Dendritic-cell trafficking to lymph nodes through lymphatic vessels
Open accessAbstract
Antigen-presenting dendritic cells often acquire foreign antigens in peripheral tissues such as the skin. Optimal encounter with naive T cells for the presentation of these antigens requires that the dendritic cells migrate to draining lymph nodes through lymphatic vessels. In this article, we review important aspects of what is known about dendritic-cell trafficking into and through lymphatic vessels to lymph nodes. We present these findings in the context of information about lymphatic-vessel biology. Gaining a better understanding of the crosstalk between dendritic cells and lymphatic vessels during the migration of dendritic cells to lymph nodes is essential for future advances in manipulating dendritic-cell migration as a means to fine-tune immune responses in clinical settings.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mouse DCs start to enter the regional lymph node 18 hours after inoculation in the skin, reaching a maximum within 72 hours.
“Mouse DCs start to enter the regional lymph node 18 hours after inoculation in the skin, reaching a maximum within 72 hours.50,51”
From Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells (2006) · cites this paper as [51]
Cited by
Sorted by citations
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309 · see citing works
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625 · see citing works
High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
Bianchi, M. E., & Manfredi, A. A. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00574.x · Cited by 600 · see citing works
Cheng, K., Zhao, R., Li, Y., Qi, Y., Wang, Y., Zhang, Y., Qin, H., Qin, Y., Chen, L., Li, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22308-8 · Cited by 480 · see citing works
Agrawal, A., Agrawal, S., Cao, J.-N., Su, H., Osann, K., & Gupta, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6912 · Cited by 435 · see citing works
Greter, M., Helft, J., Chow, A., Hashimoto, D., Mortha, A., Agudo-Cantero, J., Bogunovic, M., Gautier, E. L., Miller, J., Leboeuf, M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.027 · Cited by 433 · see citing works
Self-citationMicrobiome-Driven Allergic Lung Inflammation Is Ameliorated by Short-Chain Fatty Acids
Cait, A., Hughes, M. R., Antignano, F., Cait, J., Dimitriu, P. A., Maas, K. R., Reynolds, L. A., Hacker, L., Mohr, J., Finlay, B. B., et al. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.75 · Cited by 394 · see citing works
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, L. A., Clasper, S., Holt, A. P., Lalor, P. F., Baban, D., & Jackson, D. G. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051759 · Cited by 346 · see citing works
Holland, D., Booy, R., Looze, F. D., Eizenberg, P., McDonald, J., Karrasch, J., McKeirnan, M., Salem, H., Mills, G., Reid, J., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/590434 · Cited by 254 · see citing works
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II
Takamatsu, H., Takegahara, N., Nakagawa, Y., Tomura, M., Taniguchi, M., Friedel, R. H., Rayburn, H., Tessier-Lavigne, M., Yoshida, Y., Okuno, T., et al. (2010) · Nature Immunology · doi:10.1038/ni.1885 · Cited by 288 · see citing works
Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber
Haessler, U., Teo, J. C. M., Foretay, D., Renaud, P., & Swartz, M. A. (2012) · Integrative Biology · doi:10.1039/c1ib00128k · Cited by 176 · see citing works
Self-citationSodium in the microenvironment regulates immune responses and tissue homeostasis
Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149 · see citing works
Lymphatic function and immune regulation in health and disease
Liao, S., & Padera, T. P. (2013) · Lymphatic Research and Biology · doi:10.1089/lrb.2013.0012 · Cited by 122 · see citing works
3D Immunocompetent Organ‐on‐a‐Chip Models
Maharjan, S., Cecen, B., & Zhang, Y. S. (2020) · Small Methods · doi:10.1002/smtd.202000235 · Cited by 62 · see citing works
A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
Sun, T., Yang, L., Kaur, H., Pestel, J., Looso, M., Nolte, H., Krasel, C., Heil, D., Krishnan, R. K., Santoni, M.-J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201602002 · Cited by 44 · see citing works
- Authors
- Randolph, G. J., Angeli, V., & Swartz, M. A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- École Polytechnique Fédérale de Lausanne (CH)
- Venue
- Nature Reviews Immunology
- Published
- 2005-08
- Volume
- 5
- Issue
- 8
- Pages
- 617-628
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2037380046
- Cited by
- 1,111
- References
- 0
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 29 · 2023: 41 · 2022: 46 · 2021: 39 · 2020: 46 · 2019: 58 · 2018: 57 · 2017: 60 · 2016: 60 · 2015: 54 · 2014: 72 · 2013: 78 · 2012: 53
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
- Keywords
- dendritic cells, dendritic cell migration, lymphatic vessels, lymph node trafficking, antigen presentation, naive T cells, immunomodulation
- MeSH terms
- Animals, Chemotaxis, Dendritic Cells, Humans, Immunologic Factors, Lymph Nodes, Chemokines, Lymphatic Vessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
