood, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1704 · Cited by 80

Melatonin and Ischemic Stroke: Mechanistic Roles and Action

Andrabi, S. S., Parvez, S., & Tabassum, H. (2015) · Advances in Pharmacological Sciences · doi:10.1155/2015/384750 · Cited by 77

CSF generation by pineal gland results in a robust melatonin circadian rhythm in the third ventricle as an unique light/dark signal

Tan, D., Manchester, L. C., & Reiter, R. J. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.11.018 · Cited by 77

Melatonin prevents cytosolic calcium overload, mitochondrial damage and cell death due to toxically high doses of dexamethasone-induced oxidative stress in human neuroblastoma SH-SY5Y cells

Suwanjang, W., Abramov, A. Y., Charngkaew, K., Govitrapong, P., & Chetsawang, B. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.05.003 · Cited by 77

Melatonin prevents the dynamin‐related protein 1‐dependent mitochondrial fission and oxidative insult in the cortical neurons after 1‐methyl‐4‐phenylpyridinium treatment

Chuang, J., Pan, I., Hsieh, C., Huang, C., Chen, P., & Shin, J.-W. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12343 · Cited by 76

Cyclic 3-Hydroxymelatonin: A Melatonin Metabolite Generated as a Result of Hydroxyl Radical Scavenging

Tan, D., Manchester, L. C., Reiter, R., & Plummer, B. F. (1999) · Neurosignals · doi:10.1159/000014571 · Cited by 75

How to Achieve High-Quality Oocytes? The Key Role of Myo-Inositol and Melatonin

Vitale, S. G., Rossetti, P., Corrado, F., Rapisarda, A. M. C., Vignera, S. L., Condorelli, R. A., Valenti, G., Sapia, F., Laganà, A. S., & Buscema, M. (2016) · International Journal of Endocrinology · doi:10.1155/2016/4987436 · Cited by 75

Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3‐L1 preadipocytes

Kato, H., Tanaka, G., Masuda, S., Ogasawara, J., Sakurai, T., Kizaki, T., Ohno, H., & Izawa, T. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12259 · Cited by 72

Antioxidative protection in a high‐melatonin organism: The dinoflagellate Gonyaulax polyedra is rescued from lethal oxidative stress by strongly elevated, but physiologically possible concentrations of melatonin

Antolı́n, I., Obst, B., Burkhardt, S., & Hardeland, R. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00353.x · Cited by 72

Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin

Galano, A., Tan, D. X., & Reiter, R. J. (2013) · RSC Advances · doi:10.1039/c3ra44604b · Cited by 72

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

Chen, Y., Qing, W., Sun, M., Lv, L., Guo, D., & Jiang, Y. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1067806 · Cited by 71

Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells

Santofimia‐Castaño, P., Ruy, D. C., Garcia-Sanchez, L., Jiménez-Blasco, D., Fernández‐Bermejo, M., Bolaños, J. P., Salido, G. M., & González, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.033 · Cited by 69

Nix: A receptor protein for mitophagy in mammals

Kanki, T. (2010) · Autophagy · doi:10.4161/auto.6.3.11420 · Cited by 69

Molecular Basis for Defining the Pineal Gland and Pinealocytes as Targets for Tumor Necrosis Factor

Carvalho‐Sousa, C. E., Cruz‐Machado, S. D. S., Tamura, E. K., Fernandes, P. A. C. M., Pinato, L., Muxel, S. M., Cecon, E., & Markus, R. P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00010 · Cited by 68

Melatonin restores the mitochondrial production of ATP in septic mice.

López, L. C., Escames, G., Ortiz, F., Ros, E., & Acuña-Castroviejo, D. (2006) · PubMed · Cited by 67

Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signalling

Ahmed, K. A., Sawa, T., Ihara, H., Kasamatsu, S., Yoshitake, J., Rahaman, M. M., Okamoto, T., Fujii, S., & Akaike, T. (2011) · Biochemical Journal · doi:10.1042/bj20111130 · Cited by 67

Characterization of the Saccharomyces cerevisiae Homolog of the Melatonin Rhythm Enzyme Arylalkylamine N-Acetyltransferase (EC 2.3.1.87)

Ganguly, S., Mummaneni, P., Steinbach, P. J., Klein, D. C., & Coon, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107222200 · Cited by 65

Liposomal melatonin rescues methamphetamine‐elicited mitochondrial burdens, pro‐apoptosis, and dopaminergic degeneration through the inhibition PKCδ gene

Nguyen, X.-K. T., Lee, J., Shin, E., Dang, D., Jeong, J. H., Nguyen, T. L., Nam, Y., Cho, H., Lee, J., Park, D. H., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12195 · Cited by 65

Melatonin and structurally similar compounds have differing effects on inflammation and mitochondrial function in endothelial cells under conditions mimicking sepsis

Lowes, D. A., Almawash, A., Webster, N. R., Reid, V. L., & Galley, H. F. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer149 · Cited by 65

Melatonin improves mitochondrial function in inguinal white adipose tissue of Zücker diabetic fatty rats

Jiménez‐Aranda, A., Fernández‐Vázquez, G., A‐Serrano, M. M., Reiter, R. J., & Agil, A. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12147 · Cited by 64

Daily differential expression of melatonin‐related genes and clock genes in rat cumulus–oocyte complex: changes after pinealectomy

Coelho, L. D. A., Peres, R. S., do Amaral, F. G., Reiter, R. J., & Cipolla‐Neto, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12234 · Cited by 64

Mitochondrial Transfer from Astrocytes to Neurons following Ischemic Insult: Guilt by Association?

Berridge, M. V., Schneider, R. T., & McConnell, M. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.023 · Cited by 63

Mitochondrial and Metabolic Dysfunction in Renal Convoluted Tubules of Obese Mice: Protective Role of Melatonin

Stacchiotti, A., Favero, G., Giugno, L., Lavazza, A., Reiter, R. J., Rodella, L. F., & Rezzani, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111141 · Cited by 62

Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury

Zhang, H., Liu, D., Wang, X., Chen, X., Long, Y., Chai, W., Zhou, X. Q., Xi, R., Zhang, Q., Wang, H., et al. (2012) · Journal of Pineal Research · doi:10.1111/jpi.12033 · Cited by 62

Melatonin treatment improves primary progressive multiple sclerosis: a case report

González, A. L., Álvarez‐Sánchez, N., Lardone, P. J., Cruz‐Chamorro, I., Martínez‐López, A., Guerrero, J. M., Reiter, R. J., & Carrillo‐Vico, A. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12203 · Cited by 62

Decline in cytochrome c oxidase activity in rat-brain mitochondria with aging. Role of peroxidized cardiolipin and beneficial effect of melatonin

Petrosillo, G., Benedictis, V. D., Ruggiero, F. M., & Paradies, G. (2013) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-013-9505-0 · Cited by 60

Melatonin protects against chronic intermittent hypoxia-induced cardiac hypertrophy by modulating autophagy through the 5′ adenosine monophosphate-activated protein kinase pathway

Xie, S., Deng, Y., Pan, Y., Wang, Z., Ren, J., Guo, X., Yuan, X., Shang, J., & Liu, H. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.149 · Cited by 59

Melatonin attenuates methamphetamine‐induced disturbances in mitochondrial dynamics and degeneration in neuroblastoma SH ‐ SY 5 Y cells

Parameyong, A., Charngkaew, K., Govitrapong, P., & Chetsawang, B. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12078 · Cited by 59

Chloroplast-encoded serotonin N-acetyltransferase in the red alga Pyropia yezoensis: gene transition to the nucleus from chloroplasts

Byeon, Y., Lee, H. Y., Choi, D., & Back, K. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru357 · Cited by 59

Melatonin reduces endoplasmic reticulum stress and autophagy in liver of leptin‐deficient mice

de Luxán‐Delgado, B., Potes, Y., Rubio‐González, A., Caballero, B., Solano, J. J., Fernández, M. F., Bermúdez, M., Guimarães, M. R. M., Vega‐Naredo, I., Boga, J. A., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12333 · Cited by 59

Exogenous melatonin enhances bile flow and ATP levels after cold storage and reperfusion in rat liver: implications for liver transplantation

Vairetti, M., Ferrigno, A., Bertone, R., Rizzo, V., Richelmi, P., Bertè, F., Reiter, R. J., & Freitas, I. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00193.x · Cited by 55

Mechanism of neuroprotection of melatonin against beta-amyloid neurotoxicity

Йонов, М., Burchell, V., Klajnert‐Maculewicz, B., Bryszewska, M. J., & Abramov, A. Y. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.045 · Cited by 55

The effect of melatonin on antioxidant enzymes in human diabetic skin fibroblasts.

Kilańczyk, E., & Bryszewska, M. J. (2003) · PubMed · Cited by 52

Reactive Oxygen Species in the Cerebral Circulation: Are They All Bad?

Miller, A. A., Drummond, G. R., & Sobey, C. G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1113 · Cited by 51

Effect and possible mechanisms of melatonin treatment on the quality and developmental potential of aged bovine oocytes

Liang, S., Guo, J., Choi, J., Kim, N., & Cui, X. (2016) · Reproduction Fertility and Development · doi:10.1071/rd16223 · Cited by 50

Melatonin attenuates the mitochondrial translocation of mitochondrial fission proteins and Bax, cytosolic calcium overload and cell death in methamphetamine-induced toxicity in neuroblastoma SH-SY5Y cells

Parameyong, A., Govitrapong, P., & Chetsawang, B. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.07.004 · Cited by 48

Cardiac disease due to random mitochondrial DNA mutations is prevented by cyclosporin A

Mott, J. L., Zhang, D., Freeman, J. C., Mikolajczak, P. C., Chang, S.-J., & Zassenhaus, H. P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.104 · Cited by 48

Quantitation of ultrastructural changes in the mouse pineal in response to continuous illumination

Upson, R. H., Benson, B., & Satterfield, V. (1976) · The Anatomical Record · doi:10.1002/ar.1091840306 · Cited by 48

Melatonin protects lung mitochondria from aging

Acuña-Castroviejo, D., Carretero, M., Doerrier, C., López, L. C., García‐Corzo, L., Tresguerres, J. A. F., & Escames, G. (2011) · AGE · doi:10.1007/s11357-011-9267-8 · Cited by 46

Melatonin enhances thein vitromaturation and developmental potential of bovine oocytes denuded of the cumulus oophorus

Zhao, X., Jiang-tao, M. I. N., Du, W., Hao, H., Liu, Y., Qin, T., Wang, D., & Zhu, H. (2014) · Zygote · doi:10.1017/s0967199414000161 · Cited by 46

Dynamic comparisons of high-resolution expression profiles highlighting mitochondria-related genes between in vivo and in vitro fertilized early mouse embryos

Ren, L., Wang, Z., An, L., Zhang, Z., Tan, K., Miao, K., Tao, L., Cheng, L., Zhang, Z., Yang, M., et al. (2015) · Human Reproduction · doi:10.1093/humrep/dev228 · Cited by 42

Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria

Waseem, M., Tabassum, H., & Parvez, S. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.08.005 · Cited by 42

Ultrastructure of the pineal gland in the adult rat.

Calvo, J., & Boya, J. (1984) · PubMed · Cited by 41

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line

Luchetti, F., Canonico, B., Mannello, F., Masoni, C., D'Emilio, A., Battistelli, M., Papa, S., & Falcieri, E. (2006) · Toxicology in Vitro · doi:10.1016/j.tiv.2006.08.003 · Cited by 40

Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity

Uzhachenko, R. V., Shanker, A., Yarbrough, W. G., & Ivanova, A. V. (2015) · Oncotarget · doi:10.18632/oncotarget.4537 · Cited by 39

Obesity and Oxidative Stress: Potential Roles of Melatonin as Antioxidant and Metabolic Regulator

Bonnefont‐Rousselot, D. (2014) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530314666140604151452 · Cited by 38

Role of hydroxyl radical formation in neurotoxicity as revealed by in vivo free radical trapping

Obata, T. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(02)00076-0 · Cited by 38

Chloroplastic and cytoplasmic overexpression of sheep serotonin N‐acetyltransferase in transgenic rice plants is associated with low melatonin production despite high enzyme activity

Byeon, Y., Lee, H. Y., & Back, K. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12231 · Cited by 36

Effects of the Calcineurin Dependent Signaling Pathway Inhibition by Cyclosporin a on Early and Late Cardiac Remodeling Following Myocardial Infarction

Youn, T., Piao, H., Kwon, J., Choi, S., Kim, H., Park, D.-G., Kim, D. W., Kim, Y., & Cho, M. C. (2002) · European Journal of Heart Failure · doi:10.1016/s1388-9842(02)00120-4 · Cited by 32

Melatonin attenuated adipogenesis through reduction of the CCAAT/enhancer binding protein beta by regulating the glycogen synthase 3 beta in human mesenchymal stem cells

Rhee, Y., & Ahn, J. (2016) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0463-3 · Cited by 31

Cytochemical investigation of acetyl-serotonin-transferase activity in the pineal gland.

Kerényi, N. A., Balogh, I., Somogyi, E., & Sótonyi, P. (1979) · PubMed · Cited by 30

Melatonin Ameliorates Arsenite-Induced Neurotoxicity: Involvement of Autophagy and Mitochondria

Teng, Y. C., Tai, Y. I., Huang, H. J., & Lin, A. M. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9250-y · Cited by 28

Modulation of Pineal Melatonin Synthesis by Glutamate Involves Paracrine Interactions between Pinealocytes and Astrocytes through NF- κ B Activation

Villela, D., Atherino, V. F., Lima, L. D. S., Moutinho, A. A., do Amaral, F. G., Peres, R., de Lima, T. M., Torrão, A. D. S., Cipolla‐Neto, J., Scavone, C., et al. (2013) · BioMed Research International · doi:10.1155/2013/618432 · Cited by 28

Protective Effect of Melatonin on Methamphetamine-Induced Apoptosis in Glioma Cell Line

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Mitochondria in human pluripotent stem cell apoptosis

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