Role of immunogenetics in the outcome of HCMV infection: implications for ageing
Open accessAbstract
The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors. Therefore, different individuals vary in their relative susceptibility to infections. Human cytomegalovirus (HCMV) is an important pathogen from a clinical point of view, as it causes significant morbidity and mortality in immunosuppressed or immunosenescent individuals, such as the transplanted patients and the elderly, respectively. It is, therefore, important to understand the mechanisms of virus infection control. In this review, we discuss recent advances in the immunobiology of HCMV-host interactions, with particular emphasis on the immunogenetic aspects (human leukocyte antigens, HLA; killer cell immunoglobulin-like receptors, KIRs; immunoglobulin genetic markers, GM allotypes) to elucidate the mechanisms underlying the complex host-virus interaction that determine various outcomes of HCMV infection. The results, which show the role of humoral and cellular immunity in the control of infection by HCMV, would be valuable in directing efforts to reduce HCMV spurred health complications in the transplanted patients and in the elderly, including immunosenescence. In addition, concerning GM allotypes, it is intriguing that, in a Southern Italian population, alleles associated with the risk of developing HCMV symptomatic infection are negatively associated with longevity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several factors, such as genetics, nutrition, exercise, previous exposure to microorganisms, biological and cultural sex, and HCMV status, can influence immunosenescence.
“Several factors, such as genetics, nutrition, exercise, previous exposure to microorganisms, biological and cultural sex, and human cytomegalovirus (HCMV) status can influence immunosenescence (3, 6–11).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [7]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection
Cannon, M. J., Schmid, D. S., & Hyde, T. B. (2010) · Reviews in Medical Virology · doi:10.1002/rmv.655 · Cited by 1,495 · see citing works
NKG2D Receptor and Its Ligands in Host Defense
Lanier, L. L. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0098 · Cited by 599 · see citing works
The pathogenesis of human cytomegalovirus
Griffiths, P., Baraniak, I., & Reeves, M. B. (2014) · The Journal of Pathology · doi:10.1002/path.4437 · Cited by 594 · see citing works
Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments
Gandhi, M. K., & Khanna, R. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01202-2 · Cited by 564 · see citing works
Genetic Control of Human NK Cell Repertoire
Shilling, H. G., Young, N. T., Guethlein, L. A., Cheng, N. W., Gardiner, C. M., Tyan, D. B., & Parham, P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.1.239 · Cited by 245 · see citing works
Genetic susceptibility to infectious diseases: big is beautiful (and will bigger be even better?)
Burgner, D., Jamieson, S., & Blackwell, J. (2006) · Lancet. Infectious Diseases (Print) · doi:10.1016/s1473-3099(06)70601-6 · Cited by 234 · see citing works
A model for reactivation of CMV from latency
Hummel, M., & Abecassis, M. M. (2002) · Journal of Clinical Virology · doi:10.1016/s1386-6532(02)00088-4 · Cited by 210 · see citing works
The Immune Response to Human CMV
Rosa, C. L., & Diamond, D. J. (2012) · Future Virology · doi:10.2217/fvl.12.8 · Cited by 190 · see citing works
Cytomegalovirus Infection in Immunocompetent Patients
Wreghitt, T. G., Teare, E. L., Sule, O., Devi, R., & Rice, P. (2003) · Clinical Infectious Diseases · doi:10.1086/379711 · Cited by 182 · see citing works
Cook, M. A. (2005) · Blood · doi:10.1182/blood-2005-03-1039 · Cited by 172 · see citing works
A new synthesis for antibody-mediated immunity
Casadevall, A., & Pirofski, L. (2011) · Nature Immunology · doi:10.1038/ni.2184 · Cited by 145 · see citing works
The impact of CMV infection on survival in older humans
Pawelec, G., McElhaney, J. E., Aiello, A. E., & Derhovanessian, E. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.002 · Cited by 145 · see citing works
Self-citationLefranc, M., & Lefranc, G. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-842-9_34 · Cited by 129 · see citing works
Feeling manipulated: cytomegalovirus immune manipulation
Miller-Kittrell, M., & Sparer, T. E. (2009) · Virology Journal · doi:10.1186/1743-422x-6-4 · Cited by 129 · see citing works
Parry, H. M., Zuo, J., Frumento, G., Mirajkar, N., Inman, C., Edwards, E., Griffiths, M., Pratt, G., & Moss, P. (2016) · Immunity & Ageing · doi:10.1186/s12979-015-0056-6 · Cited by 125 · see citing works
GENETIC CONTROL OF SURVIVAL IN EPIDEMICS
de Vries, R. R. P., Khan, P. M., Bernini, L. F., van Loghem, E., & van Rood, J. J. (1979) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.1979.tb00684.x · Cited by 113 · see citing works
Stern, M., Elsässer, H., Hönger, G., Steiger, J., Schaub, S., & Hess, C. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02242.x · Cited by 109 · see citing works
Genomewide Association Studies and Assessment of Risk of Disease
Rienhoff, H. Y. (2010) · New England Journal of Medicine · doi:10.1056/nejmc1010310 · Cited by 104 · see citing works
Broadley, I., Pera, A., Morrow, G., Davies, K. A., & Kern, F. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00195 · Cited by 103 · see citing works
Immune-inflammatory responses in the elderly: an update
Accardi, G., & Caruso, C. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0117-8 · Cited by 102 · see citing works
Self-citationZaia, J. A., Sun, J. Y., Gallez-Hawkins, G. M., Thao, L., Oki, A., Lacey, S. F., Dagis, A., Palmer, J. M., Diamond, D. J., Forman, S. J., et al. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2008.11.030 · Cited by 95 · see citing works
CMV immune evasion and manipulation of the immune system with aging
Jackson, S. E., Redeker, A., Arens, R., van Baarle, D., van den Berg, S. P. H., Benedict, C. A., Čičin‐Šain, L., Hill, A. B., & Wills, M. R. (2017) · GeroScience · doi:10.1007/s11357-017-9986-6 · Cited by 90 · see citing works
J. B. S. Haldane () on Infectious Disease and Evolution
Lederberg, J. (1999) · Genetics · doi:10.1093/genetics/153.1.1 · Cited by 89 · see citing works
HLA, aging, and longevity: a critical reappraisal
Caruso, C., Candore, G., Romano, G. C., Lio, D., Bonafè, M., Valensin, S., & Franceschi, C. (2000) · Human Immunology · doi:10.1016/s0198-8859(00)00168-3 · Cited by 85 · see citing works
Self-citationHadaya, K., de Rham, C., Bandelier, C., Bandelier, C., Ferrari‐Lacraz, S., Jendly, S., Berney, T., Bühler, L. H., Kaiser, L., Seebach, J. D., et al. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2008.02431.x · Cited by 79 · see citing works
Caruso, C., Candore, G., Romano, G. C., Lio, D., Bonafè, M., Valensin, S., & Franceschi, C. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00255-4 · Cited by 77 · see citing works
Self-citationExpression of KIR2DL1 on the entire NK cell population: a possible novel immunodeficiency syndrome
Gazit, R., Garty, B., Monselise, Y., Hoffer, V., Finkelstein, Y., Markel, G., Katz, G., Hanna, J. H., Achdout, H., Gruda, R., et al. (2004) · Blood · doi:10.1182/blood-2003-11-3796 · Cited by 72 · see citing works
Autoimmune diseases and 8.1 ancestral haplotype: An update
Gambino, C. M., Aiello, A., Accardi, G., Caruso, C., & Candore, G. (2018) · HLA · doi:10.1111/tan.13305 · Cited by 68 · see citing works
Self-citationOxelius, V., & Pandey, J. P. (2013) · Clinical Immunology · doi:10.1016/j.clim.2013.10.003 · Cited by 61 · see citing works
Self-citationNikolich-Žugich, J., & van Lier, R. A. W. (2017) · GeroScience · doi:10.1007/s11357-017-9984-8 · Cited by 59 · see citing works
CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity
Corrales‐Aguilar, E., Hoffmann, K., & Hengel, H. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0448-2 · Cited by 55 · see citing works
Souquette, A. H., Frere, J. J., Smithey, M. J., Sauce, D., & Thomas, P. G. (2017) · GeroScience · doi:10.1007/s11357-017-9982-x · Cited by 44 · see citing works
Cytomegalovirus Reactivation in “Immunocompetent” Patients: A Call for Scientific Prophylaxis
Cook, C. H. (2007) · The Journal of Infectious Diseases · doi:10.1086/522433 · Cited by 40 · see citing works
The distribution of HLA antigens in Italy.
Piazza, A., Olivetti, E., Griffo, R. M., Rendine, S., Amoroso, A., Barbanti, M., Caruso, C., Conighi, C., Conte, R., & Favoino, B. (1989) · PubMed · Cited by 40 · see citing works
Self-citationHLA and Killer Cell Immunoglobulin-like Receptors Influence the Natural Course of CMV Infection
Bona, D. D., Scafidi, V., Plaia, A., Colomba, C., Nuzzo, D., Occhino, C., Tuttolomondo, A., Giammanco, A., Grazia, S. D., Montalto, G., et al. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu226 · Cited by 35 · see citing works
Self-citationKilgour, A. H. M., Firth, C. M., Harrison, R., Moss, P. A. H., Bastin, M. E., Wardlaw, J. M., Deary, I. J., & Starr, J. M. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-33 · Cited by 31 · see citing works
THE INFLUENCE OF HLA A-B-DR MATCHING ON CYTOMEGALOVIRUS DISEASE AFTER RENAL TRANSPLANTATION
Blancho, G., Josien, R., Douillard, D., Bignon, J. D., Cesbron, A., & Soulillou, J. (1992) · Transplantation · doi:10.1097/00007890-199211000-00020 · Cited by 29 · see citing works
Kraat, Y. J., Christiaans, M. H. L., Nieman, F. H. M., van den Berg-Loonen, P. M., van Hooff, J. P., & Bruggeman, C. A. (1994) · Transplant International · doi:10.1007/bf00336713 · Cited by 28 · see citing works
Yang, F., Shu, K.-H., Chen, H., Chen, I., Lay, F.-Y., Chuang, Y., Wu, C., Tsai, W., Peng, Y., Hsu, S., et al. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0120-0 · Cited by 28 · see citing works
Namboodiri, A. M., & Pandey, J. P. (2011) · Archives of Virology · doi:10.1007/s00705-011-0937-8 · Cited by 27 · see citing works
Self-citationImmunoglobulin Genes Influence the Magnitude of Humoral Immunity to Cytomegalovirus Glycoprotein B
Pandey, J. P., Kistner‐Griffin, E., Radwan, F. F. Y., Kaur, N., Namboodiri, A. M., Black, L. E., Butler, M. A., Carreón, T., & Ruder, A. M. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu367 · Cited by 24 · see citing works
Self-citationIdentification of HLA-B44 subtypes associated with extended MHC haplotypes
Kruskall, M. S., Eynon, E. E., Awdeh, Z., Alper, C. A., & Yunis, E. J. (1987) · Immunogenetics · doi:10.1007/bf00346515 · Cited by 23 · see citing works
Increased frequency of CMV infection in HLA-DR7 matched renal allograft recipients
Kraat, Y. J., Christiaans, M. H. L., Nieman, F. H. M., van den Berg-Loonen, P. M., van Hooff, J. P., & Bruggeman, C. A. (1993) · The Lancet · doi:10.1016/0140-6736(93)90248-f · Cited by 21 · see citing works
Misra, M. K., Augusto, D. G., Montero-Martín, G., Nemat‐Gorgani, N., Sauter, J., Hofmann, J. A., Traherne, J. A., González-Quezada, B. A., Gorodezky, C., Bultitude, W. P., et al. (2018) · Human Immunology · doi:10.1016/j.humimm.2018.10.003 · Cited by 20 · see citing works
Kraat, Y. J., Christiaans, M. H. L., Nieman, F. H. M., et al. (1994) · Transplant International · doi:10.1111/j.1432-2277.1994.tb01248.x · Cited by 20 · see citing works
Naumova, E. J., Ivanova, M., Pawelec, G., Constantinescu, I., Bogunia‐Kubik, K., Lange, A., Qguz, F., Carin, M. N., Franceschi, C., Caruso, C., et al. (2011) · Tissue Antigens · doi:10.1111/j.1399-0039.2010.01603.x · Cited by 18 · see citing works
Self-citationKuparinen, T., Seppälä, I., Jylhävä, J., Marttila, S., Aittoniemi, J., Kettunen, J., Viikari, J. S. A., Kähönen, M. A. P., Raitakari, O. T., Lehtimäki, T. J., et al. (2011) · Genes and Immunity · doi:10.1038/gene.2011.71 · Cited by 18 · see citing works
Cytomegalovirus Infection in Ireland
Hassan, J., O’Neill, D., Honari, B., Gascun, C. F. D., Connell, J., Keogan, M. T., & Hickey, D. P. (2016) · Medicine · doi:10.1097/md.0000000000002735 · Cited by 18 · see citing works
Bona, D. D., Accardi, G., Aiello, A., Bilancia, M., Candore, G., Colomba, C., Caruso, C., Duro, G., Gambino, C. M., Macchia, L., et al. (2017) · Immunology · doi:10.1111/imm.12855 · Cited by 18 · see citing works
Self-citationCandidate Gene Approach's Missing Link
Pandey, J. P. (2010) · Science · doi:10.1126/science.329.5996.1148 · Cited by 15 · see citing works
Self-citationHuman Leukocyte Antigen Alleles and Cytomegalovirus Infection After Renal Transplantation
Futohi, F., Saber, A., Nemati, E., Einollahi, B., & Rostami, Z. (2015) · Nephro-Urology Monthly · doi:10.5812/numonthly.31635 · Cited by 15 · see citing works
Genetic markers of immunoglobulin G and immunity to cytomegalovirus in patients with breast cancer
Pandey, J. P., Namboodiri, A. M., Mohan, S., Nietert, P. J., & Peterson, L. L. (2016) · Cellular Immunology · doi:10.1016/j.cellimm.2016.11.003 · Cited by 15 · see citing works
Self-citationPandey, J. P., Namboodiri, A. M., Radwan, F. F. Y., & Nietert, P. J. (2015) · Human Immunology · doi:10.1016/j.humimm.2015.09.005 · Cited by 14 · see citing works
Self-citationAiello, A., Candore, G., Accardi, G., Caruso, C., Colomba, C., Duro, G., Gambino, C. M., Ligotti, M. E., & Bona, D. D. (2018) · Current Pharmaceutical Design · doi:10.2174/1381612824666180911123249 · Cited by 14 · see citing works
Self-citationPuca, A. A., Ferrario, A., Maciag, A. E., Accardi, G., Aiello, A., Gambino, C. M., Candore, G., Caruso, C., Namboodiri, A. M., & Pandey, J. P. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0134-7 · Cited by 11 · see citing works
Self-citationGenetics of exceptional longevity: possible role of GM allotypes
Caruso, C., Pandey, J. P., & Puca, A. A. (2018) · Immunity & Ageing · doi:10.1186/s12979-018-0133-8 · Cited by 11 · see citing works
Self-citation16th IHIW: Immunogenetics of Aging
Naumova, E. J., Ivanova, M., Pawelec, G., Constantinescu, I., Bogunia‐Kubik, K., Lange, A., Oğuz, F. S., Özdilli, K., Franceschi, C., Caruso, C., et al. (2013) · International Journal of Immunogenetics · doi:10.1111/iji.12027 · Cited by 10 · see citing works
Self-citationWeinberger, B., Keller, M., & Grubeck‐Loebenstein, B. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0099-y · Cited by 6 · see citing works
Genetic Variation in Human Leukocyte Antigen and Susceptibility to Acute Myeloid Leukemia
Rizzo, C., Accardi, G., & Caruso, C. (2014) · Acta Haematologica · doi:10.1159/000365879 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- [7]Roizman B. Pellet P.E. The Family Herpesviridae: A Brief Introduction Fields Virology Knipe D.M. Howley P.M. Raven Press New York, NY, USA 2001 2381 2397
- [34]Aiello A. Accardi G. Candore G. Gambino C.M. Caruso C. Di Bona D. The importance of interactions between KIRs and HLA ligands in the development of autoimmune and viral diseases Causality and Chance in Ageing, Age-Related Diseases and Longevity, Proceedings of the Symposium Updated in Pathobiology, Palermo, Italy, 24 March 2017 Caruso C. Accardi G. Unipapress Palermo, Italy 2017 91 110
Cited by
Sorted by citations
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Self-citationImmunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience
Moskalev, A., Stambler, I., & Caruso, C. (2020) · Aging and Disease · doi:10.14336/ad.2020.0603 · Cited by 71 · see citing works
Self-citationBaba, R. E., & Herbein, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.730765 · Cited by 66 · see citing works
An immunologist’s guide to immunosenescence and its treatment
Caruso, C., Ligotti, M. E., Accardi, G., Aiello, A., & Candore, G. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2106217 · Cited by 53 · see citing works
Self-citationFunctional Changes of T-Cell Subsets with Age and CMV Infection
Hassouneh, F., Goldeck, D., Pera, A., van Heemst, D., Slagboom, P. E., Pawelec, G., & Solana, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189973 · Cited by 47 · see citing works
Ligotti, M. E., Aiello, A., Accardi, G., Aprile, S., Bonura, F., Bulati, M., Gervasi, F., Giammanco, G. M., Pojero, F., Zareian, N., et al. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13606 · Cited by 46 · see citing works
Self-citationThe Role of Immunogenetics in COVID-19
Pojero, F., Candore, G., Caruso, C., Bona, D. D., Groneberg, D. A., Ligotti, M. E., Accardi, G., & Aiello, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052636 · Cited by 41 · see citing works
Self-citationLigotti, M. E., Accardi, G., Aiello, A., Aprile, S., Calabrò, A., Caldarella, R., Caruso, C., Ciaccio, M., Corsale, A. M., Dieli, F., et al. (2023) · Clinical & Experimental Immunology · doi:10.1093/cei/uxad074 · Cited by 31 · see citing works
Self-citationCox, M., Kartikasari, A. E. R., Gorry, P. R., Flanagan, K. L., & Plebanski, M. (2021) · Biomedicines · doi:10.3390/biomedicines9040351 · Cited by 30 · see citing works
Immunosenescence promotes cancer development: from mechanisms to treatment strategies
Wang, L., & Tang, D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02082-6 · Cited by 30 · see citing works
Challenges and Clinical Implications of the Diagnosis of Cytomegalovirus Lung Infection in Children
Gualteros, S. M. R., Gutierrez, M. J., Villamil‐Osorio, M., Arroyo, M., & Niño, G. (2019) · Current Infectious Disease Reports · doi:10.1007/s11908-019-0681-x · Cited by 24 · see citing works
Domaszewska, K., Boraczyński, M., Tang, Y., Gronek, J., Wochna, K., Boraczyński, T., Wieliński, D., & Gronek, P. (2022) · Aging and Disease · doi:10.14336/ad.2021.1219 · Cited by 20 · see citing works
Cytomegalovirus as an Uninvited Guest in the Response to Vaccines in People Living with HIV
Royston, L., Isnard, S., Lin, J. C.-Y., & Routy, J. (2021) · Viruses · doi:10.3390/v13071266 · Cited by 19 · see citing works
Intrinsic Immune Mechanisms Restricting Human Cytomegalovirus Replication
Schilling, E.-M., Scherer, M., & Stamminger, T. (2021) · Viruses · doi:10.3390/v13020179 · Cited by 14 · see citing works
Ligotti, M. E., Aiello, A., Accardi, G., Calabrò, A., Ciaccio, M., Colomba, C., Bona, D. D., Sasso, B. L., Pojero, F., Tuttolomondo, A., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415466 · Cited by 11 · see citing works
Self-citationGrabarek, B. O., Ossowski, P., Czarniecka, J., Ożóg, M. K., Prucnal, J., Dziuba, I., Остенда, А., Dziobek, K., Boroń, D., Peszek, W., et al. (2023) · Pathogens · doi:10.3390/pathogens12030397 · Cited by 9 · see citing works
Auma, A. W. N., Shive, C. L., Kostadinova, L., & Anthony, D. D. (2021) · Viruses · doi:10.3390/v14010050 · Cited by 9 · see citing works
Thymic function and survival at advance ages in nursing home residents from Southern Italy
Paparazzo, E., Geracitano, S., Lagani, V., Citrigno, L., Bartolomeo, D., Aceto, M. A., Bruno, F., Maletta, R., Passarino, G., & Montesanto, A. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00340-0 · Cited by 7 · see citing works
The role and research progress of macrophages after heart transplantation
Chen, Y., Wang, J., An, C., Bao, S., & Zhang, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e33844 · Cited by 6 · see citing works
Deciphering the Potential Coding of Human Cytomegalovirus: New Predicted Transmembrane Proteome
Mancebo, F. J., Parras-Moltó, M., García‐Ríos, E., & Pérez‐Romero, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052768 · Cited by 6 · see citing works
Anti-Cytomegalovirus Therapy: Whether and When to Initiate, Those Are the Questions
Aoyama, Y., Sugiyama, S., & Yamamoto, T. (2022) · Pharmaceuticals · doi:10.3390/ph15070797 · Cited by 6 · see citing works
Immunotherapy in Elderly Patients—Single-Center Experience
Ramos, M. J., Mendes, A. S., Romão, R., Febra, J., & Araújo, A. (2023) · Cancers · doi:10.3390/cancers16010145 · Cited by 6 · see citing works
Lessons from Sicilian centenarians for anti-ageing medicine. The Oxi-inflammatory status
Caruso, C., Accardi, G., Aiello, A., Calabrò, A., Ligotti, M. E., & Candore, G. (2022) · Translational Medicine UniSa · doi:10.37825/2239-9747.1036 · Cited by 5 · see citing works
Self-citationCianfruglia, L., Fortunato, C., Pazmay, G. V. B., Bürkle, A., Moreno‐Villanueva, M., Grune, T., Weber, D., Gonos, E. S., Friguet, B., Petropoulos, I., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10288-x · Cited by 4 · see citing works
Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein
Rothemund, F., Scherer, M., Schilling, E.-M., Schweininger, J., Muller, Y. A., & Stamminger, T. (2022) · Viruses · doi:10.3390/v14081626 · Cited by 4 · see citing works
Comprehensive bioinformatics analysis of human cytomegalovirus pathway genes in pan-cancer
Yan, T., Pang, X., Liang, B., Meng, Q., Wei, H., Li, W., Liu, D., & Hu, Y. (2024) · Human Genomics · doi:10.1186/s40246-024-00633-5 · Cited by 3 · see citing works
Bona, D. D., Pandey, J. P., Aiello, A., Bilancia, M., Candore, G., Caruso, C., Colomba, C., Duro, G., Ligotti, M. E., Macchia, L., et al. (2019) · Immunology · doi:10.1111/imm.13133 · Cited by 3 · see citing works
Self-citationHassan, F. F. A., Hamdan, M. B., & Melhem, N. M. (2019) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2019.0134 · Cited by 4 · see citing works
Ji, J., Zhuang, Y., Wang, H., Feng, C., Zhao, Y. X., & Zhang, X. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108014 · Cited by 3 · see citing works
(2021) · Frontiers research topics · doi:10.3389/978-2-88966-718-5 · Cited by 3 · see citing works
In vitro activity of novel 4-iminohydantoin sulfamide derivatives against human cytomegalovirus
Zhirnov, V. V., Shablykin, O. V., Chumachenko, S. A., Kornii, Y., Keith, K. A., Harden, E. A., Hartline, C. B., James, S. H., Kobzar, O. L., Kovalishyn, V., et al. (2023) · Chemical Papers · doi:10.1007/s11696-023-03038-1 · Cited by 2 · see citing works
Thomas, A., Smitha, T. V., Rao, K., Priya, N., Sheethal, H., & Chitra, S. (2023) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_2_23 · Cited by 1 · see citing works
Graham, L. V., Fisher, J. G., Doyle, A. D. P., Sale, B., Rio, L. D., French, A. J. E., Mayor, N. P., Turner, T. R., Marsh, S. G. E., Cragg, M. S., et al. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1404051 · Cited by 1 · see citing works
Immunogenetics: a tool for anthropological studies
Bhat, E. A., Khan, J., Ismai, R. M., & Sajjad, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90053-9.00008-7
Immunognetics: a tool for the identification of novel therapeutic targets in immune disorders
Maqbool, I., Ali, S. I., Paul, V. I., & Muzaffer, U. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90250-2.00015-7
Rocamora‐Reverte, L., Knoll, G., & Weinberger, B. (2025) · Springer eBooks · doi:10.1007/978-3-476-06005-1_56-1
Hsu, H.-T., Huang, C. Y., Hwang, Y., & Hsiao, C. (2026) · British Journal of Ophthalmology · doi:10.1136/bjo-2025-327910
- Authors
- Aiello, A., Accardi, G., Candore, G., Caruso, C., Colomba, C., Di Bona, D., Duro, G., Gambino, C. M., Ligotti, M. E., & Pandey, J. P.
- Affiliations
- University of Palermo (IT)
- Dipartimento dell’Emergenza e dei Trapianti d’Organo, Università di Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
- Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy (IT)
- Medical University of South Carolina (US)
- Corresponding author
- Caruso, Calogero
- ORCID
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-02-05
- Volume
- 20
- Issue
- 3
- Pages
- 685
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC6386818
- OpenAlex
- W2911416346
- Cited by
- 38
- References
- 58
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 2 · 2019: 4
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- human cytomegalovirus, immunogenetics, host-virus interaction, HLA, killer cell immunoglobulin-like receptors, Gm allotypes, immunosenescence, immunosuppressed transplant recipients, aging, humoral immunity, cell-mediated immunity, longevity
- MeSH terms
- Aging, Animals, Cytomegalovirus Infections, Cytomegalovirus, Genotype, HLA Antigens, Humans, Immunity, Cellular, Immunogenetics, Genetic Predisposition to Disease, Host-Pathogen Interactions, Immunity, Humoral
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review