The DOI matches its Crossref record; 167 of the 167 references it cites were found in a registry or an index.
RNA-based therapeutics: an overview and prospectus
Open accessAbstract
The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto “undruggable” proteins, transcripts and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been approved for clinical use, while others are still under investigation or preclinical trials. Various techniques have been explored to promote RNA intracellular trafficking and metabolic stability, despite significant challenges in developing RNA-based therapeutics. In this review, the mechanisms of action, challenges, solutions, and clinical application of RNA-based therapeutics have been comprehensively summarized.
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Cites
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The landscape of nanoparticle-based siRNA delivery and therapeutic development
Moazzam, M., Zhang, M., Hussain, A., Yu, X., Huang, J., & Huang, Y. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.01.005 · Cited by 230
RNA editing: Expanding the potential of RNA therapeutics
Booth, B. J., Nourreddine, S., Katrekar, D., Savva, Y., Bose, D., Long, T. J., Huss, D. J., & Mali, P. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.01.005 · Cited by 171
Has AlphaFold 3 achieved success for RNA?
Bernard, C., Postic, G., Ghannay, S., & Tahi, F. (2025) · Acta Crystallographica Section D Structural Biology · doi:10.1107/s2059798325000592 · Cited by 61
State-of-the-RNArt: benchmarking current methods for RNA 3D structure prediction
Bernard, C., Postic, G., Ghannay, S., & Tahi, F. (2024) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqae048 · Cited by 40
Szikszai, M., Magnus, M., Sanghi, S., Kadyan, S., Bouatta, N., & Rivas, E. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168552 · Cited by 38
Metadata
- Authors
- Zhu, Y., Zhu, L., Wang, X., & Jin, H.
- Venue
- Cell Death & Disease
- Published
- 2022-07-23
- Volume
- 13
- Issue
- 7
- Pages
- 644-644
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W4286721853
- Cited by
- 623
- References
- 167
- FWCI
- 34.53
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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