The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Repair of Damaged Articular Cartilage: Current Approaches and Future Directions
Open accessAbstract
Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environment in vivo during cell expansion and differentiation into mature chondrocytes.
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Cited by
Mammalian Pericardium‐Based Bioprosthetic Materials in Xenotransplantation and Tissue Engineering
Grebenik, E. A., Gafarova, E. R., Istranov, L. P., Istranova, E. V., Ma, X., Xu, J., Guo, W., Atala, A., & Timashev, P. S. (2020) · Biotechnology Journal · doi:10.1002/biot.201900334 · Cited by 30
Self-citation
Metadata
- Authors
- Medvedeva, E. V., Grebenik, E. A., Gornostaeva, S. N., Telpuhov, V. I., Lychagin, A. V., Timashev, P. S., & Chagin, A. S.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-08-11
- Volume
- 19
- Issue
- 8
- Pages
- 2366
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2885484867
- Cited by
- 266
- References
- 155
- FWCI
- 20.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Medvedeva, E. V., Grebenik, E. A., Gornostaeva, S. N., Telpuhov, V. I., Lychagin, A. V., Timashev, P. S., & Chagin, A. S. (2018). Repair of Damaged Articular Cartilage: Current Approaches and Future Directions. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19082366
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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