The DOI matches its Crossref record; 215 of the 217 references it cites were found in a registry or an index.
Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
Open accessAbstract
Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer’s disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures. Brains of patients with AD, LBD, FTD and PSP show hyperphosphorylated tau aggregates, amyloid-β plaques and neuropil threads. Increasing evidence suggests the existence of overlapping mechanisms related to the generation of network hyperexcitability and cognitive decline. Neuronal overexpression of tau with various mutations found in FTD with parkinsonism-linked to chromosome 17 (FTDP-17) in mice produces epileptic activity. On the other hand, the use of certain antiepileptic drugs in animal models with AD prevents cognitive impairment. Further efforts should be made to search for plausible common targets for both conditions. Moreover, attempts should also be made to evaluate the use of drugs targeting tau and amyloid-β as suitable pharmacological interventions in epileptic disorders. The diagnosis of dementia and epilepsy in early stages of those diseases may be helpful for the initiation of treatments that could prevent the generation of epileptic activity and cognitive deterioration.
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“However, the possibility of seizures and hyperexcitability in primary tauopathies should not be ruled out, as they occur more frequently in these diseases than in the general population (Beagle et al., 2017; Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
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“Given that neurodegenerative conditions characterized by hyperphosphorylated tau aggregations exhibit increased rates of epilepsy, epilepsies are being re-conceptualized within a tauopathy context (Xi et al., 2011; Sanchez et al., 2018; Ali et al., 2019).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
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“Furthermore, tau pathology is repeatedly found in human epilepsy (Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
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“While individuals with dementia have higher rates of epilepsy, seizures are experienced more frequently in tauopathy-associated dementias like AD than in other dementias (Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
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“seizures are experienced more frequently in tauopathy-associated dementias like AD than in other dementias (Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
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Items 201–215 of 215
Epilepsy at the prodromal stages of neurodegenerative diseases
Cretin, B., Philippi, N., Bitonto, L. D., & Blanc, F. (2017) · Gériatrie et Psychologie Neuropsychiatrie du Viellissement · doi:10.1684/pnv.2017.0652 · Cited by 20
Dysregulation of PINCH signaling in mesial temporal epilepsy
Liu, C. Y., Russin, J., Heck, C. N., Kawata, K., Adiga, R., Yen, W., Lambert, J. P., Stear, B. J., Law, M., Marquez, Y. D., et al. (2016) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2016.10.012 · Cited by 19
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Park2-Null/Tau Transgenic Mice Reveal a Functional Relationship between Parkin and Tau
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Self-citationCase 1, 1994: Rapidly progressive aphasia, apraxia, dementia, myoclonus, and parkinsonism
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Familial Progressive Supranuclear Palsy: A Literature Review
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Self-citationEpileptic seizure presenting as dementia with Lewy bodies
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GSK3β and tau protein in Alzheimer's disease and epilepsy
Toral-Rios, D., Pichardo-Rojas, P. S., Alonso-Vanegas, M., & Campos-Peña, V. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00019 · Cited by 158
Kazim, S. F., Seo, J. H., Bianchi, R., Larson, C. S., Sharma, A., Wong, R. K. S., Gorbachev, K., & Pereira, A. C. (2021) · eNeuro · doi:10.1523/eneuro.0418-20.2020 · Cited by 120
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Bi-directional association between epilepsy and dementia
Stefanidou, M., Beiser, A., Himali, J. J., Peng, T. J., Devinsky, O., Seshadri, S. S., & Friedman, D. J. (2020) · Neurology · doi:10.1212/wnl.0000000000011077 · Cited by 94
Metadata
- Authors
- Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J.
- Affiliations
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Laboratory of Neurology, IIS (Instituto Investigación Sanitaria/Health Research Institute)-Jiménez Díaz Foundation, UAM (Universidad Autonoma de Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain
- Corresponding author
- Sánchez, Marina
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-04-05
- Volume
- 19
- Issue
- 4
- Pages
- 1092
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5979593
- OpenAlex
- W2795704013
- Cited by
- 68
- References
- 217
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Carlos III Institute of Health (PI13/00865)
- Biomedical Research Network Center on Rare Diseases, CIBERER
- NINDS, NIH (P01NS097197)
- Spanish Ministry of Economy (SAF2014-59594-R)
- Conchita Rábago Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- tau pathology, epilepsy, dementia, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, progressive supranuclear palsy, MAPT mutations, amyloid plaques, neuropil threads, network hyperexcitability, cognitive decline, FTDP-17, antiepileptic drugs, animal models, early diagnosis
- MeSH terms
- Animals, Brain, Dementia, Epilepsy, Humans, tau Proteins
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