The DOI matches its Crossref record; 215 of the 217 references it cites were found in a registry or an index.
Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
Open accessAbstract
Patients with dementia present epilepsy more frequently than the general population. Seizures are more common in patients with Alzheimer’s disease (AD), dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive supranuclear palsy (PSP) than in other dementias. Missense mutations in the microtubule associated protein tau (MAPT) gene have been found to cause familial FTD and PSP, while the P301S mutation in MAPT has been associated with early-onset fast progressive dementia and the presence of seizures. Brains of patients with AD, LBD, FTD and PSP show hyperphosphorylated tau aggregates, amyloid-β plaques and neuropil threads. Increasing evidence suggests the existence of overlapping mechanisms related to the generation of network hyperexcitability and cognitive decline. Neuronal overexpression of tau with various mutations found in FTD with parkinsonism-linked to chromosome 17 (FTDP-17) in mice produces epileptic activity. On the other hand, the use of certain antiepileptic drugs in animal models with AD prevents cognitive impairment. Further efforts should be made to search for plausible common targets for both conditions. Moreover, attempts should also be made to evaluate the use of drugs targeting tau and amyloid-β as suitable pharmacological interventions in epileptic disorders. The diagnosis of dementia and epilepsy in early stages of those diseases may be helpful for the initiation of treatments that could prevent the generation of epileptic activity and cognitive deterioration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“However, the possibility of seizures and hyperexcitability in primary tauopathies should not be ruled out, as they occur more frequently in these diseases than in the general population (Beagle et al., 2017; Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Given that neurodegenerative conditions characterized by hyperphosphorylated tau aggregations exhibit increased rates of epilepsy, epilepsies are being re-conceptualized within a tauopathy context (Xi et al., 2011; Sanchez et al., 2018; Ali et al., 2019).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, tau pathology is repeatedly found in human epilepsy (Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
The cited source says what the claim attributes to it.
In the citing paper
“While individuals with dementia have higher rates of epilepsy, seizures are experienced more frequently in tauopathy-associated dementias like AD than in other dementias (Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
The cited source says what the claim attributes to it.
In the citing paper
“seizures are experienced more frequently in tauopathy-associated dementias like AD than in other dementias (Sanchez et al., 2018).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Sanchez et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685
Grundke-Iqbal, I., Iqbal, K., Tung, Y. C., Quinlan, M., Wisniewski, H. M., & Binder, L. I. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4913 · Cited by 3,676
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498
Cited by
Sorted by citations
GSK3β and tau protein in Alzheimer's disease and epilepsy
Toral-Rios, D., Pichardo-Rojas, P. S., Alonso-Vanegas, M., & Campos-Peña, V. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00019 · Cited by 158
Kazim, S. F., Seo, J. H., Bianchi, R., Larson, C. S., Sharma, A., Wong, R. K. S., Gorbachev, K., & Pereira, A. C. (2021) · eNeuro · doi:10.1523/eneuro.0418-20.2020 · Cited by 120
Dewey, C. W., Davies, E. S., Xie, H., & Wakshlag, J. J. (2019) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2019.01.013 · Cited by 118
Ondrejčák, T., Klyubin, I. V., Corbett, G. T., Fraser, G. M., Hong, W., Mably, A. J., Gardener, M. J., Hammersley, J., Perkinton, M. S., Billinton, A., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1700-18.2018 · Cited by 110
Bi-directional association between epilepsy and dementia
Stefanidou, M., Beiser, A., Himali, J. J., Peng, T. J., Devinsky, O., Seshadri, S. S., & Friedman, D. J. (2020) · Neurology · doi:10.1212/wnl.0000000000011077 · Cited by 94
Dementia in late-onset epilepsy
Johnson, E. L., Krauss, G. L., Kucharska‐Newton, A., Albert, M., Brandt, J., Walker, K. A., Yaşar, S., Knopman, D. S., Vossel, K. A., & Gottesman, R. F. (2020) · Neurology · doi:10.1212/wnl.0000000000011080 · Cited by 89
Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer’s Disease Stages
Pasquini, L., Rahmani, F., Balajoo, S. M., Joie, R. L., Zarei, M., Sorg, C., Drzezga, A. E., & Tahmasian, M. (2019) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-190121 · Cited by 77
Neurodegenerative pathways as targets for acquired epilepsy therapy development
Casillas-Espinosa, P. M., Ali, I. Y., & O'Brien, T. J. (2020) · Epilepsia Open · doi:10.1002/epi4.12386 · Cited by 59
Tombini, M., Assenza, G., Ricci, L., Lanzone, J., Boscarino, M., Vico, C., Magliozzi, A., & Lazzaro, V. D. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200286 · Cited by 54
Interweaving epilepsy and neurodegeneration: Vitamin E as a treatment approach
Upaganlawar, A. B., Wankhede, N. L., Kale, M. B., Umare, M. D., Sehgal, A., Singh, S., Bhatia, S., Al-Harrasi, A., Najda, A., Nurzyńska-Wierdak, R., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112146 · Cited by 53
Recent Progress in the Development of New Antiepileptic Drugs with Novel Targets
Belete, T. M. (2023) · Annals of Neurosciences · doi:10.1177/09727531231185991 · Cited by 49
Soluble tau aggregates inhibit synaptic long-term depression and amyloid β-facilitated LTD in vivo
Ondrejčák, T., Hu, N., Qi, Y., Klyubin, I. V., Corbett, G. T., Fraser, G. M., Perkinton, M. S., Walsh, D. M., Billinton, A., & Rowan, M. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.03.022 · Cited by 47
Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer’s Disease
Paudel, Y. N., Angelopoulou, E., Jones, N. C., O'Brien, T. J., Kwan, P., Piperi, C., Othman, I., & Shaikh, M. F. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00460 · Cited by 42
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy.
Alyenbaawi, H., Kanyo, R., Locskai, L. F., Kamali-Jamil, R., DuVal, M. G., Bai, Q., Wille, H., Burton, E. A., & Allison, W. T. (2021) · eLife · doi:10.7554/elife.58744 · Cited by 40
Epilepsy in Neurodegenerative Dementias: A Clinical, Epidemiological, and EEG Study
Arnaldi, D., Donniaquio, A., Mattioli, P., Massa, F., Grazzini, M., Meli, R., Filippi, L., Grisanti, S. G., Famà, F., Terzaghi, M., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191315 · Cited by 39
Chronic Noise Exposure and Risk of Dementia: A Systematic Review and Dose-Response Meta-Analysis
Meng, L., Zhang, Y., Zhang, S., Jiang, F., Sha, L., Lan, Y., & Huang, L. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.832881 · Cited by 40
Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy
Casillas-Espinosa, P. M., Anderson, A., Harutyunyan, A., Li, C. N., Lee, J.-Y., Braine, E. L., Brady, R. D., Sun, M., Huang, C., Barlow, C. K., et al. (2023) · eLife · doi:10.7554/elife.78877 · Cited by 37
Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy
Gómez‐Murcia, V., Sandau, U. S., Ferry, B., Parrot, S., Laurent, C., Basquin, M., Buée, L., Boison, D., & Blum, D. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.06.004 · Cited by 36
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35
Reducing PDK1/Akt Activity: An Effective Therapeutic Target in the Treatment of Alzheimer’s Disease
Yang, S., Du, Y., Zhao, X., Wu, C., & Yu, P. (2022) · Cells · doi:10.3390/cells11111735 · Cited by 38
Epileptic seizures in autosomal dominant forms of Alzheimer’s disease
Cortini, F., Cantoni, C., & Villa, C. (2018) · Seizure · doi:10.1016/j.seizure.2018.07.015 · Cited by 34
Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study
Toscano, E. C. D. B., Vieira, É. L. M., Grinberg, L. T., Rocha, N. P., Brant, J. A. S., Paradela, R. S., Giannetti, A. V., Suemoto, C. K., Leite, R. E. P., Nitríni, R., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03190-x · Cited by 33
Martin, S. P., & Leeman-Markowski, B. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2023.1287545 · Cited by 30
Alcantara‐Gonzalez, D., Chartampila, E., Criscuolo, C., & Scharfman, H. E. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105274 · Cited by 25
The Pathogenesis of Nodding Syndrome
Johnson, T. P., Sejvar, J. J., Nutman, T. B., & Nath, A. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032748 · Cited by 26
The role of parvalbumin interneuron dysfunction across neurodegenerative dementias
Smeralda, C. L., Pandit, S., Turrini, S., Reilly, J., Palmisano, A., Sprugnoli, G., Hampel, H. J., Benussi, A., Borroni, B., Press, D. Z., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102509 · Cited by 26
Kotloski, R. J., Dowding, J., Hermann, B. P., & Sutula, T. P. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00025-x · Cited by 23
Molecular Factors Mediating Neural Cell Plasticity Changes in Dementia Brain Diseases
Kozubski, W. P., Ong, K. T., Waleszczyk, W. J., Zabel, M. K., & Dorszewska, J. (2021) · Neural Plasticity · doi:10.1155/2021/8834645 · Cited by 21
Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction
Siano, G., Falcicchia, C., Origlia, N., Cattaneo, A., & Primio, C. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810145 · Cited by 22
Kalyvas, A.-C., Dimitriou, M., Ioannidis, P., Grigoriadis, N., & Afrantou, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133879 · Cited by 20
Gao, Y., Zheng, J., Jiang, T., Pi, G., Sun, F., Xiong, R., Wang, W., Wu, D., Li, S., Lei, H., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.633725 · Cited by 18
Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia
Shabir, O., Moll, T., Matuszyk, M. M., Eyre, B., Dake, M. D., Berwick, J., & Francis, S. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111361 · Cited by 17
Diagnosis and Management of Seizures in Neurodegenerative Diseases
Adan, G., Mitchell, J., Ziso, B., & Larner, A. J. (2021) · Current Treatment Options in Neurology · doi:10.1007/s11940-020-00656-y · Cited by 15
Localized proteomic differences in the choroid plexus of Alzheimer's disease and epilepsy patients
Leitner, D., Kanshin, E., Faustin, A., Thierry, M., Friedman, D. J., Devore, S., Ueberheide, B. M., Devinsky, O., & Wısnıewskı, T. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1221775 · Cited by 17
Alves, S. S., da Silva-Júnior, R. M. P., Delfino-Pereira, P., Pereira, M. G. A. G., Vasconcelos, I. C., Schwaemmle, H., Mazzei, R. F., Carlos, M. L., Espreáfico, E. M., Tedesco, A. C., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02810-w · Cited by 14
Meta-analysis of the risk of dementia in elderly patients with late-onset epilepsy
Tang, T. S., Zhang, R., & Pan, X. (2022) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2022.107499 · Cited by 14
Tan, Z., Wang, F., Wu, W.-P., Yu, L.-Z.-X., Wu, J., & Wang, L. (2024) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2024.109723 · Cited by 12
Xu, L., & Wang, Q. (2023) · Brain and Behavior · doi:10.1002/brb3.3221 · Cited by 12
UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model
Wen, Y., Wu, Q., Shi, Q., Xie, Y., Dān, W., Chen, Y., & Ma, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.154 · Cited by 13
Dahal, A., Karthivashan, G., & Kar, S. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.02.010 · Cited by 12
Vivash, L. E., Johns, H. T., Churilov, L. P., MacPhail, S., Casillas-Espinosa, P. M., Malpas, C. B., Shultz, S. R., Tailby, C., Wijayath, M., Reutens, D. C., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-075888 · Cited by 9
Hyperphosphorylated Tau and Cognition in Epilepsy
Witt, J., Andernach, J., Becker, A. J., & Helmstaedter, C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020514 · Cited by 9
Gene Expression of Disease-related Genes in Alzheimer’s Disease is Impaired by Tau Aggregation
Siano, G., Varisco, M., Scarlatti, A., Caiazza, M. C., Dunville, K., Cremisi, F., Costa, M., Pancrazi, L., Primio, C. D., & Cattaneo, A. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.10.009 · Cited by 9
Itsuno, M., Tanabe, H., Sano, E., Sasaki, T., Oyama, C., Bannai, H., Saito, K., Nakata, K., Endoh‐Yamagami, S., Okano, H., et al. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.12.009 · Cited by 7
Epilepsy and Neurodegeneration: A Bidirectional Relationship
Szaflarski, J. P. (2021) · Epiliepsy currents/Epilepsy currents · doi:10.1177/1535759721989668 · Cited by 6
Seizures and Epilepsy in Dementia: Diagnosis and Management
Ritter, L. M., & Nilsson, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-77904-7_12 · Cited by 4
Scharfman, H. E., Kam, K., Duffy, Á., LaFrancois, J. J., Leary, P., Chartampila, E., Ginsberg, S. D., & Lisgaras, C. P. (2025) · Frontiers in Dementia · doi:10.3389/frdem.2025.1513144 · Cited by 2
Tau pathology in epilepsy: emerging mechanisms and translational opportunities
Sen, A., Tai, X. Y., Galanopoulou, A. S., Thom, M., Aronica, E., Vivash, L. E., Hardmeier, M., Amos, A., Rüegg, S. J., Koepp, M. J., et al. (2026) · Brain · doi:10.1093/brain/awag108 · Cited by 2
Emerging Approaches for Regenerative Rehabilitation Following Traumatic Brain Injury
O’Donnell, J. C., Swanson, R. L., Wofford, K. L., Grovola, M. R., Purvis, E. M., Petrov, D., & Cullen, D. K. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-95884-8_13 · Cited by 2
Co-morbid seizures in frontotemporal dementia: What do they tell us?
Hashmi, S. A., Quigg, M., D’Abreu, A., Manning, C. A., Kapur, J., & Zawar, I. (2025) · Epilepsy Research · doi:10.1016/j.eplepsyres.2025.107640 · Cited by 1
From comorbidity to continuum: Alzheimer’s disease and epilepsy are connected-now what?
Alves, S. S., Manzine, P. R., dos Santos, F. M., Migliaccio, M. M., Alves, L. D. C., da Silva-Júnior, R. M. P., Becerra-Hernández, L. V., González-Acosta, C. A., Buriticá, E., Cominetti, M. R., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106682 · Cited by 1
Sleep–wake control with age and neurodegenerative diseases
Tang, W.-X., Yang, C., Zhang, M., Kushida, C. A., de Lecea, L., & Li, S. (2026) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2026.102352 · Cited by 1
Somogyi, A., & Wolf, E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721773 · Cited by 1
Ye, C., Zeng, P. H., Liu, Y.-C., Shi, Y., Liu, G., Wang, J., Zhou, X., & Tian, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-3294833/v1 · Cited by 1
Epilepsy and Neurodegeneration
Retinasamy, T., & Shaikh, M. F. (2023) · Springer eBooks · doi:10.1007/978-981-19-3949-5_23-1
Epilepsy and Neurodegeneration
Retinasamy, T., & Shaikh, M. F. (2024) · Springer eBooks · doi:10.1007/978-981-99-7557-0_23
Epilepsy of aging: an increasing challenge of the 21st century
Pejović, A. T., & Ristić, A. J. (2024) · Medicinski podmladak · doi:10.5937/mp75-51140
Epilepsy in alzheimer's disease: pathophysiological mechanisms and diagnostic features
Azhigova, A. M., Konovalova, T. I., & Vlasov, P. N. (2025) · Medical alphabet · doi:10.33667/2078-5631-2025-15-46-50
Sampei, K., Hirokawa, J., Kudo, T., Seki, C., Takuwa, H., Maeda, J., Ono, M., Tokunaga, M., Nitta, N., Honda, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.20.671400
Epilepsy and EEG abnormalities in neurodegenerative dementias: toward a system epilepsy framework
Manganotti, P., Palacino, F., Pavan, S., & Benussi, A. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1806471
Altered neuronal activity in the hippocampal CA3 region in an in vitro model of tauopathy
Goncalves, A. (2020) · theses.fr (ABES) · doi:10.70675/b42db6dez88a0z4a14z93eez8f51d19d46f5
The neuropathology of “dementia epileptica”Preprint
Lautsen, S. E., Petersen, J. K., Cornwall, C. D., Wirenfeldt, M., & Beier, C. P. (2026) · medRxiv · doi:10.64898/2026.04.29.26352020
Microtubule affinity-regulating kinases in neurodegenerative disorders
Shahwan, M. J., Anwar, S., Alrouji, M., AlOmeir, O., Dinislam, K., & Shamsi, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44173-8.00014-0
Lautsen, S. E., Petersen, J. K., Cornwall, C. D., Wirenfeldt, M., & Beier, C. P. (2026) · Epilepsy Research · doi:10.1016/j.eplepsyres.2026.107910
Human P301L tau expression in mice alters neuronal excitability independent of neurodegeneration
Dunton, K. L., Monchal, H., Achorn, B. E., Mandé‐Niedergang, B., Roucard, C., Roche, Y., Evrard, A., & Menniti, F. S. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1814637
Metadata
- Authors
- Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J.
- Affiliations
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Laboratory of Neurology, IIS (Instituto Investigación Sanitaria/Health Research Institute)-Jiménez Díaz Foundation, UAM (Universidad Autonoma de Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on Rare Diseases (CIBERER), 28045 Madrid, Spain
- Corresponding author
- Sánchez, Marina
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-04-05
- Volume
- 19
- Issue
- 4
- Pages
- 1092
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC5979593
- OpenAlex
- W2795704013
- Cited by
- 68
- References
- 217
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 7 · 2021: 14 · 2020: 10 · 2019: 5 · 2018: 3
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Carlos III Institute of Health (PI13/00865)
- Biomedical Research Network Center on Rare Diseases, CIBERER
- NINDS, NIH (P01NS097197)
- Spanish Ministry of Economy (SAF2014-59594-R)
- Conchita Rábago Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- tau pathology, epilepsy, dementia, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, progressive supranuclear palsy, MAPT mutations, amyloid plaques, neuropil threads, network hyperexcitability, cognitive decline, FTDP-17, antiepileptic drugs, animal models, early diagnosis
- MeSH terms
- Animals, Brain, Dementia, Epilepsy, Humans, tau Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
