The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases
Open accessAbstract
Glutamine, the most abundant free amino acid in the human body, is a major substrate utilized by intestinal cells. The roles of glutamine in intestinal physiology and management of multiple intestinal diseases have been reported. In gut physiology, glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions. As glutamine stores are depleted during severe metabolic stress including trauma, sepsis, and inflammatory bowel diseases, glutamine supplementation has been examined in patients to improve their clinical outcomes. In this review, we discuss the physiological roles of glutamine for intestinal health and its underlying mechanisms. In addition, we discuss the current evidence for the efficacy of glutamine supplementation in intestinal diseases.
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α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer
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Metadata
- Authors
- Kim, M.-H., & Kim, H.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-05-12
- Volume
- 18
- Issue
- 5
- Pages
- 1051
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2613613095
- Cited by
- 371
- References
- 132
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
