Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
Open accessAbstract
Liver repair and regeneration are crucial physiological responses to hepatic injury and are orchestrated through intricate cellular and molecular networks. This review systematically delineates advancements in the field, emphasizing the essential roles played by diverse liver cell types. Their coordinated actions, supported by complex crosstalk within the liver microenvironment, are pivotal to enhancing regenerative outcomes. Recent molecular investigations have elucidated key signaling pathways involved in liver injury and regeneration. Viewed through the lens of metabolic reprogramming, these pathways highlight how shifts in glucose, lipid, and amino acid metabolism support the cellular functions essential for liver repair and regeneration. An analysis of regenerative variability across pathological states reveals how disease conditions influence these dynamics, guiding the development of novel therapeutic strategies and advanced techniques to enhance liver repair and regeneration. Bridging laboratory findings with practical applications, recent clinical trials highlight the potential of optimizing liver regeneration strategies. These trials offer valuable insights into the effectiveness of novel therapies and underscore significant progress in translational research. In conclusion, this review intricately links molecular insights to therapeutic frontiers, systematically charting the trajectory from fundamental physiological mechanisms to innovative clinical applications in liver repair and regeneration.
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Transient hypoglycemia, hepatic steatosis, and BA overload occur after PHx.
“Consistent with prior reports of transient hypoglycemia,34,35 hepatic steatosis,34,53 and BA overload4,34 occurring after PHx”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [34]
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- Authors
- Ma, X., Huang, T., Chen, X., Li, Q., Liao, M., Fu, L., Huang, J., Yuan, K., Wang, Z., & Zeng, Y.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Wang, Zhen
- Zeng, Yong
- Venue
- Signal Transduction and Targeted Therapy
- Published
- 2025-02-08
- Volume
- 10
- Issue
- 1
- Pages
- 63-63
- ISSN
- 2059-3635 (ISSN-L)
- PMC
- PMC11806117
- OpenAlex
- W4407274978
- Cited by
- 133
- References
- 832
- Citations by year
- 2026: 83 · 2025: 50
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (ZYJC18008, 82270643, 82170,621, 82070644)
- Sichuan University (ZYJC18008)
- West China Hospital, Sichuan University (ZYJC18008, ZYGD22006, 1.3.5)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- liver regeneration, liver repair, liver injury, liver microenvironment, cell-cell crosstalk, signaling pathways, metabolic reprogramming, glucose metabolism, lipid metabolism, amino acid metabolism, clinical trials
- MeSH terms
- Animals, Humans, Liver, Liver Diseases, Liver Regeneration, Signal Transduction
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