The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance
Open accessAbstract
Multiple drug-resistant bacteria are a severe and growing public health concern. Because relatively few antibiotics have been approved over recent years and because of the inability of existing antibiotics to combat bacterial infections fully, demand for unconventional biocides is intense. Metallic nanoparticles (NPs) offer a novel potential means of fighting bacteria. Although metallic NPs exert their effects through membrane protein damage, superoxide radicals and the generation of ions that interfere with the cell granules leading to the formation of condensed particles, their antimicrobial potential, and mechanisms of action are still debated. This article discusses the action of metallic NPs as antibacterial agents, their mechanism of action, and their effect on bacterial drug resistance. Based on encouraging data about the antibacterial effects of NP/antibiotic combinations, we propose that this concept be thoroughly researched to identify means of combating drug-resistant bacteria.
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Cites
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Cited by
Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens
More, P. R., Pandit, S., Filippis, A. D., Franci, G., Mijakovic, I., & Galdiero, M. (2023) · Microorganisms · doi:10.3390/microorganisms11020369 · Cited by 745
Bahrulolum, H., Nooraei, S., Javanshir, N., Tarrahimofrad, H., Mirbagheri, V. S., Easton, A. J., & Ahmadian, G. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00834-3 · Cited by 677
Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications
Yaqoob, S. B., Adnan, R., Rameez Khan, R. M., & Rashid, M. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00376 · Cited by 308
Maghimaa, M., & Alharbi, S. A. (2020) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/j.jphotobiol.2020.111806 · Cited by 253
Metadata
- Authors
- Shaikh, S., Nazam, N., Rizvi, S. M. D., Ahmad, K., Baig, M. H., Lee, E. J., & Choi, I.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2019-05-18
- Volume
- 20
- Issue
- 10
- Pages
- 2468
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2946291652
- Cited by
- 507
- References
- 75
- FWCI
- 19.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shaikh, S., Nazam, N., Rizvi, S. M. D., Ahmad, K., Baig, M. H., Lee, E. J., & Choi, I. (2019). Mechanistic Insights into the Antimicrobial Actions of Metallic Nanoparticles and Their Implications for Multidrug Resistance. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20102468
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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