The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Estrogen Effects on Wound Healing
Open accessAbstract
Wound healing is a physiological process, involving three successive and overlapping phases—hemostasis/inflammation, proliferation, and remodeling—to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.
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In the citing paper
“In fact, estrogen is found to be involved in all phases of wound healing27.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
In the citing paper
“estrogen is very important to wound healing27,28”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
In the citing paper
“Indeed, peripheral tissues produce estrogens71, and estrogens play a vital role in wound healing27,28.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [27]
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Citations
Cites
Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
Gauglitz, G. G., Korting, H. C., Pavicic, T., Ruzicka, T., & Jeschke, M. G. (2011) · Molecular Medicine · doi:10.2119/molmed.2009.00153 · Cited by 1,462
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291
Diabetes and Wound Angiogenesis
Okonkwo, U. A., & DiPietro, L. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071419 · Cited by 1,071
Estrogen receptors regulate innate immune cells and signaling pathways
Kovats, S. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.01.018 · Cited by 1,021
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis
Ogawa, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030606 · Cited by 985
Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing
Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852
Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment
Berman, B., Maderal, A. D., & Raphael, B. A. (2016) · Dermatologic Surgery · doi:10.1097/dss.0000000000000819 · Cited by 715
Regeneration of fat cells from myofibroblasts during wound healing
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science · doi:10.1126/science.aai8792 · Cited by 584
Khan, D., & Ahmed, S. A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00635 · Cited by 475
Understanding fibroblast heterogeneity in the skin
Driskell, R. R., & Watt, F. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.10.001 · Cited by 425
Cited by
Sorted by citations
Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies
Gushiken, L. F. S., Beserra, F. P., Bastos, J. K., Jackson, C. J., & Pellizzon, C. H. (2021) · Life · doi:10.3390/life11070665 · Cited by 332
The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection
Harding, A. T., & Heaton, N. S. (2022) · Cancers · doi:10.3390/cancers14040909 · Cited by 278
Current Approaches Targeting the Wound Healing Phases to Attenuate Fibrosis and Scarring
Ayadi, A. E., Jay, J. W., & Prasai, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031105 · Cited by 262
Prasathkumar, M., & Sadhasivam, S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.067 · Cited by 223
Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision
Lee, W.-L., Liu, C., Cheng, M., Chang, W.-H., Liu, W., & Wang, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105175 · Cited by 215
Self-citation
Metadata
- Authors
- Horng, H.-C., Chang, W.-H., Yeh, C.-C., Huang, B.-S., Chang, C.-P., Chen, Y.-J., Tsui, K.-H., & Wang, P.-H.
- Affiliations
- Taipei Veterans General Hospital (TW)
- Tajen University (TW)
- Corresponding author
- Wang, Peng-Hui
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2017-11-03
- Volume
- 18
- Issue
- 11
- Pages
- 2325
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5713294
- OpenAlex
- W2765643716
- Cited by
- 208
- References
- 107
- Citations by year
- 2026: 23 · 2025: 33 · 2024: 27 · 2023: 25 · 2022: 25 · 2021: 24 · 2020: 27 · 2019: 17 · 2018: 7
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Taipei Veterans General Hospital (V104C-095, V106C-129; V106D23-001-MY2-1, V105C-096, V106C-129, V106A-012, V106D23-001-MY2-1)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- estrogen, wound healing, estrogen deficiency, postmenopausal women, skin homeostasis, inflammation, re-epithelialization, hemostasis, tissue remodeling, estrogen therapy
- MeSH terms
- Animals, Estrogens, Hemostasis, Humans, Inflammation, Receptors, Estrogen, Wound Healing, Signal Transduction, Cell Proliferation, Drug Discovery
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