Regulation of iNOS on Immune Cells and Its Role in Diseases
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In recent years, there have been many studies on the function of nitric oxide synthase (NOS) in experimental animals and humans. This review analyzes and explores the relationship between inducible nitric oxide synthase (iNOS) and T cells, macrophages, and dendritic cell et al. differentiation using data based on laboratory research, highlighting recent NOS laboratory research. Our insights into research prospects and directions are also presented.
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Endothelial eNOS and neuronal nNOS are controlled by calmodulin and, under stimulation, the inducible isoform iNOS is involved in the immune response, producing large amounts of •NO as an immune defense mechanism.
“Endothelial eNOS and neuronal nNOS are controlled by calmodulin and, under stimulation, the inducible isoform of iNOS is involved in the immune response, producing large amounts of -NO as an immune defense mechanism [105].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [105]
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Cited by
Sorted by citations
The Role of Reactive Species on Innate Immunity
Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works
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- Authors
- Xue, Q., Yan, Y., Zhang, R., & Xiong, H.
- Affiliations
- Jining Medical University (CN)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Xiong, Huabao
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-29
- Volume
- 19
- Issue
- 12
- Pages
- 3805
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6320759
- OpenAlex
- W2903108867
- Cited by
- 421
- References
- 74
- Citations by year
- 2026: 31 · 2025: 58 · 2024: 52 · 2023: 73 · 2022: 79 · 2021: 67 · 2020: 45 · 2019: 14
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31500056)
- Nature Science Foundation of Shandong Province (2018GSF118137)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- inducible nitric oxide synthase, nitric oxide, T cells, macrophages, dendritic cells, immune cell differentiation, immune regulation
- MeSH terms
- Animals, Dendritic Cells, Humans, Macrophages, T-Lymphocytes, Nitric Oxide Synthase Type II
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