Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
Abstract
The release of adenosine triphosphate through autophagy can promote antitumor immune responses.
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Pre-mortem autophagy is required for optimal ATP release during ICD and for immunogenicity of cell death induced by several but not all ICD inducers.
“Accordingly, pre-mortem autophagy is required for optimal ATP release in the course of ICD, and hence for cell death induced by several (but not all) ICD inducers to be perceived as immunogenic [867, 900, 901].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [867]
Six DAMPs have been mechanistically linked to perception of RCD as immunogenic: CALR, ATP, HMGB1, type I IFN, cancer cell-derived nucleic acids, and ANXA1.
“So far, six DAMPs have been mechanistically linked to the perception of RCD as immunogenic: (1) calreticulin (CALR) [865, 866], (2) ATP [867–869], (3) high-mobility group box 1 (HMGB1) [870–872], (4) type I IFN [854, 873, 874], (5) cancer cell-derived nucleic acids [864, 875], and (6) annexin A1 (ANXA1) [876].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [867]
Intact autophagy responses regulate the adjuvanticity and antigenicity of tumor cells, thereby promoting the establishment of the cancer-immunity cycle leading to CTL-dependent elimination of malignant cells.
“In contrast to these findings, intact autophagy responses regulate (i) the adjuvanticity (e.g., the capacity to emit danger signals that are preliminary to the recruitment of immune cells to the tumor bed) (Michaud et al, 2011; Zitvogel et al, 2015; Garg et al, 2016) and (ii) antigenicity of tumor cells (Caron et al, 2011; Ma et al, 2013c; Pietrocola et al, 2017), thereby promoting the establis”
From Autophagy in major human diseases (2021) · cites this paper as Michaud et al, 2011
Autophagy-deficient tumors transplanted into immunocompetent mice escape immunosurveillance due to their inability to secrete immunostimulatory ATP.
“In line with this observation, autophagy‐deficient tumors transplanted into immunocompetent mice escape immunosurveillance, due to their inability to secrete immunostimulatory ATP (Michaud et al, 2011)”
From Autophagy in major human diseases (2021) · cites this paper as Michaud et al, 2011
Autophagy activation in cancer cells dying from chemotherapy is required for the cell death to be perceived as immunogenic.
“autophagy activation in cancer cells succumbing to chemotherapy is critical for cell death to be perceived as immunogenic (Box 1) (Michaud et al., 2011)”
From Immunomodulation by targeted anticancer agents (2021) · cites this paper as Michaud et al., 2011
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- Authors
- Michaud, M., Martins, I., Sukkurwala, A. Q., Adjemian, S., Ma, Y., Pellegatti, P., Shen, S., Kepp, O., Scoazec, M., Mignot, G., Rello-Varona, S., Tailler, M., Menger, L., Vacchelli, E., Galluzzi, L., Ghiringhelli, F., di Virgilio, F., Zitvogel, L., & Kroemer, G.
- Affiliations
- Université Paris-Sud (FR)
- University of Ferrara (IT)
- Institut Gustave Roussy (FR)
- Inserm (FR)
- INSERM, U848, Villejuif, France.
- Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy.
- Corresponding author
- Michaud, Mickaël
- Martins, Isabelle
- Zitvogel, Laurence
- Kroemer, Guido
- ORCID
- Venue
- Science
- Published
- 2011-12-16
- Volume
- 334
- Issue
- 6062
- Pages
- 1573-1577
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999998145
- Cited by
- 1,377
- References
- 10
- Citations by year
- 2026: 63 · 2025: 62 · 2024: 73 · 2023: 91 · 2022: 111 · 2021: 109 · 2020: 131 · 2019: 92 · 2018: 98 · 2017: 91 · 2016: 89 · 2015: 74 · 2014: 84 · 2013: 117 · 2012: 89
- FWCI
- 70.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- autophagy, immunogenic cell death, chemotherapy, antitumor immunity, extracellular ATP, dendritic cells, T cells
- MeSH terms
- Adenosine Triphosphate, Animals, Antineoplastic Agents, Autophagy, Dendritic Cells, Humans, Mice, Inbred BALB C, Mice, Inbred C57BL, Mitoxantrone, Neoplasms, Cell Death, Calreticulin, Cell Line, Tumor, Mice
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