The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
Open accessAbstract
Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
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Cites
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754
Gupta, S., Hirota, M., Waugh, S. M., Murakami, I., Suzuki, T., Muraguchi, M., Shibamori, M., Ishikawa, Y., Jarvis, T. C., Carter, J. D., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.532580 · Cited by 151
Cited by
RNA-based therapeutics: an overview and prospectus
Zhu, Y., Zhu, L., Wang, X., & Jin, H. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05075-2 · Cited by 623
Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives
Li, L., Xu, S., Yan, H., Li, X., Yazd, H. S., Li, X., Huang, T., Cui, C., Jiang, J., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202003563 · Cited by 432
SELEX: Critical factors and optimization strategies for successful aptamer selection
Kohlberger, M., & Gadermaier, G. (2022) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2244 · Cited by 341
Empowering Exosomes with Aptamers for Precision Theranostics
Zheng, L., Li, J., Li, Y., Sun, W., Ma, L., Qu, F., & Tan, W. (2025) · Small Methods · doi:10.1002/smtd.202400551 · Cited by 21
Through the looking glass: milestones on the road towards mirroring life
Rohden, F., Hoheisel, J. D., & Wieden, H.-J. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.06.006 · Cited by 18
Metadata
- Authors
- Ni, S., Yao, H., Wang, L., Lu, J., Jiang, F., Lu, A., & Zhang, G.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-08-02
- Volume
- 18
- Issue
- 8
- Pages
- 1683
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2740994733
- Cited by
- 321
- References
- 2
- FWCI
- 11.74
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ni, S., Yao, H., Wang, L., Lu, J., Jiang, F., Lu, A., & Zhang, G. (2017). Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18081683
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