Cited by 68Alzheimer's disease research and treatmentsEpilepsy research and treatmentDementia and Cognitive Impairment Research

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Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.

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Sánchez, Marina, García-Cabrero, Ana, Sánchez-Elexpuru, Gentzane, Burgos, Daniel, Serratosa, José·2018·International Journal of Molecular Sciences

DOI 10.3390/ijms19041092PMC PMC5979593

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Abstract

Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer’s disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures. Brains of patients with AD, LBD, FTD and PSP show hyperphosphorylated tau aggregates, amyloid-β plaques and neuropil threads. Increasing evidence suggests the existence of overlapping mechanisms related to the generation of network hyperexcitability and cognitive decline. Neuronal overexpression of tau with various mutations found in FTD with parkinsonism-linked to chromosome 17 (FTDP-17) in mice produces epileptic activity. On the other hand, the use of certain antiepileptic drugs in animal models with AD prevents cognitive impairment. Further efforts should be made to search for plausible common targets for both conditions. Moreover, attempts should also be made to evaluate the use of drugs targeting tau and amyloid-β as suitable pharmacological interventions in epileptic disorders. The diagnosis of dementia and epilepsy in early stages of those diseases may be helpful for the initiation of treatments that could prevent the generation of epileptic activity and cognitive deterioration.

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Authors: Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J.
Affiliations: Centre for Biomedical Network Research on Rare Diseases (ES)
Consejo Superior de Investigaciones Científicas (ES)
Laboratory of Neurology, IIS (Instituto Investigación Sanitaria/Health Research Institute)-Jiménez Díaz Foundation, UAM (Universidad Autonoma de Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain
Corresponding author: Sánchez, Marina
ORCID: Sánchez, Marina
García-Cabrero, Ana
Burgos, Daniel
Serratosa, José
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2018-04-05
Volume: 19
Issue: 4
Pages: 1092
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms19041092
PMC: PMC5979593
OpenAlex: W2795704013
Cited by: 68
References: 217
Citations by year: 2026: 8 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 3
FWCI: 1.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Carlos III Institute of Health (PI13/00865)
Biomedical Research Network Center on Rare Diseases, CIBERER
NINDS, NIH (P01NS097197)
Spanish Ministry of Economy (SAF2014-59594-R)
Conchita Rábago Foundation
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: tau pathology, epilepsy, dementia, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, progressive supranuclear palsy, MAPT mutations, amyloid plaques, neuropil threads, network hyperexcitability, cognitive decline, FTDP-17, antiepileptic drugs, animal models, early diagnosis
MeSH terms: Animals, Brain, Dementia, Epilepsy, Humans, tau Proteins

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Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.

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