The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The Balance of Th17 versus Treg Cells in Autoimmunity
Open accessAbstract
T helper type 17 (Th17) cells and pTreg cells, which share a common precursor cell (the naïve CD4 T cell), require a common tumor growth factor (TGF)-β signal for initial differentiation. However, terminally differentiated cells fulfill opposite functions: Th17 cells cause autoimmunity and inflammation, whereas Treg cells inhibit these phenomena and maintain immune homeostasis. Thus, unraveling the mechanisms that affect the Th17/Treg cell balance is critical if we are to better understand autoimmunity and tolerance. Recent studies have identified many factors that influence this balance; these factors range from signaling pathways triggered by T cell receptors, costimulatory receptors, and cytokines, to various metabolic pathways and the intestinal microbiota. This review article summarizes recent advances in our understanding of the Th17/Treg balance and its implications with respect to autoimmune disease.
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Cites
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Kölliker-Frers, R., Udovin, L., Otero-Losada, M., Kobiec, T., Herrera, M. I., Palacios, J., Razzitte, G., & Capani, F. (2021) · Mediators of Inflammation · doi:10.1155/2021/9999146 · Cited by 258
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Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02104-8 · Cited by 133
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease
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Metadata
- Authors
- Lee, G. R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-03-03
- Volume
- 19
- Issue
- 3
- Pages
- 730
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2791371888
- Cited by
- 857
- References
- 31
- FWCI
- 20.93
- Type
- journal article
- Language
- en
- Open access
- gold
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