Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082

Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

Smirnova, E., Griparić, L., Shurland, D., & van der Bliek, A. M. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2245 · Cited by 1,938

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

Gomes, L. C., Benedetto, G. D., & Scorrano, L. (2011) · Nature Cell Biology · doi:10.1038/ncb2220 · Cited by 1,735

Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 1×

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

Rambold, A. S., Kostelecky, B., Elia, N., & Lippincott‐Schwartz, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107402108 · Cited by 1,188

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., & Mihara, K. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007152 · Cited by 1,110 · cited 1×

Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

Cribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,061

Endoplasmic reticulum-mitochondria contacts: Function of the junction

Rowland, A. A., & Voeltz, G. K. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3440 · Cited by 1,018 · cited 1×

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

Wang, Z., Jiang, H., Chen, S., Du, F., & Wang, X. (2012) · Cell · doi:10.1016/j.cell.2011.11.030 · Cited by 949

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

Mańczak, M., Calkins, M. J., & Reddy, P. H. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr139 · Cited by 847

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

Matsunaga, Y., Qadota, H., Ghazal, N., Lesanpezeshki, L., Dorendorf, T., Moody, J. C., Ahier, A., Matheny, C. J., Vanapalli, S. A., Zuryn, S., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07042-3 · Cited by 6

Forsythia suspensa Leaves Triterpenoids Induce Breast Cancer Cell Apoptosis via the Mitochondrial Pathway

Li, X., Wang, X., Chen, L., Ning, E., Fan, H., Liang, J., Lai, X., Zhang, L., Gao, Y., Li, Y., et al. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70664 · Cited by 7

Regulation mechanism of GPS2 on PGC-1α/Drp1-mediated mitochondrial dynamics in inflammation of acute lung injury

Zhao, L., Gu, C., Zhang, Y., Yan, J., Qiu, L., Qin, X., & Wang, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112838 · Cited by 7

AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis

Cheng, L., Zhu, M., Xu, X. M., Li, X., Yao, Y.-M., Liu, C., & He, K. (2024) · iScience · doi:10.1016/j.isci.2024.111005 · Cited by 7

Mitochondrial Dysfunction-Molecular Mechanisms and Potential Treatment approaches of Hepatocellular Carcinoma

Zeng, L., Zhu, L., Fu, S., Li, Y., & Hu, K. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05144-4 · Cited by 10

Research progress on ncRNAs regulation of mitochondrial dynamics in diabetes

Wu, Y., Lan, H., Zhang, D., Hu, Z., Zhang, J., Li, Z., Xia, P., Tang, X., Cai, X., & Yu, P. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30878 · Cited by 7

Post-Translational Modification of Drp1 is a Promising Target for Treating Cardiovascular Diseases

Ji, Y., Zhou, H., Chen, Y., & Li, J. (2023) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2023.0043 · Cited by 8

Glial lipid droplets resolve ROS during sleep

Goodman, L. D., Moulton, M. J., & Bellen, H. J. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01546-7 · Cited by 7

Reprogramming mitochondrial homeostasis in renal ischemia–reperfusion injury

Wang, K., Wang, H., Zhang, Y., Zhang, Z., Wang, L., Yang, J., Man, J., & Yang, L. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112294 · Cited by 6

Structural and mitochondrial dendritic degenerations in old hypoglossal motor neurons

Christensen, T. A., & Fogarty, M. J. (2026) · GeroScience · doi:10.1007/s11357-025-02075-w · Cited by 6

Molecular Mechanisms of Chondrocyte Hypertrophy Mediated by Physical Cues and Therapeutic Strategies in Osteoarthritis

Jin, G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020624 · Cited by 6

How calcineurin inhibitors affect cognition

Thiankhaw, K., Chattipakorn, N., & Chattipakorn, S. C. (2024) · Acta Physiologica · doi:10.1111/apha.14161 · Cited by 6

Ethnicity‐related differences in mitochondrial regulation by insulin stimulation in diabetes

Neikirk, K., Kabugi, K., Mungai, M., Kula, B., Smith, N., & Hinton, A. O., Jr. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31317 · Cited by 7

Mitigating the Functional Deficit after Neurotoxic Motoneuronal Loss by an Inhibitor of Mitochondrial Fission

Ciuro, M., Sangiorgio, M., Cacciato, V., Cantone, G., Fichera, C., Salvatorelli, L., Magro, G. G., Leanza, G., Vecchio, M. M., Valle, M. S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137059 · Cited by 6

Cellular and Molecular Processes in Pulmonary Hypertension

Maietta, V., Reyes-García, J., Yadav, V., Zheng, Y., Peng, X., & Wang, Y.-X. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-68748-9_2 · Cited by 6

Rapamycin encourages the maintenance of mitochondrial dynamic balance and mitophagy activity for improving developmental competence of blastocysts in porcine embryos in vitro

Park, H., Heo, G., Yang, S., & Koo, D. (2023) · Molecular Reproduction and Development · doi:10.1002/mrd.23681 · Cited by 6

SOHO State of the Art Updates and Next Questions: Understanding and Overcoming Venetoclax Resistance in Hematologic Malignancies

Forsberg, M., & Konopleva, M. Y. (2023) · Clinical Lymphoma Myeloma & Leukemia · doi:10.1016/j.clml.2023.10.006 · Cited by 6

Aging: An evolutionary competition between host cells and mitochondria

Tan, D. X. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.04.007 · Cited by 6

PARIS–DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy

Mukherjee, D., Chander, V., & Bandyopadhyay, A. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00106-20 · Cited by 6

Molecular mechanisms of ferroptosis in ulcerative colitis: insights from machine learning, WGCNA, and immune cell infiltration analysis

Zhai, L., Pan, H., Guo, Z., Zhou, W., Ding, Q., Wang, H., Chen, Q., & Yao, P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1615186 · Cited by 5

The Role of Apoptosis and Ferroptosis in Primary Mitochondrial Diseases: Mechanisms and Pathogenesis

Kolotova, A. A., Shestopalov, A., & Kutsev, S. I. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27135931 · Cited by 5

Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

Geum-Lan, H. O. N. G., Kyung-Hyun, K. I. M., Sung-Pil, C. H. O., Hui-Ju, L. E. E., Yae-Ji, K. I. M., & Ju-Young, J. U. N. G. (2024) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(24)60619-9 · Cited by 5

Bifenthrin causes disturbance in mitochondrial dynamics and bioenergetic system in human embryonic kidney cells (HEK 293)

Das, A., Das, M., Paul, N., Chatterjee, S., Sarkar, K., Bank, S., Sarkar, J., Bankura, B., Roy, D., Acharya, K., et al. (2025) · Environmental Pollution · doi:10.1016/j.envpol.2025.125707 · Cited by 5

Unleashing the cardioprotective potential of berberine against doxorubicin cardiotoxicity: Innovative exploitation of the peculiar antipyroptotic/antioxidant/anti-inflammatory capacity via modulation of inflammasome/caspase-1/interleukin pathway in rats

Ahmedy, O. A., Salem, H. H., Mohamed, Y. S., & Zaky, D. A. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114964 · Cited by 4

Drp1 Proteins Released from Hydrolysis-Driven Scaffold Disassembly Trigger Nucleotide-Dependent Membrane Remodeling to Promote Scission

Luo, E. W.-C., Nolden, K. A., Alimohamadi, H., Lee, M. W., Duan, L., Hill, R. B., & Wong, G. C. L. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.4c15836 · Cited by 4

Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice

Huang, Q., Xiong, X., Chen, S., Wang, Y., Wang, L., Liu, W., Liu, C., Zeng, G., & Huang, Q. (2025) · Advanced Science · doi:10.1002/advs.202503259 · Cited by 4

Alteration of mitochondrial function in arthropods during arboviruses infection: a review of the literature

Santana-Román, M. E., Ramírez-Carreto, S., Maycotte, P., & Pando‐Robles, V. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1507059 · Cited by 4

ZnT6-mediated Zn2+ redistribution: impact on mitochondrial fission and autophagy in H9c2 cells

Tuncay, E., Olğar, Y., Aryan, L., Şık, S., Billur, D., & Turan, B. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05247-6 · Cited by 4

Baicalin Improves Skeletal Muscle Atrophy by Attenuating DRP-1-Mediated Mitochondrial Fission in Aged Mice

Mo, H. M. M., & Lee, J. H. (2025) · Muscles · doi:10.3390/muscles4030035 · Cited by 4

Down-regulation of HSPA9 reduces tyrosine hydroxylase-positive neurons in mouse substantia nigra and induces Parkinson’s disease-like motor impairments

Hyung, H., Jang, S., Kim, S., Bae, J.-E., Park, J. Y., Lim, S., Ko, J., Jang, S., Kim, J. B., Chae, H. Y., et al. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2569875 · Cited by 3

GPR40 agonist ameliorates neurodegeneration by regulating mitochondria dysfunction and NLRP3 inflammasome in Alzheimer’s disease animal models

Ha, T.-Y., Kim, Y., Lim, S. M., Hong, Y., & Chang, K. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118678 · Cited by 3

Cyclic tensile loading regulates nucleus pulposus cell autophagy through mitochondrial dynamics: molecular mechanisms and implications

Xue, S., & Samarkhazan, H. S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07932-6 · Cited by 3

Natriuretic peptides increase cGMP around cardiomyocyte mitochondria and protect against apoptosis

Calamera, G., Ndongson‐Dongmo, B., Arunthavarajah, D., Ovesen, M., Kim, J. J., Kim, C., Andressen, K. W., & Moltzau, L. R. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.08.080 · Cited by 3

Risk factors and predictive model for mortality in acute myocardial infarction with ventricular septal rupture at high altitudes

Zhang, L.-H., Cen, Z., Qiao, Q., Ye, X.-R., Cheng, L., Liu, G.-Q., Liu, Y., Zhang, X.-Q., Pan, X.-F., Zhang, H.-L., et al. (2025) · World Journal of Cardiology · doi:10.4330/wjc.v17.i7.109044 · Cited by 3

Sirtuins and cellular metabolism in cancers

Dong, Z., & Cui, H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822467-0.00008-5 · Cited by 3

Functional implications of rs9373441 with FOXP3+Treg and Tr1 for the clinical effectiveness of csDMARDs in rheumatoid arthritis

HSIEH, T.-Y., Lin, J., Liu, F., Chen, H., LUI, S.-W., & Chang, Y.-T. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117612 · Cited by 3

Mitochondrial Dysfunction in Traumatic Brain Injury: Management Strategies

Bonilla-Mendoza, C.-A., García-Ballestas, E., Pacheco-Hernández, A., Moscote‐Salazar, L. R., Keni, R. R., & Agrawal, A. (2020) · Indian Journal of Neurotrauma · doi:10.1055/s-0040-1713457 · Cited by 3

Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infectionPreprint

Achi, S. C., McGrosso, D., Tocci, S., Ibeawuchi, S., Sayed, I. M., Gonzalez, D. J., & Das, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.03.592405 · Cited by 3

Membrane ATPases and Mitochondrial Proteins in Fetal Cerebellum After Exposure to L-Glutamate During Gestation

Tejero, A., León, D., & Martı́n, M. (2025) · Membranes · doi:10.3390/membranes15050152 · Cited by 2

Mitochondrial dysfunction and defective quality control mechanisms in the kidney are not reversed by high-fat diet withdrawal in early obese mice

Braga, P. C., Vitorino, R. M. P., Ferreira, R. M., Marques, M., Oliveira, P. F., Rodrigues, A. S., & Alves, M. G. (2025) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2025.112635 · Cited by 2

Cardiac SR-Mitochondria Contacts—Impact on Cardiac Physiology and Mitochondrial Fitness

Fernández‐Sanz, C., Sheu, S., & de la Fuente, S. (2025) · Cells · doi:10.3390/cells14221762 · Cited by 2

Roles of DRP1 and the fission protein interactome as regulators of cellular stability and sarcopenia in skeletal muscle aging

Nivedya, C., Venkhatesh, P., Rodriguez, B. I., Le, H., Afolabi, J., Marshall, A., Neikirk, K., Masenga, S. K., Aftab, M., Kazma, L. J., et al. (2025) · Aging advances. · doi:10.4103/agingadv.agingadv-d-25-00013 · Cited by 2

Dimeric PKM2 in chondrocytes impairs mitochondrial homeostasis in osteoarthritis

Liu, B., Liang, Y., Wang, C., Weng, Z., Yang, Y., Shi, Y., & Zhang, C. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08621-4 · Cited by 2

Drp1–associated genes implicated in sepsis survival

Pokharel, M. D., Feng, A., Liang, Y., Ma, W., Aggarwal, S., Unwalla, H. J., Black, S. M., & Wang, T. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1516145 · Cited by 2

Validation of Active Compound of Terminalia catappa L. Extract and Its Anti-Inflammatory and Antioxidant Properties by Regulating Mitochondrial Dysfunction and Cellular Signaling Pathways

Paik, S. J., Kim, D.-S., Son, J. E., Bách, T. T., Hai, D. V., Paik, J., Jo, S., Kim, D. J., & Jung, S. K. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2407.07044 · Cited by 5

Enhanced Small Extracellular Vesicle Uptake by Activated Interneurons Improves Stroke Recovery in Mice

Wang, M., Liu, Z., Wang, W., Chopp, M., Millman, M., Li, Y., Cepparulo, P., Kemper, A., Li, C., Zhang, L., et al. (2025) · Journal of Extracellular Biology · doi:10.1002/jex2.70036 · Cited by 2

Proteome profiling indicates a link between mitochondrial pathways and the host-microbial sensor ELMO1 following Salmonella infection

Achi, S. C., McGrosso, D., Tocci, S., Amao, I. O., Saha, B., Ibeawuchi, S., Sayed, I. M., Gonzalez, D. J., & Das, S. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2580708 · Cited by 1

Mitochondria-targeting ACSL6 variant drives mitochondrial fragmentation potentially through local DHA-CoA production

Ota, R., Isobe, Y., Ohba, Y., & Arita, M. (2026) · Scientific Reports · doi:10.1038/s41598-026-46977-x · Cited by 1

Regulation of mitochondrial fission by Drp1 in cardiomyopathy: possible mechanisms linking cellular processes to cell death

Dubey, N., Panchbhai, P., Chaturvedi, G., Singh, S. N., Goyal, A., Parakh, N., Narang, R. A. J. I. V., Arava, S. K., Kumar, A., Yadav, M., et al. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11831-w · Cited by 1

HIV-1 Tat and gp120 as key drivers of neurodegeneration in the central nervous system

Cecchetto, R., Diani, E., Lotti, V., Palmisano, A., Lagni, A., Mantoan, M., Turrina, S., Raniero, D., Paolone, G., Mazzariol, A., et al. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1895162 · Cited by 2

Deficits in the Skeletal Muscle Transcriptome and Mitochondrial Coupling in Progressive Diabetes-Induced CKD Relate to Functional Decline

Bittel, D. C., Bittel, A. J., Varadhachary, A. S., Pietka, T., & Sinacore, D. R. (2021) · doi:10.2337/figshare.13643477 · Cited by 1

Natural and Synthetic GHSR1a Agonists as Neuroprotective Agents in Models of Parkinson's disease

Rees, D. J. (2017) · Cronfa (Swansea University) · doi:10.23889/suthesis.40946

Pathological Interaction between DNA Repair and Mitochondrial Dysfunction in ALS

Bermúdez-Guzmán, L., & Leal, A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.90217

Mitochondrial role in NAFLD as a chronic disease

Salva-Pastor, N., Domínguez‐Pérez, M., Chávez-Tapia, N. C., & Nuño‐Lámbarri, N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00006-1

Ginsenoside Rc Protects Neurons From Oxygen-glucose Deprivation Injuries and Its Mechanistic Investigation via a Network Pharmacology-based AnalysisPreprint

Huang, M., Chen, S., Zheng, K., Liu, Q., Li, K., Xian, M., & Wang, S. (2020) · Research Square · doi:10.21203/rs.3.rs-51034/v1

Integrated LC-MS/MS Method and Network Pharmacology for Exploring the Mechanism of Neuroprotective Effect of Ginsenoside Rc in Oxygen-Glucose Deprivation/Reperfusion Injury

Huang, M., Chen, S., Zheng, K., Liu, Q., Li, K., Xian, M., & Wang, S. (2021) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-021-00145-6

Hydrogen-Rich Medium Ameliorates Lipopolysaccharides-Induced Mitochondrial Fission and Dysfunction in Human Umbilical Vein Endothelial Cells (Huvecs) via Up-Regulating HO-1 ExpressionPreprint

Xie, K., Mao, X., Lian, N., Wang, Y., Wang, Y., Chen, H., Zhu, R., Yu, Y., & Wang, G. (2021) · Research Square · doi:10.21203/rs.3.rs-1020841/v1

B4; Monitoring & Passage Studies

Jacobson, P. (2011)

Skeletal muscle health in aging

Grevendonk, L. (2021) · Research Publications (Maastricht University) · doi:10.26481/dis.20211006lg

Early age changes in mRNA expression related to NAD-dependent enzymes and mitochondrial proteins in the brain cortex of an Alzheimer’s disease mouse modelPreprint

Żulińska, S., Wieczorek, I., Wencel, P., Strosznajder, R. P., Sun, G., & Strosznajder, J. B. (2022) · Research Square · doi:10.21203/rs.3.rs-1481945/v1

Deficits in the Skeletal Muscle Transcriptome and Mitochondrial Coupling in Progressive Diabetes-Induced CKD Relate to Functional Decline

Bittel, D. C., Bittel, A. J., Varadhachary, A. S., Pietka, T., & Sinacore, D. R. (2021) · doi:10.2337/figshare.13643477.v1

Inhibition of NF-κB Alleviates Ischemia-Induced Myocardial Apoptosis by Suppressing Drp1-Mediated Mitochondrial FissionPreprint

Kare, H., Luo, J., Liu, F., Zhang, T., Tian, T., Zhang, X.-H., Yang, Y., & Li, X. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4143209

Changes in transcription of genes encoding NAD-dependent enzymes and mitochondrial proteins in Alzheimer’s disease animal model. Indication of early targets in neuroprotectionPreprint

Żulińska, S., Wencel, P., Wieczorek, I., Strosznajder, R. P., & Strosznajder, J. B. (2023) · Research Square · doi:10.21203/rs.3.rs-2976047/v1

Characterization and contribution of RPE senescence to Age-related macular degeneration in Tnfrsf10 knock out micePreprint

Wada, I., Mori, K., Sreekumar, P. G., Ji, R., Spee, C. K., Hong, E., Ishikawa, K., Sonoda, K., & Kannan, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.04.552052

O papel do exercício físico no desequilíbrio mitonuclear e UPRmt na musculatura esquelética de camundongos idosos

Cordeiro, A. V. (2019) · doi:10.47749/t/unicamp.2019.1157580

Termogênese (adaptação ao frio e produção de calor) no adipócito marrom

Marinho, T. D. S., Reis‐Barbosa, P. H., Spezani, R., Marcondes‐de‐Castro, I. A., Santos-Reis, T., Petito‐da‐Silva, T. I., Bittencourt, J. D. O. A., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2023) · Anais da Academia Nacional de Medicina · doi:10.52130/27639878-aanm2023v194n1p52-65

Additional file 1 of Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Yuan, Z.-L., Mo, Y.-Z., Li, D.-L., Xie, L., & Chen, M. (2023) · Figshare · doi:10.6084/m9.figshare.23949717

Additional file 2 of Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD/R injury

Yuan, Z.-L., Mo, Y.-Z., Li, D.-L., Xie, L., & Chen, M. (2023) · Figshare · doi:10.6084/m9.figshare.23949723

Triterpenoids Extracted and Purified from Forsythia Suspensa Leaves Induce Breast Cancer Cell Apoptosis Via the Mitochondrial PathwayPreprint

Xiao, L., Wang, X., Chen, L., Ning, E., Li, Z., Zhang, L., Yu, L., Wei, Y., Zhang, L., Chang, X., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4865362

Mitochondrial dynamics and sex-specific responses in the developing rat hippocampus: Effect of perinatal asphyxia and mesenchymal stem cell Secretome treatment

Zamorano-Cataldo, M., Vega-Vásquez, I., García‐Navarrete, C., Toledo, J., Bustamante, D., Ezquer, F. E., Urra, F. A., Farfán-Troncoso, N., HERRERA‐MARSCHITZ, M., & Morales, P. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119851

Sphingolipid metabolism in the regulation of mitophagy: implications in cancer therapy, immune cell function, and neurodegeneration

Kassir, M. F., & Öğretmen, B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00005-3

Drp1 promotes vascular smooth muscle cell death via adverse mitochondrial dynamicsPreprint

Patel, V. B., Jadli, A. S., Meechem, M. B., Gomes, K., Mackay, C. D. A., Edalat, P., & Palma, C. D. (2025) · Research Square · doi:10.21203/rs.3.rs-5968820/v1

Long-read sequencing-based atlas of tissue-specific expression of Drp1 transcript variantsPreprint

Yan, F., Jabbari, J. S., Ling, N. X. Y., Kong, A. M., Truong, J. Q., Rosdah, A. A., Langendorf, C. G., Zhang, L., Lees, J. G., Bass-Stringer, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.06.680828

Importance of β-Catenin and DRP-1 Expression in Hepatocellular Carcinomas

Özmen, S., Demirci, E., Demirtaş, R., Ceylan, O., Esin, K. Ü., Kara, S., Aksungur, N., Altundaş, N., Alper, F., Dursun, H., et al. (2025) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.1666393

Aurora-A-mediated cytosolic localization of Maf1 promotes cell proliferation via regulating mitochondrial function in HCC

Yang, S.-J., Kuan, Y.-H., Ooi, Z.-X., Lai, H.-S., Wu, H., Liao, P., Lin, Y.-J., Su, C. M., Lai, M., & Hung, L. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02885-z

Additional file 2 of Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model

Menzie, J., Modi, J., Xu, H., Bent, A., Trujillo, P., Medley, K., Jimenez, E., Shen, J., Marshall, M., Tao, R., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13172963

Additional file 3 of Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model

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Additional file 1 of Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model

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