Cited by 38Cytomegalovirus and herpesvirus researchImmune Cell Function and InteractionViral-associated cancers and disorders

Role of immunogenetics in the outcome of HCMV infection: implications for ageing

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Aiello, Anna, Accardi, Giulia, Candore, Giuseppina, Caruso, Calogero, Colomba, Claudia, Di Bona, Danilo, Duro, Giovanni, Gambino, Caterina Maria +2 more·2019·International Journal of Molecular Sciences

Abstract

The outcome of host-virus interactions is determined by a number of factors, some related to the virus, others to the host, such as environmental factors and genetic factors. Therefore, different individuals vary in their relative susceptibility to infections. Human cytomegalovirus (HCMV) is an important pathogen from a clinical point of view, as it causes significant morbidity and mortality in immunosuppressed or immunosenescent individuals, such as the transplanted patients and the elderly, respectively. It is, therefore, important to understand the mechanisms of virus infection control. In this review, we discuss recent advances in the immunobiology of HCMV-host interactions, with particular emphasis on the immunogenetic aspects (human leukocyte antigens, HLA; killer cell immunoglobulin-like receptors, KIRs; immunoglobulin genetic markers, GM allotypes) to elucidate the mechanisms underlying the complex host-virus interaction that determine various outcomes of HCMV infection. The results, which show the role of humoral and cellular immunity in the control of infection by HCMV, would be valuable in directing efforts to reduce HCMV spurred health complications in the transplanted patients and in the elderly, including immunosenescence. In addition, concerning GM allotypes, it is intriguing that, in a Southern Italian population, alleles associated with the risk of developing HCMV symptomatic infection are negatively associated with longevity.

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  1. [7]Roizman B. Pellet P.E. The Family Herpesviridae: A Brief Introduction Fields Virology Knipe D.M. Howley P.M. Raven Press New York, NY, USA 2001 2381 2397
  2. [34]Aiello A. Accardi G. Candore G. Gambino C.M. Caruso C. Di Bona D. The importance of interactions between KIRs and HLA ligands in the development of autoimmune and viral diseases Causality and Chance in Ageing, Age-Related Diseases and Longevity, Proceedings of the Symposium Updated in Pathobiology, Palermo, Italy, 24 March 2017 Caruso C. Accardi G. Unipapress Palermo, Italy 2017 91 110

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Authors
Aiello, A., Accardi, G., Candore, G., Caruso, C., Colomba, C., Di Bona, D., Duro, G., Gambino, C. M., Ligotti, M. E., & Pandey, J. P.
Affiliations
  • University of Palermo (IT)
  • Dipartimento dell’Emergenza e dei Trapianti d’Organo, Università di Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
  • Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy (IT)
  • Medical University of South Carolina (US)
Corresponding author
Caruso, Calogero
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-02-05
Volume
20
Issue
3
Pages
685
ISSN
1422-0067 (ISSN-L)
OpenAlex
W2911416346
Cited by
38
References
58
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 2 · 2019: 4
FWCI
0.91
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion, other-oa)
Funders
Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN)
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
human cytomegalovirus, immunogenetics, host-virus interaction, HLA, killer cell immunoglobulin-like receptors, Gm allotypes, immunosenescence, immunosuppressed transplant recipients, aging, humoral immunity, cell-mediated immunity, longevity
MeSH terms
Aging, Animals, Cytomegalovirus Infections, Cytomegalovirus, Genotype, HLA Antigens, Humans, Immunity, Cellular, Immunogenetics, Genetic Predisposition to Disease, Host-Pathogen Interactions, Immunity, Humoral

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