Cited by 584Wound Healing and TreatmentsHair Growth and DisordersDermatologic Treatments and Research

Regeneration of fat cells from myofibroblasts during wound healing

Open access
Plikus, Maksim V., Guerrero-Juarez, Christian F., Ito, Mayumi, Li, Yun Rose, Dedhia, Priya H., Zheng, Ying, Shao, Mengle, Gay, Denise L. +30 more·2017·Science

Abstract

Hair follicles: Secret to prevent scars?: Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus et al. now show that hair follicles in both mice and humans can convert myofibroblasts, the predominant dermal cell in a wound, into adipocytes (see the Perspective by Chan and Longaker). The hair follicles activated the bone morphogenetic protein (BMP) signaling pathway and adipocyte transcription factors in the myofibroblast. Thus, it may be possible to reduce scar formation after wounding by adding BMP. Science , this issue p. 748 ; see also p. 693

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1126/science.aai8792

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Increased glycolysis has been implicated in experimental lung, liver, and kidney fibrosis models, and inhibition of glycolysis reduces extracellular matrix accumulation.

    “Increased glycolysis has been implicated in experimental lung, liver and kidney fibrosis models and inhibition of glycolysis reduces ECM accumulation50–52.”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [50]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., Oh, J. W., Wang, X., Ramirez, A., Konopelski, S. E., Elzein, A., Wang, A., Supapannachart, R. J., Lee, H.-L., Lim, C. H., Nace, A., Guo, A., Treffeisen, E., Andl, T., Ramirez, R. N., Murad, R., Offermanns, S., Metzger, D., Chambon, P., Widgerow, A. D., Tuan, T.-L., Mortazavi, A., Gupta, R. K., Hamilton, B. A., Millar, S. E., Seale, P., Pear, W. S., Lazar, M. A., & Cotsarelis, G.
Affiliations
  • University of California, Irvine (US)
  • Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
  • New York University (US)
  • University of Pennsylvania (US)
  • The University of Texas Southwestern Medical Center (US)
  • Inserm (FR)
  • University of Central Florida (US)
  • Max Planck Institute for Heart and Lung Research (DE)
  • Centre National de la Recherche Scientifique (FR)
  • University of Southern California (US)
  • University of California San Diego (US)
Corresponding author
  • Plikus, Maksim V.
  • Cotsarelis, George
Venue
Science
Published
2017-02-17
Volume
355
Issue
6326
Pages
748-752
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2568092366
Cited by
584
References
110
Citations by year
2026: 47 · 2025: 58 · 2024: 53 · 2023: 73 · 2022: 74 · 2021: 66 · 2020: 69 · 2019: 54 · 2018: 60 · 2017: 28
FWCI
54.93
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion, other-oa)
  • Journal of International Crisis and Risk Communication Research (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Science Foundation (award295757, DGE-1321846)
  • National Cancer Institute (award295758, T32-CA009054)
  • National Institute of General Medical Sciences (award295759, R01-GM095821,R25-GM055246)
  • National Institute of Diabetes and Digestive and Kidney Diseases (award295760, P30-DK019525,P01-DK049210)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (award295761, R01-AR055309,P30-AR057217,R01-AR067273,R01-AR069653)
  • Pew Charitable Trusts (award295762)
  • California Institute for Regenerative Medicine (award295763, TG2-01152)
  • Dermatology Foundation (award295764)
  • Canadian Institutes of Health Research (award295765, MFE-123724)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Urology › Hair Growth and Disorders
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
scar formation, wound healing, hair follicle, myofibroblasts, adipogenesis, adipose tissue regeneration, BMP signaling, dermal cells
MeSH terms
Animals, Cells, Cultured, Cicatrix, DNA-Binding Proteins, Fibroblasts, Humans, Mice, Inbred C57BL, Recombinant Proteins, Regeneration, Transcription Factors, Wound Healing, Signal Transduction, Adipocytes, Hair Follicle, Bone Morphogenetic Proteins, Mice, Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 4, Myofibroblasts, Cellular Reprogramming

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review