Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1

Tanner, Colby B.; Madsen, Steven R.; Hallowell, David M.; Goring, Darren M. J.; Moore, Timothy M.; Hardman, Shalene E.; Heninger, Megan R.; Atwood, Daniel R.; Thomson, David M.

doi:10.1152/ajpendo.00227.2013

Cited by 47Cardiovascular and exercise physiologyAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1

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Tanner, Colby B., Madsen, Steven R., Hallowell, David M., Goring, Darren M. J., Moore, Timothy M., Hardman, Shalene E., Heninger, Megan R., Atwood, Daniel R. +1 more·2013·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00227.2013PMC PMC3798697

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Abstract

LKB1 and its downstream targets of the AMP-activated protein kinase family are important regulators of many aspects of skeletal muscle cell function, including control of mitochondrial content and capillarity. LKB1 deficiency in skeletal and cardiac muscle (mLKB1-KO) greatly impairs exercise capacity. However, cardiac dysfunction in that genetic model prevents a clear assessment of the role of skeletal muscle LKB1 in the observed effects. Our purposes here were to determine whether skeletal muscle-specific knockout of LKB1 (skmLKB1-KO) decreases exercise capacity and mitochondrial protein content, impairs accretion of mitochondrial proteins after exercise training, and attenuates improvement in running performance after exercise training. We found that treadmill and voluntary wheel running capacity was reduced in skmLKB1-KO vs. control (CON) mice. Citrate synthase activity, succinate dehydrogenase activity, and pyruvate dehydrogenase kinase content were lower in KO vs. CON muscles. Three weeks of treadmill training resulted in significantly increased treadmill running performance in both CON and skmLKB1-KO mice. Citrate synthase activity increased significantly with training in both genotypes, but protein content and activity for components of the mitochondrial electron transport chain increased only in CON mice. Capillarity and VEGF protein was lower in skmLKB1-KO vs. CON muscles, but VEGF increased with training only in skmLKB1-KO. Three hours after an acute bout of muscle contractions, PGC-1α, cytochrome c, and VEGF gene expression all increased in CON but not skmLKB1-KO muscles. Our findings indicate that skeletal muscle LKB1 is required for accretion of some mitochondrial proteins but not for early exercise capacity improvements with exercise training.

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AMPK plays a key role in controlling running capacity and certain adaptive processes in response to endurance exercise training.
“AMPK also plays a key role in controlling running capacity and certain adaptive processes in response to endurance exercise training [25,26].”
From New strategies in sport nutrition to increase exercise performance (2016) · cites this paper as [25]

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Time-course Of Increases Of Lkb1, Citrate Synthase, And Hexokinase With Endurance Training In Muscle
Taylor, E. B., Lamb, J. D., Hurst, R. W., et al. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-200505001-02294

Authors: Tanner, C. B., Madsen, S. R., Hallowell, D. M., Goring, D. M. J., Moore, T. M., Hardman, S. E., Heninger, M. R., Atwood, D. R., & Thomson, D. M.
Affiliations: Brigham Young University (US)
Corresponding author: Thomson, David M.
ORCID: Moore, Timothy M.
Thomson, David M.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2013-10-15
Volume: 305
Issue: 8
Pages: E1018-E1029
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00227.2013
PMC: PMC3798697
OpenAlex: W2167703406
Cited by: 47
References: 55
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2021: 2 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 8
FWCI: 13.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Figshare (submittedVersion, cc-by)
Funders: National Institutes of Health (5r01ar051928-05)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01 AR-051928)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: LKB1, skeletal muscle, exercise training, exercise capacity, mitochondrial protein content, mitochondrial biogenesis, AMPK, citrate synthase, succinate dehydrogenase, pyruvate dehydrogenase kinase, electron transport chain, capillarization, vascular endothelial growth factor, PGC-1α, cytochrome c, voluntary wheel running
MeSH terms: Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Adaptation, Physiological, Animals, Capillaries, Citrate (si)-Synthase, Citric Acid Cycle, Female, Male, Mitochondria, Muscle, Motor Activity, Motor Skills, RNA, Messenger, Succinate Dehydrogenase, Gene Expression Regulation, Enzymologic, Protein Serine-Threonine Kinases, Mice, Knockout, Muscle, Skeletal, Vascular Endothelial Growth Factor A, Mice, AMP-Activated Protein Kinases

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Mitochondrial and performance adaptations to exercise training in mice lacking skeletal muscle LKB1

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