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Cited by 428

The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.

New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment

Open access
Chen, Shang-Hung, Chang, Jang-Yang·2019·International Journal of Molecular Sciences
DOI 10.3390/ijms20174136
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Abstract

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various types of cancer for decades, drug resistance has been a major clinical impediment. In general, cisplatin exerts cytotoxic effects in tumor cells mainly through the generation of DNA-platinum adducts and subsequent DNA damage response. Accordingly, considerable effort has been devoted to clarify the resistance mechanisms inside tumor cells, such as decreased drug accumulation, enhanced detoxification activity, promotion of DNA repair capacity, and inactivated cell death signaling. However, recent advances in high-throughput techniques, cell culture platforms, animal models, and analytic methods have also demonstrated that the tumor microenvironment plays a key role in the development of cisplatin resistance. Recent clinical successes in combination treatments with cisplatin and novel agents targeting components in the tumor microenvironment, such as angiogenesis and immune cells, have also supported the therapeutic value of these components in cisplatin resistance. In this review, we summarize resistance mechanisms with respect to a single tumor cell and crucial components in the tumor microenvironment, particularly focusing on favorable results from clinical studies. By compiling emerging evidence from preclinical and clinical studies, this review may provide insights into the development of a novel approach to overcome cisplatin resistance.

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Metadata

Authors
Chen, S.-H., & Chang, J.-Y.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2019-08-24
Volume
20
Issue
17
Pages
4136
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms20174136
OpenAlex
W2969669884
Cited by
428
References
97
FWCI
15.96
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. https://app.cochat.ai/papers/10.3390/ijms20174136
The paper
Chen, S.-H., & Chang, J.-Y. (2019). New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms20174136

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.