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Cited by 164Lymphatic System and DiseasesLymphatic Disorders and TreatmentsParasitic Diseases Research and Treatment

Inflammatory manifestations of lymphedema

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Ly, Catherine, Kataru, Raghu, Mehrara, Babak·2017·International Journal of Molecular Sciences
DOI 10.3390/ijms18010171PMC PMC5297803
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Abstract

Lymphedema results from lymphatic insufficiency leading to a progressive inflammatory process that ultimately manifests as discomfort, recurrent infections, and, at times, secondary malignancy. Collectively, these morbidities contribute to an overall poor quality of life. Although there have been recent advances in microsurgical interventions, a conservative palliative approach remains the mainstay of treatment for this disabling disease. The absence of a cure is due to an incomplete understanding of the pathophysiological changes that result in lymphedema. A histological hallmark of lymphedema is inflammatory cell infiltration and recent studies with animal models and clinical biopsy specimens have suggested that this response plays a key role in the pathology of the disease. The purpose of this report is to provide an overview of the ongoing research in and the current understanding of the inflammatory manifestations of lymphedema.

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  • A common manifestation of lymphatic insufficiency is tissue fibrosis, and its progression may in turn further impair lymphatic function.

    “A common manifestation of lymphatic insufficiency is tissue fibrosis, and its progression may in turn further impair lymphatic function (139).”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [139]

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Cited by

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Authors
Ly, C., Kataru, R., & Mehrara, B.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Mehrara, Babak
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2017-01-17
Volume
18
Issue
1
Pages
171
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms18010171
PMC
PMC5297803
OpenAlex
W2573176225
Cited by
164
References
4
Citations by year
2026: 18 · 2025: 13 · 2024: 22 · 2023: 16 · 2022: 25 · 2021: 20 · 2020: 22 · 2019: 15 · 2018: 10 · 2017: 3
FWCI
1.43
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Institutes of Health (T32 CA9501-29, R01 HL111130-01)
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
lymphedema, lymphatic insufficiency, inflammation, inflammatory cell infiltration, secondary malignancies, lymphedema treatment, quality of life
MeSH terms
Animals, Dendritic Cells, Disease Models, Animal, Humans, Inflammation, Lymphatic System, Lymphedema, Macrophages, CD4-Positive T-Lymphocytes, Cytokines

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