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Cited by 331

The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.

Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis

Open access
Baj, Andreina, Moro, Elisabetta, Bistoletti, Michela, Orlandi, Viviana, Crema, Francesca, Giaroni, Cristina·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20061482
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Abstract

A complex bidirectional communication system exists between the gastrointestinal tract and the brain. Initially termed the “gut-brain axis” it is now renamed the “microbiota-gut-brain axis” considering the pivotal role of gut microbiota in maintaining local and systemic homeostasis. Different cellular and molecular pathways act along this axis and strong attention is paid to neuroactive molecules (neurotransmitters, i.e., noradrenaline, dopamine, serotonin, gamma aminobutyric acid and glutamate and metabolites, i.e., tryptophan metabolites), sustaining a possible interkingdom communication system between eukaryota and prokaryota. This review provides a description of the most up-to-date evidence on glutamate as a neurotransmitter/neuromodulator in this bidirectional communication axis. Modulation of glutamatergic receptor activity along the microbiota-gut-brain axis may influence gut (i.e., taste, visceral sensitivity and motility) and brain functions (stress response, mood and behavior) and alterations of glutamatergic transmission may participate to the pathogenesis of local and brain disorders. In this latter context, we will focus on two major gut disorders, such as irritable bowel syndrome and inflammatory bowel disease, both characterized by psychiatric co-morbidity. Research in this area opens the possibility to target glutamatergic neurotransmission, either pharmacologically or by the use of probiotics producing neuroactive molecules, as a therapeutic approach for the treatment of gastrointestinal and related psychiatric disorders.

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Metadata

Authors
Baj, A., Moro, E., Bistoletti, M., Orlandi, V., Crema, F., & Giaroni, C.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-03-25
Volume
20
Issue
6
Pages
1482
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20061482
OpenAlex
W2922938215
Cited by
331
References
269
FWCI
9.74
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis. https://app.cochat.ai/papers/10.3390/ijms20061482
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Baj, A., Moro, E., Bistoletti, M., Orlandi, V., Crema, F., & Giaroni, C. (2019). Glutamatergic Signaling Along The Microbiota-Gut-Brain Axis. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20061482

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