Immune-inflammatory responses in the elderly: an update
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Production of senescence-associated secretory phenotype (SASP) is an important feature of immunosenescence.
“T cell–output decline is an important feature of immunosenescence as well as the production of senescence-associated secretory phenotype, increased glycolysis, and reactive oxygen species.”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [15]
Several factors, such as genetics, nutrition, exercise, previous exposure to microorganisms, biological and cultural sex, and HCMV status, can influence immunosenescence.
“Several factors, such as genetics, nutrition, exercise, previous exposure to microorganisms, biological and cultural sex, and human cytomegalovirus (HCMV) status can influence immunosenescence (3, 6–11).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [9]
The long-term chronic microbial burden induces progressive activation of macrophages, hence contributing to the chronic state of low-grade inflammation, inflamm-aging, another hallmark of immunosenescence.
“In addition, the long-term chronic microbial burden induces progressive activation of macrophages, hence contributing to the chronic state of low-grade inflammation, inflamm-aging, another hallmark of immunosenescence (3, 9, 57).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [9]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
O’Toole, P. W., & Jeffery, I. B. (2015) · Science · doi:10.1126/science.aac8469 · Cited by 1,202 · see citing works
Inflammation and cancer: advances and new agents
Crusz, S. M., & Balkwill, F. R. (2015) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2015.105 · Cited by 1,184 · see citing works
Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.012 · Cited by 850 · see citing works
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · cited 2× · see citing works
“In October 2013, a group of experts in biology and genetics of ageing developed a consensus related to the discovery and development of safe interventions to slow aging and increase healthy lifespan in humans [27].”
Self-citationThe Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
Balistreri, C. R., Caruso, C., & Candore, G. (2010) · Mediators of Inflammation · doi:10.1155/2010/802078 · Cited by 554 · see citing works
Self-citationWei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., Groshen, S., Mack, W. J., Guen, E., Di Biase, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aai8700 · Cited by 553 · see citing works
Cheng, C., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., Sacco, S. D., Mirisola, M. G., Quinn, D. I., Dorff, T. B., et al. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.04.014 · Cited by 484 · see citing works
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453 · see citing works
Fontana, L., Weiss, E. P., Villareal, D. T., Klein, S., & Holloszy, J. O. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00417.x · Cited by 396 · see citing works
How ageing processes influence cancer
de Magalhães, J. P. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3497 · Cited by 367 · see citing works
DAMPs as mediators of sterile inflammation in aging-related pathologies
Feldman, N., Rotter-Maskowitz, A., & Okun, E. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.003 · Cited by 283 · see citing works
Hallmarks of human “immunosenescence”: adaptation or dysregulation?
Pawelec, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-15 · Cited by 257 · see citing works
Ageing: from inflammation to cancer
Leonardi, G. C., Accardi, G., Monastero, R., Nicoletti, F., & Libra, M. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0112-5 · Cited by 241 · cited 2× · see citing works
“The “dietary inflammatory index” (DII) weights each major macronutrient and multiple micronutrients on the basis of their general pro-inflammatory effects, as measured, for example, by assessment of CRP in serum [17, 18].”
Self-citationAdvances in Geroscience: Impact on Healthspan and Chronic Disease
Burch, J. B., Augustine, A. D., Frieden, L. A., Hadley, E., Howcroft, T. K., Johnson, R. L., Khalsa, P. S., Kohanski, R. A., Li, X. L., Macchiarini, F., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu041 · Cited by 209 · see citing works
Vaccines for the elderly: current use and future challenges
Weinberger, B. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0107-2 · Cited by 164 · see citing works
Candore, G., Caruso, C., Jirillo, E., Magrone, T., & Vasto, S. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883868 · Cited by 140 · see citing works
Self-citationCytokine production pathway in the elderly
Caruso, C., Candore, G., Cigna, D., Lorenzo, G. D., Sireci, G., Dieli, F., & Salerno, A. (1996) · Immunologic Research · doi:10.1007/bf02918286 · Cited by 137 · see citing works
Self-citationInflammation, ageing and cancer
Vasto, S., Carruba, G., Lio, D., Colonna‐Romano, G., Bona, D. D., Candore, G., & Caruso, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.06.003 · Cited by 134 · see citing works
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Caruso, C., Accardi, G., Virruso, C., & Candore, G. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-20 · Cited by 92 · see citing works
Self-citationBucci, L., Ostan, R., Cevenini, E., Pini, E., Scurti, M., Vitale, G., Mari, D., Caruso, C., Sansoni, P., Fanelli, F., et al. (2016) · Aging · doi:10.18632/aging.100912 · Cited by 71 · see citing works
Self-citationAvery, P. J., Barzilai, N., Bénétos, A., Bilianou, H. I., Capri, M., Caruso, C., Franceschi, C., Katsiki, N., Mikhailidis, D. P., Panotopoulos, G., et al. (2014) · Current Vascular Pharmacology · doi:10.2174/1570161111666131219101226 · Cited by 56 · see citing works
Self-citationVentura, M. T., Scichilone, N., Paganelli, R., Minciullo, P. L., Patella, V., Bonini, M., Passalacqua, G., Lombardi, C., Simioni, L., Ridolo, E., et al. (2017) · Clinical and Molecular Allergy · doi:10.1186/s12948-017-0059-2 · Cited by 56 · see citing works
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Aiello, A., Accardi, G., Candore, G., Gambino, C. M., Mirisola, M. G., Taormina, G., Virruso, C., & Caruso, C. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1294684 · Cited by 52 · see citing works
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Vasto, S., & Caruso, C. (2004) · Immunity & Ageing · doi:10.1186/1742-4933-1-1 · Cited by 40 · see citing works
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Aspinall, R., & Lang, P. O. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0111-6 · Cited by 38 · see citing works
Lorenzo, G. D., Bona, D. D., Belluzzo, F., & Macchia, L. (2017) · Immunity & Ageing · doi:10.1186/s12979-017-0105-4 · Cited by 24 · see citing works
Pellicanò, M., Buffa, S., Goldeck, D., Bulati, M., Martorana, A., Caruso, C., Colonna‐Romano, G., & Pawelec, G. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt120 · Cited by 22 · see citing works
Self-citationCaruso, C., & Vasto, S. (2016) · Encyclopedia of Immunobiology · doi:10.1016/b978-0-12-374279-7.19003-4 · Cited by 18 · see citing works
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Caruso, C., & Accardi, G. (2017) · Cited by 11 · see citing works
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Accardi, G., Caruso, C., & Grillari, J. (2017) · Nova Science Publishers (Nova Science Publishers, Inc.) · Cited by 2 · see citing works
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Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
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Aiello, A., Accardi, G., Candore, G., Caruso, C., Colomba, C., Di Bona, D., Duro, G., Gambino, C. M., Ligotti, M. E., & Pandey, J. P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030685 · Cited by 38 · see citing works
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- Authors
- Accardi, G., & Caruso, C.
- Affiliations
- University of Palermo (IT)
- Corresponding author
- Caruso, Calogero
- Venue
- Immunity & Ageing
- Published
- 2018-03-02
- Volume
- 15
- Issue
- 1
- Pages
- 11-11
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC5833087
- OpenAlex
- W2791222633
- Cited by
- 102
- References
- 34
- Citations by year
- 2026: 5 · 2025: 18 · 2024: 16 · 2023: 14 · 2022: 5 · 2021: 11 · 2020: 11 · 2019: 18 · 2018: 4
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- immune-inflammatory response, aging, older adults, inflammation, immunosenescence
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