β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle
Open accessAbstract
The clinical benefit of ketosis has historically and almost exclusively centered on neurological conditions, lending insight into how ketones alter mitochondrial function in neurons. However, there is a gap in our understanding of how ketones influence mitochondria within skeletal muscle cells. The purpose of this study was to elucidate the specific effects of β-hydroxybutyrate (β-HB) on muscle cell mitochondrial physiology. In addition to increased cell viability, murine myotubes displayed beneficial mitochondrial changes evident in reduced H2O2 emission and less mitochondrial fission, which may be a result of a β-HB-induced reduction in ceramides. Furthermore, muscle from rats in sustained ketosis similarly produced less H2O2 despite an increase in mitochondrial respiration and no apparent change in mitochondrial quantity. In sum, these results indicate a general improvement in muscle cell mitochondrial function when β-HB is provided as a fuel.
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β-hydroxybutyrate elicits favorable mitochondrial adaptations in myocytes.
“and elicits favorable mitochondrial adaptations in myocytes [176]”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [176]
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“Interestingly, the ketone body βhydroxybutyrate, which is elevated during nutritional ketosis, was shown to induce mitophagy in young and aged myocytes [175] and elicits favorable mitochondrial adaptations in myocytes [176].”
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The Metabolic Effects of Ketones
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- Authors
- Parker, B. A., Walton, C. M., Carr, S. T., Andrus, J. L., Cheung, E. C. K., Duplisea, M. J., Wilson, E. K., Draney, C., Lathen, D. R., Kenner, K. B., Thomson, D. M., Tessem, J. S., & Bikman, B. T.
- Affiliations
- Brigham Young University (US)
- Department of Nutrition, Dietetics and Food Science, Brigham Young University, Provo, UT 84604, USA
- Corresponding author
- Bikman, Benjamin T.
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-08-01
- Volume
- 19
- Issue
- 8
- Pages
- 2247
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6121962
- OpenAlex
- W2887071106
- Cited by
- 52
- References
- 41
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 3
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- beta-hydroxybutyrate, ketosis, skeletal muscle, mitochondrial function, mitochondrial fission, hydrogen peroxide, ceramide, mitochondrial respiration, myotubes, cell viability
- MeSH terms
- Animals, Ceramides, Mitochondria, Muscle, Oxygen Consumption, Muscle, Skeletal, 3-Hydroxybutyric Acid, Mice
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