Cited by 303Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

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Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

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Hu, Chenxia, Huang, Yong, Li, Lanjuan·2017·International Journal of Molecular Sciences

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Abstract

Current research has demonstrated that mitochondrial morphology, distribution, and function are maintained by the balanced regulation of mitochondrial fission and fusion, and perturbation of the homeostasis between these processes has been related to cell or organ dysfunction and abnormal mitochondrial redistribution. Abnormal mitochondrial fusion induces the fragmentation of mitochondria from a tubular morphology into pieces; in contrast, perturbed mitochondrial fission results in the fusion of adjacent mitochondria. A member of the dynamin family of large GTPases, dynamin-related protein 1 (Drp1), effectively influences cell survival and apoptosis by mediating the mitochondrial fission process in mammals. Drp1-dependent mitochondrial fission is an intricate process regulating both cellular and organ dynamics, including development, apoptosis, acute organ injury, and various diseases. Only after clarification of the regulative mechanisms of this critical protein in vivo and in vitro will it set a milestone for preventing mitochondrial fission related pathological processes and refractory diseases.

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Authors: Hu, C., Huang, Y., & Li, L.
Affiliations: First Affiliated Hospital Zhejiang University (CN)
Corresponding author: Li, Lanjuan
ORCID: Hu, Chenxia
Huang, Yong
Li, Lanjuan
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2017-01-13
Volume: 18
Issue: 1
Pages: 144
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms18010144
PMC: PMC5297777
OpenAlex: W2573555074
Cited by: 302
References: 144
Citations by year: 2026: 27 · 2025: 34 · 2024: 33 · 2023: 32 · 2022: 29 · 2021: 36 · 2020: 35 · 2019: 27 · 2018: 28 · 2017: 18
FWCI: 2.76
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81471794, 10002004, 81121002)
Science Fund for Creative Research Groups
National Science and Technology Major Project (2012ZX10002004)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: Drp1, mitochondrial fission, mitochondrial fusion, mitochondrial morphology, apoptosis, mitochondrial distribution, organ damage, mitochondrial homeostasis, mitochondrial disease
MeSH terms: Animals, Disease, Humans, Mammals, Protein Processing, Post-Translational, Apoptosis, Dynamins, Mitochondrial Dynamics

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Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals

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