Cited by 134Liver physiology and pathologyTissue Engineering and Regenerative MedicineOrgan Transplantation Techniques and Outcomes

Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics

Open access
Ma, Xiao, Huang, Tengda, Chen, Xiangzheng, Li, Qian, Liao, Mingheng, Fu, Li, Huang, Jiwei, Yuan, Kefei +2 more·2025·Signal Transduction and Targeted Therapy

Abstract

Liver repair and regeneration are crucial physiological responses to hepatic injury and are orchestrated through intricate cellular and molecular networks. This review systematically delineates advancements in the field, emphasizing the essential roles played by diverse liver cell types. Their coordinated actions, supported by complex crosstalk within the liver microenvironment, are pivotal to enhancing regenerative outcomes. Recent molecular investigations have elucidated key signaling pathways involved in liver injury and regeneration. Viewed through the lens of metabolic reprogramming, these pathways highlight how shifts in glucose, lipid, and amino acid metabolism support the cellular functions essential for liver repair and regeneration. An analysis of regenerative variability across pathological states reveals how disease conditions influence these dynamics, guiding the development of novel therapeutic strategies and advanced techniques to enhance liver repair and regeneration. Bridging laboratory findings with practical applications, recent clinical trials highlight the potential of optimizing liver regeneration strategies. These trials offer valuable insights into the effectiveness of novel therapies and underscore significant progress in translational research. In conclusion, this review intricately links molecular insights to therapeutic frontiers, systematically charting the trajectory from fundamental physiological mechanisms to innovative clinical applications in liver repair and regeneration.

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  1. [410]Sundaresan, M. et al. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270, 296–299 (1995). 7569979

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Authors
Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y.
Affiliations
Sichuan University (CN)
Corresponding author
  • Wang, Zhen
  • Zeng, Yong
Venue
Signal Transduction and Targeted Therapy
Published
2025-02-08
Volume
10
Issue
1
Pages
63-63
ISSN
2059-3635 (ISSN-L)
OpenAlex
W4407274978
Cited by
133
References
832
Citations by year
2026: 83 · 2025: 50
FWCI
19.43
Type
journal article
Language
en
Open access
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (ZYJC18008, 82270643, 82170,621, 82070644)
  • Sichuan University (ZYJC18008)
  • West China Hospital, Sichuan University (ZYJC18008, ZYGD22006, 1.3.5)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
liver regeneration, liver repair, liver injury, liver microenvironment, cell-cell crosstalk, signaling pathways, metabolic reprogramming, glucose metabolism, lipid metabolism, amino acid metabolism, clinical trials
MeSH terms
Animals, Humans, Liver, Liver Diseases, Liver Regeneration, Signal Transduction

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