Regeneration of fat cells from myofibroblasts during wound healing
Open accessAbstract
Hair follicles: Secret to prevent scars?: Although some animals easily regenerate limbs and heal broken flesh, mammals are generally not so gifted. Wounding can leave scars, which are characterized by a lack of hair follicles and cutaneous fat. Plikus et al. now show that hair follicles in both mice and humans can convert myofibroblasts, the predominant dermal cell in a wound, into adipocytes (see the Perspective by Chan and Longaker). The hair follicles activated the bone morphogenetic protein (BMP) signaling pathway and adipocyte transcription factors in the myofibroblast. Thus, it may be possible to reduce scar formation after wounding by adding BMP. Science , this issue p. 748 ; see also p. 693
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased glycolysis has been implicated in experimental lung, liver, and kidney fibrosis models, and inhibition of glycolysis reduces extracellular matrix accumulation.
“Increased glycolysis has been implicated in experimental lung, liver and kidney fibrosis models and inhibition of glycolysis reduces ECM accumulation50–52.”
From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179 · see citing works
Full-length RNA-seq from single cells using Smart-seq2
Picelli, S., Faridani, O. R., Björklund, Å. K., Winberg, G., Sagasser, S., & Sandberg, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.006 · Cited by 4,137 · see citing works
Smart-seq2 for sensitive full-length transcriptome profiling in single cells
Picelli, S., Björklund, Å. K., Faridani, O. R., Sagasser, S., Winberg, G., & Sandberg, R. (2013) · Nature Methods · doi:10.1038/nmeth.2639 · Cited by 2,358 · see citing works
Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876 · see citing works
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291 · see citing works
White Fat Progenitor Cells Reside in the Adipose Vasculature
Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D., & Graff, J. M. (2008) · Science · doi:10.1126/science.1156232 · Cited by 1,113 · see citing works
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064 · see citing works
Self-citationLee, K., Kim, H., Li, Q., Chi, X., Ueta, C., Komori, T., Wozney, J. M., Kim, E., Choi, J.-Y., Ryoo, H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8783-8792.2000 · Cited by 867 · see citing works
Lefebvre, V., Li, P., & de Crombrugghe, B. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5718 · Cited by 811 · see citing works
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works
Self-citationIdentification and isolation of a dermal lineage with intrinsic fibrogenic potential
Rinkevich, Y., Walmsley, G. G., Hu, M. S.-M., Maan, Z. N., Newman, A. M., Drukker, M., Januszyk, M., Krampitz, G. W., Gurtner, G. C., Lorenz, H. P., et al. (2015) · Science · doi:10.1126/science.aaa2151 · Cited by 695 · see citing works
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation
Smas, C. M., & Sul, H. S. (1993) · Cell · doi:10.1016/0092-8674(93)90252-l · Cited by 677 · see citing works
G12-G13–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension
Wirth, A., Benyó, Z., Lukasova, M., Leutgeb, B., Wettschureck, N., Gorbey, S., Örsy, P., Horváth, B., Maser‐Gluth, C., Greiner, E. F., et al. (2007) · Nature Medicine · doi:10.1038/nm1666 · Cited by 671 · see citing works
Self-citationProminin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
Zhu, L., Gibson, P., Currle, D. S., Tong, Y., Richardson, R. J., Bayazitov, I. T., Poppleton, H., Zakharenko, S. S., Ellison, D. W., & Gilbertson, R. J. (2008) · Nature · doi:10.1038/nature07589 · Cited by 668 · see citing works
Ng, L. J., Wheatley, S. C., Muscat, G. E. O., Conway-Campbell, J., Bowles, J., Wright, E. M., Bell, D. M., Tam, P., Cheah, K. S. E., & Koopman, P. A. (1997) · Developmental Biology · doi:10.1006/dbio.1996.8487 · Cited by 667 · see citing works
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
Wright, E. M., Hargrave, M. R., Christiansen, J. H., Cooper, L. T., Kun, J., Evans, T. M., Gangadharan, U., Greenfield, A., & Koopman, P. A. (1995) · Nature Genetics · doi:10.1038/ng0195-15 · Cited by 661 · see citing works
Hinz, B., Mastrangelo, D., Iselin, C. E., Chaponnier, C., & Gabbiani, G. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61776-2 · Cited by 638 · see citing works
Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements
Lepper, C., Conway, S. J., & Fan, C. (2009) · Nature · doi:10.1038/nature08209 · Cited by 580 · see citing works
Skin shedding and tissue regeneration in African spiny mice (Acomys)
Seifert, A. W., Kiama, S. G., Seifert, M. G., Goheen, J. R., Palmer, T. M., & Maden, M. (2012) · Nature · doi:10.1038/nature11499 · Cited by 556 · see citing works
Transcriptional control of preadipocyte determination by Zfp423
Gupta, R. K., Arany, Z. P., Seale, P., Mepani, R. J., Li, Y., Conroe, H. M., Roby, Y. A., Kulaga, H. M., Reed, R. R., & Spiegelman, B. M. (2010) · Nature · doi:10.1038/nature08816 · Cited by 537 · see citing works
Self-citationConesa, A., Nueda, M. J., Ferrer, A., & Talón, M. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl056 · Cited by 476 · see citing works
Dermal adipocytes protect against invasive <i>Staphylococcus aureus</i> skin infection
Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471 · see citing works
Self-citationMice Lacking Paternally Expressed Pref-1/Dlk1 Display Growth Retardation and Accelerated Adiposity
Moon, Y. S., Smas, C. M., Lee, K., Villena, J. A., Kim, K., Yun, E. J., & Sul, H. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.15.5585-5592.2002 · Cited by 462 · see citing works
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
Mori–Akiyama, Y., Akiyama, H., Rowitch, D. H., & Crombrugghe, B. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1631288100 · Cited by 429 · see citing works
Gupta, R. K., Mepani, R. J., Kleiner, S., Lo, J. C., Khandekar, M. J., Cohen, P., Frontini, A., Bhowmick, D. C., Ye, L., Cinti, S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.010 · Cited by 426 · see citing works
Self-citationDulauroy, S., Di Carlo, S. E., Langa, F., Eberl, G., & Peduto, L. (2012) · Nature Medicine · doi:10.1038/nm.2848 · Cited by 418 · see citing works
Miano, J. M., Cserjesi, P., Ligon, K. L., Periasamy, M., & Olson, E. N. (1994) · Circulation Research · doi:10.1161/01.res.75.5.803 · Cited by 407 · see citing works
Philpott, M. P., Green, M. R., & Kealey, T. (1990) · Journal of Cell Science · doi:10.1242/jcs.97.3.463 · Cited by 393 · see citing works
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip
Rinkevich, Y., Lindau, P., Ueno, H., Longaker, M. T., & Weissman, I. L. (2011) · Nature · doi:10.1038/nature10346 · Cited by 391 · see citing works
Inducible lineage tracing of Pax7‐descendant cells reveals embryonic origin of adult satellite cells
Lepper, C., & Fan, C. (2010) · genesis · doi:10.1002/dvg.20630 · Cited by 377 · see citing works
SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
Biernaskie, J., Paris, M., Morozova, O., Fagan, B. M., Marra, M. A., Pevny, L., & Miller, F. D. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.10.019 · Cited by 357 · see citing works
Next maSigPro: updating maSigPro bioconductor package for RNA-seq time series
Nueda, M. J., Tarazona, S., & Conesa, A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu333 · Cited by 348 · see citing works
Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis
Mori, T., Sakaue, H., Iguchi, H., Gomi, H., Okada, Y., Takashima, Y., Nakamura, K., Nakamura, T., Yamauchi, T., Kubota, N., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410515200 · Cited by 340 · see citing works
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331 · see citing works
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding
Gay, D. L., Kwon, O., Zhang, Z., Spata, M., Plikus, M. V., Holler, P. D., Ito, M., Yang, Z., Treffeisen, E. R., Kim, C. D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3181 · Cited by 319 · see citing works
Self-citationInhibition of Bmp signaling affects growth and differentiation in the anagen hair follicle
Kulessa, H., Turk, G., & Hogan, B. L. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6664 · Cited by 303 · see citing works
Core-binding factor β interacts with Runx2 and is required for skeletal development
Yoshida, C. A., Furuichi, T., Fujita, T., Fukuyama, R., Kanatani, N., Kobayashi, S., Satake, M., Takada, K., & Komori, T. (2002) · Nature Genetics · doi:10.1038/ng1015 · Cited by 283 · see citing works
Lee, K., Villena, J. A., Moon, Y. S., Kim, K., Lee, S., Kang, C., & Sul, H. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15924 · Cited by 264 · see citing works
Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms
Kennell, J. A., & MacDougald, O. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501080200 · Cited by 253 · see citing works
Zheng, Y., Du, X., Wang, W., Boucher, M., Parimoo, S., & Stenn, K. S. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23716.x · Cited by 232 · see citing works
Self-citationCbfβ interacts with Runx2 and has a critical role in bone development
Kundu, M., Javed, A., Jeon, J., Horner, A. A., Shum, L., Eckhaus, M., Muenke, M., Lian, J. B., Yang, Y., Nuckolls, G. H., et al. (2002) · Nature Genetics · doi:10.1038/ng1050 · Cited by 222 · see citing works
Mouse digit tip regeneration is mediated by fate-restricted progenitor cells
Lehoczky, J. A., Robert, B., & Tabin, C. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118017108 · Cited by 218 · see citing works
Sennett, R., Wang, Z., Rezza, A., Grisanti, L., Roitershtein, N., Sicchio, C., Mok, K. W., Heitman, N. J., Clavel, C., Ma’ayan, A., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.023 · Cited by 211 · see citing works
Cleavage of Membrane-Associated pref-1 Generates a Soluble Inhibitor of Adipocyte Differentiation
Smas, C. M., Chen, L., & Sul, H. S. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.977 · Cited by 206 · see citing works
Rezza, A., Wang, Z., Sennett, R., Qiao, W., Wang, D., Heitman, N., Mok, K. W., Clavel, C., Yi, R., Zandstra, P., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.078 · Cited by 197 · see citing works
Hamidouche, Z., Haÿ, E., Vaudin, P., Charbord, P., Schüle, R., Marie, P. J., & Fromigué, O. (2008) · The FASEB Journal · doi:10.1096/fj.08-106302 · Cited by 191 · see citing works
Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T., & Yoneda, T. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-06-0356 · Cited by 187 · see citing works
Schnurri-2 Controls BMP-Dependent Adipogenesis via Interaction with Smad Proteins
Jin, W., Takagi, T., Kanesashi, S.-N., Kurahashi, T., Nomura, T., Harada, J., & Ishii, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.016 · Cited by 170 · see citing works
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
Iwayama, T., Steele, C., Yao, L., Dozmorov, M. G., Karamichos, D., Wren, J. D., & Olson, L. E. (2015) · Genes & Development · doi:10.1101/gad.260554.115 · Cited by 164 · see citing works
Skin Punch Biopsy Explant Culture for Derivation of Primary Human Fibroblasts
Vangipuram, M., Ting, D., Kim, S., Diaz, R. L., & Schüle, B. (2013) · Journal of Visualized Experiments · doi:10.3791/3779 · Cited by 163 · see citing works
Sottile, V., & Seuwen, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01655-0 · Cited by 160 · see citing works
WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4
Hammarstedt, A., Hedjazifar, S., Jenndahl, L. E., Gogg, S., Grünberg, J. R., Gustafson, B., Klimčáková, E., Štich, V., Langin, D., Laakso, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1211255110 · Cited by 155 · see citing works
The EGF-like Protein dlk1 Inhibits Notch Signaling and Potentiates Adipogenesis of Mesenchymal Cells
Nueda, M., Baladrón, V., Sánchez‐Solana, B., et al. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.043 · Cited by 153 · see citing works
Kanazawa, A., Tsukada, S., Kamiyama, M., Yanagimoto, T., Nakajima, M., & Maeda, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.007 · Cited by 148 · see citing works
Histone Deacetylase 9 Is a Negative Regulator of Adipogenic Differentiation
Chatterjee, T. K., Idelman, G., Blanco, V., Blomkalns, A. L., Piegore, M., Weintraub, D. S., Kumar, S., Rajsheker, S., Manka, D. R., Rudich, S. M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.262964 · Cited by 147 · see citing works
Regeneration of hair follicles and sebaceous glands from the epithelium of scars in the rabbit.
Breedis, C. (1954) · PubMed · Cited by 142 · see citing works
Restricted Adipogenesis in Hypertrophic Obesity
Gustafson, B., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2013) · Diabetes · doi:10.2337/db13-0473 · Cited by 139 · see citing works
FOXKs Promote Wnt/β-Catenin Signaling by Translocating DVL into the Nucleus
Wang, W., Li, X., Lee, M., Jun, S., Aziz, K. E., Feng, L., Tran, M. K., Li, N., McCrea, P. D., Park, J., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.031 · Cited by 136 · see citing works
Runx1/AML1/Cbfa2 Mediates Onset of Mesenchymal Cell Differentiation Toward Chondrogenesis
Wang, Y., Belflower, R., Dong, Y., Schwarz, E. M., O’Keefe, R. J., & Drissi, H. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050516 · Cited by 134 · see citing works
Regulation of Early Adipose Commitment by Zfp521
Kang, S., Åkerblad, P., Kiviranta, R., Gupta, R. K., Kajimura, S., Griffin, M. J., Min, J., Baron, R., & Rosen, E. D. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001433 · Cited by 130 · see citing works
Self-citationD, H. S. M., Rennert, R. C., Rodrigues, M., Sorkin, M., Glotzbach, J. P., Januszyk, M., 藤原敏宏, Longaker, M. T., & Gurtner, G. C. (2014) · Stem Cells · doi:10.1002/stem.1648 · Cited by 112 · see citing works
Özhan, G., Sezgin, E., Wehner, D., Pfister, A. S., Kühl, S. J., Kagermeier-Schenk, B., Kühl, M., Schwille, P., & Weidinger, G. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.07.020 · Cited by 112 · see citing works
Park, J. ‐., Jung, J. ‐., Lee, Y. ‐., & Kang, K. (2008) · Cell Proliferation · doi:10.1111/j.1365-2184.2008.00565.x · Cited by 108 · see citing works
Wnt4 and Wnt5a promote adipocyte differentiation
Nishizuka, M., Koyanagi, A., Osada, S., & Imagawa, M. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.08.011 · Cited by 106 · see citing works
Wnt/β-Catenin Signaling Stimulates Chondrogenic and Inhibits Adipogenic Differentiation of Pericytes
Kirton, J. P., Crofts, N. J., George, S. J., Brennan, K. R., & Canfield, A. E. (2007) · Circulation Research · doi:10.1161/circresaha.107.156372 · Cited by 106 · see citing works
van Tienen, F. H. J., Laeremans, H., Kallen, C., & Smeets, H. J. M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.004 · Cited by 104 · see citing works
Chatterjee, T. K., Basford, J. E., Knoll, E., Tong, W. S., Blanco, V., Blomkalns, A. L., Rudich, S. M., Lentsch, A. B., Hui, D. Y., & Weintraub, N. L. (2013) · Diabetes · doi:10.2337/db13-1148 · Cited by 104 · see citing works
Gentile, T. L., Lü, C., Lodato, P. M., Tse, S., Olejniczak, S. H., Witze, E. S., Thompson, C. B., & Wellen, K. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01495-12 · Cited by 102 · see citing works
Mastrogiannaki, M., Lichtenberger, B. M., Reimer, A. S., Collins, C. A., Driskell, R. R., & Watt, F. M. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.01.036 · Cited by 98 · see citing works
Low Circulating IGF-II Concentrations Predict Weight Gain and Obesity in Humans
Sandhu, M. S., Gibson, M., Heald, A. H., Dunger, D. B., & Wareham, N. J. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1403 · Cited by 96 · see citing works
Mitterberger, M. C., Lechner, S. G., Mattesich, M., Kaiser, A. M., Probst, D., Wenger, N., Pierer, G., & Zwerschke, W. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.04.001 · Cited by 95 · see citing works
Skin Punch Biopsy Explant Culture for Derivation of Primary Human Fibroblasts
Vangipuram, M., Ting, D., Kim, S., et al. (2013) · Journal of Visualized Experiments · doi:10.3791/3779-v · Cited by 95 · see citing works
Addison, W. N., Fu, M. M.-J., Yang, H. X., Zhao, L., Nagano, K., Gori, F., & Baron, R. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00185-14 · Cited by 92 · see citing works
Incomplete Wound Contracture and the Phenomenon of Hair Neogenesis in Rabbits' Skin
Billingham, R. E., & Russell, P. S. (1956) · Nature · doi:10.1038/177791b0 · Cited by 86 · see citing works
Jones, B. K. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.8.807 · Cited by 81 · see citing works
Alcaraz, W. A., Gold, D. A., Raponi, É., Gent, P. M., Concepcion, D., & Hamilton, B. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609184103 · Cited by 79 · see citing works
Self-citationGrünberg, J. R., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.511964 · Cited by 79 · see citing works
PPARγ Ligand-Dependent Induction of STAT1, STAT5A, and STAT5B during Adipogenesis
Stephens, J. M., Morrison, R. F., Wu, Z., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0889 · Cited by 75 · see citing works
Gadi, J., Jung, S., Lee, M.-J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.413377 · Cited by 66 · see citing works
Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts
Günther, T., Poli, C., Müller, J. M., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600773 · Cited by 64 · see citing works
Mortensen, S. B., Jensen, C. H., Schneider, M., Thomassen, M., Kruse, T. A., Laborda, J., Sheikh, S. P., & Andersen, D. C. (2012) · Diabetes · doi:10.2337/db12-0176 · Cited by 62 · see citing works
Wang, X., Hsi, T., Guerrero‐Juarez, C. F., Pham, K., Cho, K., McCusker, C., Monuki, E. S., Cho, K. W. Y., Gay, D. L., & Plikus, M. V. (2015) · Regeneration · doi:10.1002/reg2.38 · Cited by 59 · see citing works
Self-citationChen, Y.-H., Yeh, F.-L., Yeh, S., Ma, H.-T., Hung, S., Hung, M., & Li, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199612 · Cited by 59 · see citing works
The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity
Landsberg, R. L., Sero, J., Danielian, P. S., Yuan, T. L., Lee, E. Y., & Lees, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0138064100 · Cited by 57 · see citing works
Agouti regulates adipocyte transcription factors
Mynatt, R. L., & Stephens, J. M. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.4.c954 · Cited by 52 · see citing works
Amini‐Nik, S., Glancy, D., Boimer, C., Whetstone, H., Keller, C., & Alman, B. A. (2011) · Stem Cells · doi:10.1002/stem.688 · Cited by 48 · see citing works
Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation
Karbiener, M., Glantschnig, C., Pisani, D. F., Laurencikiene, J., Dahlman, I. A., Herzig, S., Amri, E., & Scheideler, M. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.121 · Cited by 46 · see citing works
FGF-10 Is a Growth Factor for Preadipocytes in White Adipose Tissue
Yamasaki, M., Emoto, H., Konishi, M., Mikami, T., Ohuchi, H., Nakao, K., & Itoh, N. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0594 · Cited by 46 · see citing works
Epigenetic control of skin and hair regeneration after wounding
Plikus, M. V., Guerrero‐Juarez, C. F., Treffeisen, E. R., & Gay, D. L. (2014) · Experimental Dermatology · doi:10.1111/exd.12488 · Cited by 45 · see citing works
Self-citationSuv39h1 Mediates AP-2α-Dependent Inhibition of C/EBPα Expression during Adipogenesis
Zhang, Z.-C., Liu, Y., Li, S.-F., Guo, L., Zhao, Y., Qian, S.-W., Wen, B., Tang, Q.-Q., & Li, X. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00070-14 · Cited by 43 · see citing works
Peláez‐García, A., Barderas, R., Batlle, R., Viñas-Castells, R., Bartolomé, R. A., Torres, S., Mendes, M. L., López-Lucendo, M. F., Mazzolini, R., Bonilla, F., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.045328 · Cited by 43 · see citing works
Beak, J. Y., Kang, H. S., Kim, Y. S., & Jetten, A. M. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070503 · Cited by 39 · see citing works
Chatterjee, T. K., Basford, J. E., Yiew, K. H., Stepp, D. W., Hui, D. Y., & Weintraub, N. L. (2014) · Adipocyte · doi:10.4161/adip.28814 · Cited by 39 · see citing works
Role of Fgf10 in cell proliferation in white adipose tissue
Konishi, M., Asaki, T., Koike, N., et al. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.01.010 · Cited by 37 · see citing works
c-Jun regulates adipocyte differentiation via the KLF15-mediated mode
Lee, D. S., Choi, H., Han, B., Kim, W. K., Lee, S. C., Oh, K., & Bae, K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.035 · Cited by 37 · see citing works
Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo
Asaki, T., Konishi, M., Miyake, A., Kato, S., Tomizawa, M., & Itoh, N. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.12.017 · Cited by 34 · see citing works
Kaushal, G., Rognoni, E., Lichtenberger, B. M., Driskell, R. R., Kretzschmar, K., Hoste, E., & Watt, F. M. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.319 · Cited by 33 · see citing works
Brun, J., Fromigué, O., Dieudonné, F., Marty, C., Chen, J., Dahan, J., Yu, W., & Marie, P. J. (2012) · Bone · doi:10.1016/j.bone.2012.11.020 · Cited by 33 · see citing works
Borensztein, M., Viengchareun, S., Montarras, D., Journot, L., Binart, N., Lombès, M., & Dandolo, L. (2012) · The FASEB Journal · doi:10.1096/fj.12-208496 · Cited by 33 · see citing works
Constitutively active Stat5A and Stat5B promote adipogenesis
Wakao, H., Wakao, R., Oda, A., & Fujita, H. (2010) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-010-0193-7 · Cited by 32 · see citing works
CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes
Ma, X., Zhang, H., Yuan, L., Jing, H., Thacker, P. A., & Li, D. (2011) · Biochemical Journal · doi:10.1042/bj20101475 · Cited by 31 · see citing works
A cellular, molecular, and pharmacological basis for appendage regeneration in micePreprint
Leung, T., Snyder, E. R., Liu, Y., Wang, J., & Kim, S. K. (2015) · Genes & Development · doi:10.1101/gad.267724.115 · Cited by 31 · see citing works
Gao, P., Zhang, Y., Liu, Y., Chen, J., Zong, C., Cong, Y., Cui, S., Gao, W., Qin, D., Sun, W., et al. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.09.010 · Cited by 30 · see citing works
Self-citationWojciechowicz, K., Markiewicz, E., & Jahoda, C. A. B. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00689.x · Cited by 29 · see citing works
Ishibashi, J., Karagonlar, Z. F., Rajakumari, S., Wood, K. H., Conroe, H. M., Steger, D. J., & Seale, P. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06529-11 · Cited by 23 · see citing works
Self-citationRegulation of PPARγ and Obesity by Agouti/Melanocortin Signaling in Adipocytes
Mynatt, R. L., & Stephens, J. M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03173.x · Cited by 21 · see citing works
miR‐195a Inhibits Adipocyte Differentiation by Targeting the Preadipogenic Determinator Zfp423
Yun, U. J., Song, N., Yang, D. K., Kwon, S., Kim, K., Kim, S., Jo, D., Park, W. J., Park, K. W., & Kang, H. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25204 · Cited by 19 · see citing works
Lee, Y., Hsu, T., Chiu, W.-C., Sarkozy, H., Kulber, D. A., Choi, A. W., Kim, E. W., Benya, P. D., & Tuan, T. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12397 · Cited by 18 · see citing works
Self-citationSaito, T., Ohba, S., Yano, F., et al. (2015) · Cellular Reprogramming · doi:10.1089/cell.2014.0059 · Cited by 10 · see citing works
Wang, Y., Li, X., Liu, Z.-Y., Zhang, T.-G., Chen, B., Hou, G., Hong, Q., Xie, P., & Du, S. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.06.220 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Adipogenesis and metabolic health
Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works
Ellis, S., Lin, E. J., & Tartar, D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0234-9 · Cited by 625 · see citing works
Hu, Y., Rao, S.-S., Wang, Z.-X., Cao, J., Tan, Y.-J., Luo, J., Li, H.-M., Zhang, W.-S., Chen, C.-Y., & Xie, H. (2018) · Theranostics · doi:10.7150/thno.21234 · Cited by 574 · see citing works
Guerrero-Juarez, C. F., Dedhia, P. H., Jin, S., Ruiz-Vega, R., Ma, D., Liu, Y., Yamaga, K., Shestova, O., Gay, D. L., Yang, Z., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08247-x · Cited by 521 · see citing works
Self-citationMyofibroblast proliferation and heterogeneity are supported by macrophages during skin repair
Shook, B. A., Wasko, R. R., Rivera-Gonzalez, G. C., Salazar-Gatzimas, E., López-Giráldez, F., Dash, B. C., Muñoz-Rojas, A. R., Aultman, K. D., Zwick, R. K., Lei, V., et al. (2018) · Science · doi:10.1126/science.aar2971 · Cited by 519 · see citing works
Obesity and the risk of cardiometabolic diseases
Valenzuela, P. L., Carrera-Bastos, P., Castillo-García, A., Lieberman, D. E., Santos-Lozano, A., & Lucia, A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00847-5 · Cited by 452 · see citing works
Mesenchymal stem cells in fibrotic disease
El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.011 · Cited by 430 · see citing works
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication
Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396 · see citing works
Patch repair of deep wounds by mobilized fascia
Correa-Gallegos, D., Jiang, D., Christ, S., Ramesh, P., Ye, H., Wannemacher, J., Kalgudde Gopal, S., Yu, Q., Aichler, M., Walch, A., et al. (2019) · Nature · doi:10.1038/s41586-019-1794-y · Cited by 247 · see citing works
Estrogen Effects on Wound Healing
Horng, H.-C., Chang, W.-H., Yeh, C.-C., Huang, B.-S., Chang, C.-P., Chen, Y.-J., Tsui, K.-H., & Wang, P.-H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112325 · Cited by 208 · see citing works
Mechanical regulation of myofibroblast phenoconversion and collagen contraction
Hinz, B., McCulloch, C. A., & Coelho, N. M. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.027 · Cited by 182 · see citing works
Multipotent stromal cells: One name, multiple identities
Soliman, H., Theret, M., Scott, W., Hill, L., Underhill, T. M., Hinz, B., & Rossi, F. M. V. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.001 · Cited by 147 · see citing works
- Authors
- Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., Oh, J. W., Wang, X., Ramirez, A., Konopelski, S. E., Elzein, A., Wang, A., Supapannachart, R. J., Lee, H.-L., Lim, C. H., Nace, A., Guo, A., Treffeisen, E., Andl, T., Ramirez, R. N., Murad, R., Offermanns, S., Metzger, D., Chambon, P., Widgerow, A. D., Tuan, T.-L., Mortazavi, A., Gupta, R. K., Hamilton, B. A., Millar, S. E., Seale, P., Pear, W. S., Lazar, M. A., & Cotsarelis, G.
- Affiliations
- University of California, Irvine (US)
- Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, Irvine, CA 92697, USA.
- New York University (US)
- University of Pennsylvania (US)
- The University of Texas Southwestern Medical Center (US)
- Inserm (FR)
- University of Central Florida (US)
- Max Planck Institute for Heart and Lung Research (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Southern California (US)
- University of California San Diego (US)
- Corresponding author
- Plikus, Maksim V.
- Cotsarelis, George
- ORCID
- Plikus, Maksim V.
- Guerrero-Juarez, Christian F.
- Ito, Mayumi
- Li, Yun Rose
- Dedhia, Priya H.
- Zheng, Ying
- Shao, Mengle
- Gay, Denise L.
- Hsi, Tsai-Ching
- Oh, Ji Won
- Wang, Xiaojie
- Ramirez, Amanda
- Konopelski, Sara E.
- Elzein, Arijh
- Wang, Anne
- Lim, Chae Ho
- Nace, Arben
- Guo, Amy
- Treffeisen, Elsa
- Andl, Thomas
- Ramirez, Ricardo N.
- Murad, Rabi
- Offermanns, Stefan
- Metzger, Daniel
- Chambon, Pierre
- Widgerow, Alan D.
- Tuan, Tai-Lan
- Mortazavi, Ali
- Gupta, Rana K.
- Hamilton, Bruce A.
- Millar, Sarah E.
- Seale, Patrick
- Pear, Warren S.
- Lazar, Mitchell A.
- Cotsarelis, George
- Venue
- Science
- Published
- 2017-02-17
- Volume
- 355
- Issue
- 6326
- Pages
- 748-752
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5464786
- OpenAlex
- W2568092366
- Cited by
- 584
- References
- 110
- Citations by year
- 2026: 47 · 2025: 58 · 2024: 53 · 2023: 73 · 2022: 74 · 2021: 66 · 2020: 69 · 2019: 54 · 2018: 60 · 2017: 28
- FWCI
- 54.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Journal of International Crisis and Risk Communication Research (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Science Foundation (award295757, DGE-1321846)
- National Cancer Institute (award295758, T32-CA009054)
- National Institute of General Medical Sciences (award295759, R01-GM095821,R25-GM055246)
- National Institute of Diabetes and Digestive and Kidney Diseases (award295760, P30-DK019525,P01-DK049210)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (award295761, R01-AR055309,P30-AR057217,R01-AR067273,R01-AR069653)
- Pew Charitable Trusts (award295762)
- California Institute for Regenerative Medicine (award295763, TG2-01152)
- Dermatology Foundation (award295764)
- Canadian Institutes of Health Research (award295765, MFE-123724)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- scar formation, wound healing, hair follicle, myofibroblasts, adipogenesis, adipose tissue regeneration, BMP signaling, dermal cells
- MeSH terms
- Animals, Cells, Cultured, Cicatrix, DNA-Binding Proteins, Fibroblasts, Humans, Mice, Inbred C57BL, Recombinant Proteins, Regeneration, Transcription Factors, Wound Healing, Signal Transduction, Adipocytes, Hair Follicle, Bone Morphogenetic Proteins, Mice, Bone Morphogenetic Protein 2, Bone Morphogenetic Protein 4, Myofibroblasts, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review