The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives
Open accessAbstract
Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein. This molecular mechanism is the molecular basis of anthracycline anticancer activity as well as the toxic effects such as cardiomyopathy and induction of secondary cancers. Even though anthracyclines have been used in the clinic for more than 50 years for solid and blood cancers, the search of breakthrough analogs has substantially failed. The recent developments of personalized medicine, availability of individual genomic information, and immune therapy are expected to change significantly human cancer therapy. Here, we discuss the knowledge of anthracyclines as Topoisomerase II poisons, their molecular and cellular effects and toxicity along with current efforts to improve the therapeutic index. Then, we discuss the contribution of the immune system in the anticancer activity of anthracyclines, and the need to increase our knowledge of molecular mechanisms connecting the drug targets to the immune stimulatory pathways in cancer cells. We propose that the complete definition of the molecular interaction of anthracyclines with the immune system may open up more effective and safer ways to treat patients with these drugs.
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Citations
Cites
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Cited by
Ligands stimulating antitumour immunity as the next G-quadruplex challenge
Miglietta, G., Marinello, J., Russo, M., & Capranico, G. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01649-y · Cited by 44
“and topoisomerase‐mediated genome instability Immuno-modulation activity has been proposed also for Topoisomerase poisons arguing that immune-stimulation can contribute significantly to the therapeutic activity of established anticancer agents in patients [114, 115].”
BackgroundSelf-citationInsights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death
Kopecka, J., Godel, M., Dei, S., Giampietro, R., Belisario, D. C., Akman, M., Contino, M., Teodori, E., & Riganti, C. (2020) · Cells · doi:10.3390/cells9041033 · Cited by 41
Metadata
- Authors
- Marinello, J., Delcuratolo, M., & Capranico, G.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-06
- Volume
- 19
- Issue
- 11
- Pages
- 3480
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2899552791
- Cited by
- 258
- References
- 96
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- gold
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- Marinello, J., Delcuratolo, M., & Capranico, G. (2018). Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms19113480
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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