The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
Chronic Kidney Disease and Exposure to Nephrotoxic Metals
Open accessAbstract
Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chronic kidney disease: global dimension and perspectives
Jha, V., Garcia-Garcia, G., Iseki, K., Li, Z., Naicker, S., Plattner, B., Saran, R., Wang, A. Y.-M., & Yang, C.-W. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60687-x · Cited by 4,383
The Toxicology of Mercury and Its Chemical Compounds
Clarkson, T. W., & Magos, L. (2006) · Critical Reviews in Toxicology · doi:10.1080/10408440600845619 · Cited by 2,371
Leslie, E. M., Deeley, R. G., & Cole, S. P. C. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.10.012 · Cited by 1,406
Cancer registries in environmental cancer epidemiology
Teppo, L. (1998) · Scandinavian Journal of Work, Environment & Health · doi:10.5271/sjweh.270 · Cited by 1,248
Styblo, M., Del Razo, L. M., Vega, L., Germolec, D. R., LeCluyse, E. L., Hamilton, G. A., Reed, W., Wang, C., Cullen, W. R., & Thomas, D. J. (2000) · Archives of Toxicology · doi:10.1007/s002040000134 · Cited by 998
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
Yeung, K., Seitz, T., Li, S., Janosch, P., McFerran, B., Kaiser, C., Fee, F., Katsanakis, K. D., Rose, D. W., Mischak, H., et al. (1999) · Nature · doi:10.1038/43686 · Cited by 893
TOXIC AND ESSENTIAL METAL INTERACTIONS
Goyer, R. A. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.37 · Cited by 791
Prevalence of Skin Cancer in an Endemic Area of Chronic Arsenicism in Taiwan 2
(1968) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/40.3.453 · Cited by 787
Heavy metal poisoning: the effects of cadmium on the kidney
Johri, N., Jacquillet, G., & Unwin, R. (2010) · BioMetals · doi:10.1007/s10534-010-9328-y · Cited by 750
Monomethylarsonous Acid (MMAIII) Is More Toxic Than Arsenite in Chang Human Hepatocytes
Petrick, J. S., Ayala-Fierro, F., Cullen, W. R., Carter, D. E., & Vasken Aposhian, H. (2000) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8872 · Cited by 716
Cited by
Clinical and molecular aspects of lead toxicity: An update
Mitra, P., Sharma, S., Purohit, P., & Sharma, P. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1408562 · Cited by 389
AL-Megrin, W. A., Soliman, D., Kassab, R. B., Metwally, D. M., Moneim, A. E. A., & El-Khadragy, M. F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00064 · Cited by 84
Metadata
- Authors
- Orr, S., & Bridges, C.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-05-12
- Volume
- 18
- Issue
- 5
- Pages
- 1039
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2612996853
- Cited by
- 434
- References
- 221
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chronic Kidney Disease and Exposure to Nephrotoxic Metals. https://app.cochat.ai/papers/10.3390/ijms18051039
- The paper
- Orr, S., & Bridges, C. (2017). Chronic Kidney Disease and Exposure to Nephrotoxic Metals. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18051039
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
