Cited by 411Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 122 of the 126 references it cites were found in a registry or an index.

Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications

Open access

Zorena, Katarzyna, Jachimowicz-Duda, Olga, Ślęzak, Daniel, Robakowska, Marlena, Mrugacz, Małgorzata·2020·International Journal of Molecular Sciences

DOI 10.3390/ijms21103570PMC PMC7278967

Open this paper in CoChat — free account Open PDF

Abstract

The World Health Organization (WHO) has recognized obesity as one of the top ten threats to human health. It is estimated that the number of obese and overweight people worldwide exceeds the number of those who are undernourished. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of increased release of biologically active adipokines. Adipokines released into the circulating blood, due to their specific receptors on the surface of target cells, act as classic hormones affecting the metabolism of tissues and organs. What is more, adipokines and cytokines may decrease the insulin sensitivity of tissues and induce inflammation and development of chronic complications. Certainly, it can be stated that in an era of a global obesity pandemic, adipokines may gain more and more importance as regards their use in the diagnostic evaluation and treatment of diseases. An extensive search for materials on the role of white, brown and perivascular fatty tissue and obesity-related metabolic and chronic complications was conducted online using PubMed, the Cochrane database and Embase.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms21103570

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Untitled work
(2000) · PubMed · Cited by 13,173
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation
Bray, G. A., Kim, K. K., Wilding, J. P. H., & on behalf of the World Obesity Federation (2017) · Obesity Reviews · doi:10.1111/obr.12551 · Cited by 1,612
Angiogenesis and Inflammation in Peritoneal Dialysis: The Role of Adipocytes
Shi, J., Yu, M., & Sheng, M. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000476017 · Cited by 1,406
Resistin Is an Inflammatory Marker of Atherosclerosis in Humans
Reilly, M. P., Lehrke, M., Wolfe, M. L., Rohatgi, A. K., Lazar, M. A., & Rader, D. J. (2005) · Circulation · doi:10.1161/01.cir.0000155620.10387.43 · Cited by 915
Brown adipose tissue as a secretory organ
Villarroya, F., Cereijo, R., Villarroya, J., & Giralt, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.136 · Cited by 697
Elevated Plasma Level of Visfatin/Pre-B Cell Colony-Enhancing Factor in Patients with Type 2 Diabetes Mellitus
Chen, M., Chung, F., Chang, D., Tsai, J. C. ‐., Huang, H.-F., Shin, S., & Lee, Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1475 · Cited by 660
Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages
Kumada, M., Kihara, S., Ouchi, N., Kobayashi, H., Okamoto, Y., Ohashi, K., Maeda, K., Nagaretani, H., Kishida, K., Maeda, N., et al. (2004) · Circulation · doi:10.1161/01.cir.0000127953.98131.ed · Cited by 555
Insulin resistance associated to obesity: the link TNF-alpha
Nieto-Vázquez, I., Fernández‐Veledo, S., Kramer, D., Vila‐Bedmar, R., García‐Guerra, L., & Lorenzo, M. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802181047 · Cited by 493
The current biology of resistin
Steppan, C. M., & Lazar, M. A. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01306.x · Cited by 371
Prevalence of Severe Obesity among Primary School Children in 21 European Countries
Spinelli, A., Buoncristiano, M., Kovacs, V. A., Yngve, A., Spiroski, I. M., Obreja, G., Starc, G., Pérez‐Farinós, N., Rito, A. I., Kunešová, M., et al. (2019) · Obesity Facts · doi:10.1159/000500436 · Cited by 371
Relevance of Leptin and Other Adipokines in Obesity-Associated Cardiovascular Risk
Landecho, M. F., Tuero, C., Valentí, V., Bilbao, I., de la Higuera, M., & Frühbeck, G. (2019) · Nutrients · doi:10.3390/nu11112664 · Cited by 313
Role of leptin as a link between metabolism and the immune system
Pérez‐Pérez, A., Vilariño‐García, T., Riejos, P. F., Martín-González, J., Segura-Egea, J. J., & Sánchez‐Margalet, V. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.03.001 · Cited by 283
Novel trends in development of dietary fiber rich meat products—a critical review
Mehta, N., Ahlawat, S. S., Sharma, D. P., & Dabur, R. S. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-013-1010-2 · Cited by 268
Characterisation of UK diets according to degree of food processing and associations with socio-demographics and obesity: cross-sectional analysis of UK National Diet and Nutrition Survey (2008–12)
Adams, J. M., & White, M. J. (2015) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-015-0317-y · Cited by 266
The Relationship of Body Mass and Fat Distribution With Incident Hypertension
Chandra, A., Neeland, I. J., Berry, J. D., Ayers, C. R., Rohatgi, A., Das, S. R., Khera, A., McGuire, D. K., de Lemos, J. A., & Turer, A. T. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.05.057 · Cited by 264
The inflammatory status score including IL-6, TNF-α, osteopontin, fractalkine, MCP-1 and adiponectin underlies whole-body insulin resistance and hyperglycemia in type 2 diabetes mellitus
Daniele, G., Guardado‐Mendoza, R., Winnier, D. A., Fiorentino, T. V., Zuo, P., Cornell, J. E., Andreozzi, F., Jenkinson, C. P., Cersósimo, E., Federici, M., et al. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0543-1 · Cited by 252
Adipose tissue plasticity from WAT to BAT and in between
Lee, Y., Mottillo, E. P., & Granneman, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.011 · Cited by 236
Adipokines, diabetes and atherosclerosis: an inflammatory association
Freitas‐Lima, L. C., Braga, V. A., de França-Silva, M. D. S., Cruz, J. C., Santos, S. H. S., Monteiro, M. M. D. O., & Balarini, C. M. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00304 · Cited by 218
Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications
Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 211
Health impacts of obesity
Djalalinia, S., Qorbani, M., Peykari, N., & Kelishadi, R. (2014) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.311.7033 · Cited by 209
Adipose Organ Development and Remodeling
Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 197
Prevalence of peripheral neuropathy in patients with diabetes: A systematic review and meta-analysis
Sun, J., Wang, Y., Zhang, X., Zhu, S., & He, H. G. (2020) · Primary care diabetes · doi:10.1016/j.pcd.2019.12.005 · Cited by 196
Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs
Lee, M.-W., Lee, M., & Oh, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060854 · Cited by 192
Role of resistin in inflammation and inflammation-related diseases.
Pang, S. S., & Le, Y. Y. (2006) · PubMed · Cited by 189
Adipose Tissue as an Endocrine Organ: An Update on Pro-inflammatory and Anti-inflammatory Microenvironment
Smitka, K., & Maresova, D. (2015) · Prague Medical Report · doi:10.14712/23362936.2015.49 · Cited by 178
Chemerin Isoforms and Activity in Obesity
Buechler, C., Feder, S., Haberl, E. M., & Aslanidis, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051128 · Cited by 170
Control of Adipocyte Differentiation in Different Fat Depots; Implications for Pathophysiology or Therapy
Ma, X., Lee, P., Chisholm, D. J., & James, D. E. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00001 · Cited by 167
New Perspective in Diabetic Neuropathy: From the Periphery to the Brain, a Call for Early Detection, and Precision Medicine
Yang, H., SLOAN, G. P., Ye, Y., Wang, S., Duan, B., Tesfaye, S. H., & Gao, L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00929 · Cited by 164
Increased Chemerin and Decreased Omentin-1 in Both Adipose Tissue and Plasma in Nascent Metabolic Syndrome
Jialal, I., Devaraj, S., Kaur, H., ADAMS-HUET, B. A., & Bremer, A. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3673 · Cited by 155
The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects
Froy, O., & Garaulet, M. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00193 · Cited by 155
Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes
Tuttolomondo, A. (2015) · World Journal of Orthopedics · doi:10.5312/wjo.v6.i1.62 · Cited by 151
Psoriasis, metabolic syndrome and cardiovascular risk factors. A population‐based study
Armenteros, J. M. F., Gómez‐Arbonés, X., Butı́, M., Bars, À. B., Sanmartín-Novell, V., Ortega, M., Martínez‐Alonso, M., Garí, E., Portero‐Otín, M., Santamaria‐Babí, L. F., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15159 · Cited by 151
Adipose tissue browning in mice and humans
Herz, C. T., & Kiefer, F. W. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0598 · Cited by 144
Vascular Effects of Novel Adipocytokines: Focus on Vascular Contractility and Inflammatory Responses
Yamawaki, H. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.307 · Cited by 142
Identification of Adipokine Clusters Related to Parameters of Fat Mass, Insulin Sensitivity and Inflammation
Flehmig, G., Scholz, M. R., Klöting, N., Faßhauer, M., Tönjes, A., Stümvoll, M., Youn, B., & Blüher, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099785 · Cited by 140
Pink Adipocytes
Cinti, S. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.05.007 · Cited by 134
Adiponectin as a potential biomarker of vascular disease
Mohammadi, S., Arefhosseini, S. R., Ebrahimi‐Mameghani, M., Fallah, P., & Bazi, Z. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s48753 · Cited by 129
Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease
EL-Mesallamy, H. O., El-Derany, M. O., & Hamdy, N. Μ. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03353.x · Cited by 129
Circulating adipokine levels in Portuguese patients with psoriasis vulgaris according to body mass index, severity and therapy
Coimbra, S., Oliveira, H., Reis, F., Belo, L., Rocha, S., Quintanilha, A. T., Figueiredo, A., Teixeira, F. J., Castro, E. M. B., Rocha‐Pereira, P., et al. (2010) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2010.03647.x · Cited by 125
Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice
Guan, X.-M., Yu, H., & der Ploeg, L. H. T. V. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00150-8 · Cited by 122
Analysis of Inflammatory Mediators in Type 2 Diabetes Patients
Al-Shukaili, A. K., Al-Ghafri, S., Al-Marhoobi, S., Al-Abri, S., Al‐Lawati, J., & Al-Maskari, M. Y. (2013) · International Journal of Endocrinology · doi:10.1155/2013/976810 · Cited by 118
What is the real cost of our food? Implications for the environment, society and public health nutrition
O’Kane, G. (2011) · Public Health Nutrition · doi:10.1017/s136898001100142x · Cited by 107
Patterns of Obesity Development before the Diagnosis of Type 2 Diabetes: The Whitehall II Cohort Study
Vistisen, D., Witte, D. R., Tabák, Á. G., Herder, C., Brunner, E. J., Mika Kivimaki, B., & Færch, K. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001602 · Cited by 106
Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential
Zha, D., Wu, X., & Gao, P. H. (2017) · Endocrinology · doi:10.1210/en.2016-1765 · Cited by 102
IL-34 Is Associated with Obesity, Chronic Inflammation, and Insulin Resistance
Chang, E., Lee, S. K., Song, Y. S., Jang, Y. J., Park, H. S., Hong, J. P., Ko, A., Kim, D. Y., Kim, J.-H., Lee, Y. J., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4409 · Cited by 101
The relationship of visfatin/pre–B-cell colony-enhancing factor/nicotinamide phosphoribosyltransferase in adipose tissue with inflammation, insulin resistance, and plasma lipids
Chang, Y., Chang, T., Lee, W., & Chuang, L. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.011 · Cited by 98
Serum vaspin levels in type 2 diabetic women in relation to microvascular complications
Gülçelik, N. E., Karakaya, J., Gedik, A. A., Usman, A., & Gürlek, A. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0723 · Cited by 98
The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression
Corrêa, L. H., Cardoso, G. S. H. R., & Magalhães, K. G. (2019) · Cells · doi:10.3390/cells8070662 · Cited by 98
Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus
Uslu, S., Kebapçı, N., Kara, M., & Bal, C. (2012) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2012.557 · Cited by 96
Serum Leptin, Resistin, and Adiponectin Concentrations in Psoriasis: A Meta-Analysis of Observational Studies
Kyriakou, A. E., Patsatsi, A., Sotiriadis, D., & Goulis, D. G. (2017) · Dermatology · doi:10.1159/000481882 · Cited by 96
Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1β on white adipocyte browning
Okla, M., Zaher, W., Alfayez, M., & Chung, S. (2018) · Inflammation · doi:10.1007/s10753-017-0718-y · Cited by 96
Potential Biomarkers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease
Ikmal, S. I. Q. S., Huri, H. Z., Vethakkan, S. R., & Ahmad, W. A. W. (2013) · International Journal of Endocrinology · doi:10.1155/2013/698567 · Cited by 93
Lipoprotein(a) in Cardiovascular Diseases
Malaguarnera, M., Vacante, M., Russo, C., Malaguarnera, G., Antic, T., Malaguarnera, L., Bella, R., Pennisi, G., Galvano, F., & Frigiola, A. (2012) · BioMed Research International · doi:10.1155/2013/650989 · Cited by 88
The geographic distribution of obesity in the US and the potential regional differences in misreporting of obesity
Le, A. T.-K., Judd, S. E., Allison, D. B., Oza‐Frank, R. B., Affuso, O., Safford, M. M., Howard, V. J., & Howard, G. (2013) · Obesity · doi:10.1002/oby.20451 · Cited by 85
The effect of sugar and processed food imports on the prevalence of overweight and obesity in 172 countries
Lin, T. K., Teymourian, Y., & Tursini, M. S. (2018) · Globalization and Health · doi:10.1186/s12992-018-0344-y · Cited by 83
Prevention of Childhood Obesity
Koletzko, B. V., Fishbein, M. H., Lee, W. S., Moreno, L. A., Mouane, N., Mouzaki, M., & Verduci, E. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002708 · Cited by 82
Short-Term Physiological Effects of a Very Low-Calorie Ketogenic Diet: Effects on Adiponectin Levels and Inflammatory States
Monda, V., Polito, R., Lovino, A. R., Finaldi, A., Valenzano, A. A., Nigro, E., Corso, G., Sessa, F., Asmundo, A., Nunno, N. R. D., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093228 · Cited by 81
Adiponectin, resistin and IL-6 plasma levels in subjects with diabetic foot and possible correlations with clinical variables and cardiovascular co-morbidity
Tuttolomondo, A., Placa, S. L., Raimondo, D. D., Bellia, C., Caruso, A., Sasso, B. L., Guercio, G., Diana, G., Ciaccio, M., Licata, G., et al. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-50 · Cited by 80
Comparison of waist circumference using the World Health Organization and National Institutes of Health protocols.
Patry-Parisien, J., Shields, M. E., & Bryan, S. N. (2012) · PubMed · Cited by 77
Biomarkers of Inflammation in Obesity-Psoriatic Patients
Rodríguez‐Cerdeira, C., Cordeiro-Rodríguez, M., Carnero-Gregorio, M., López-Bárcenas, A., Martínez-Herrera, E. O., Fabbrocini, G., Sinani, A., Arenas, R., & González-Cespón, J. L. (2019) · Mediators of Inflammation · doi:10.1155/2019/7353420 · Cited by 75
Neurodegeneration and Neuroinflammation in Diabetic Retinopathy: Potential Approaches to Delay Neuronal Loss
ubowska, J. K., Malaguarnera, L., Wąż, P., & Zorena, K. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160614095559 · Cited by 71
Self-citation
Predicting waist circumference from body mass index
Bozeman, S. R., Hoaglin, D. C., Burton, T. M., Pashos, C. L., Ben-Joseph, R. H., & Hollenbeak, C. S. (2012) · BMC Medical Research Methodology · doi:10.1186/1471-2288-12-115 · Cited by 68
Adipose tissue inflammation: Feeding the development of type 2 diabetes mellitus
Richardson, V. R., Smith, K. A., & Carter, A. M. (2013) · Immunobiology · doi:10.1016/j.imbio.2013.05.002 · Cited by 65
TNF-α reduces g0s2 expression and stimulates lipolysis through PPAR-γ inhibition in 3T3-L1 adipocytes
Jin, D., Sun, J., Huang, J., He, Y., An, Y., Yu, X., & Yang, Z. (2014) · Cytokine · doi:10.1016/j.cyto.2014.06.005 · Cited by 63
Proinflammatory Cytokines, Adiponectin, and Increased Risk of Primary Cardiovascular Events in Diabetic Patients With or Without Renal Dysfunction
Schöttker, B., Herder, C., Rothenbacher, D., Roden, M., Kolb, H., Müller, H., & Brenner, H. (2013) · Diabetes Care · doi:10.2337/dc12-1416 · Cited by 63
Association between serum adipocytokine levels and microangiopathies in patients with type 2 diabetes mellitus
Jung, C., Kim, B., Mok, J., Kang, S., & Kim, C. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12144 · Cited by 61
Inflammation, Haemostatic Disturbance, and Obesity: Possible Link to Pathogenesis of Diabetic Retinopathy in Type 2 Diabetes
Tomić, M., Ljubić, S., Kaštelan, S., Antunica, A. G., Jazbec, A., & Poljičanin, T. (2013) · Mediators of Inflammation · doi:10.1155/2013/818671 · Cited by 61
Role of adipocytokines in predicting the development of diabetes and its late complications
Gülçelik, N. E., Usman, A., & Gürlek, A. (2009) · Endocrine · doi:10.1007/s12020-009-9234-7 · Cited by 60
Sympathovagal Imbalance Contributes to Prehypertension Status and Cardiovascular Risks Attributed by Insulin Resistance, Inflammation, Dyslipidemia and Oxidative Stress in First Degree Relatives of Type 2 Diabetics
Pal, G. K., Adithan, C., Ananthanarayanan, P. H., Pal, P., Nanda, N., Durgadevi, T., Lalitha, V., Syamsunder, A. N., & Dutta, T. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078072 · Cited by 58
The discriminative ability of waist circumference, body mass index and waist-to-hip ratio in identifying metabolic syndrome: Variations by age, sex and race
Kee, C. C., Ghazali, S. M., Lim, K. H., Subenthiran, S., Huey, T. C., Kuay, L. K., Mustapha, F. I., Yusoff, A. F., & Mustafa, A. N. (2015) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2015.02.006 · Cited by 56
Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes
Tews, D., Pula, T., Funcke, J., Jastroch, M., Keuper, M., Debatin, K., Wabitsch, M., & Fischer‐Posovszky, P. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101286 · Cited by 54
Microvascular complications and risk factors in patients with type 2 diabetes
Gómez, F. J., Fernández, C., Ruiz, I. M., Pérez-Jáuregui, C. D. G., Rodríguez, B. S., Gonzalez‐Losada, T., & Galindo, A. S. (2011) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2011.01.006 · Cited by 53
Plasma adiponectin, IL-6, hsCRP, and TNF-α levels in subject with diabetic foot and their correlation with clinical variables in a North Indian tertiary care hospital
Ahmad, J., Zubair, M., & Malik, A. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.100672 · Cited by 51
Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes
Morioka, T., Emoto, M., Yamazaki, Y., Kawano, N., Imamura, S., Numaguchi, R., Urata, H., Motoyama, K., Mori, K., Fukumoto, S., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-10 · Cited by 50
Prevalence of polymorphisms in OPG, RANKL and RANK as potential markers for Charcot arthropathy development
Bruhn‐Olszewska, B., Korzon-Burakowska, A., Węgrzyn, G., & Jakóbkiewicz‐Banecka, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-00563-4 · Cited by 50
Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation
Malin, S. K., Kirwan, J. P., Sia, C. L., & González, F. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00510.2014 · Cited by 49
C-reactive protein levels in patients at cardiovascular risk: EURIKA study
Halcox, J., Roy, C., Tubach, F., Banegas, J. R., Dallongeville, J., Backer, G. D., Güallar, E., Sazova, O., Medina, J., Perk, J., et al. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-25 · Cited by 47
Annexins in Adipose Tissue: Novel Players in Obesity
Grewal, T., Enrich, C., Rentero, C., & Buechler, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143449 · Cited by 46
Adipose tissue dysfunction and metabolic disorders: Is it possible to predict who will develop type 2 diabetes mellitus? Role of markErs in the progreSsion of dIabeteS in obese paTIeNts (The RESISTIN trial)
Derosa, G., Catena, G., Gaudio, G. V., D’Angelo, A., & Maffioli, P. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154947 · Cited by 42
Obesity and mortality: are the risks declining? Evidence from multiple prospective studies in the United States
Mehta, T. S., Fontaine, K. R., Keith, S. W., Bangalore, S. S., Campos, G. D. L., Bartolucci, A., Pajewski, N. M., & Allison, D. B. (2014) · Obesity Reviews · doi:10.1111/obr.12191 · Cited by 41
Association between hyperleptinemia and oxidative stress in obese diabetic subjects
Pandey, G., Shihabudeen, M., David, H. P., Thirumurugan, E., & Thirumurugan, K. (2015) · Journal of Diabetes and Metabolic Disorders · doi:10.1186/s40200-015-0159-9 · Cited by 40
The G-308A Promoter Variant of the Tumor Necrosis Factor-α Gene Is Associated With Hypertension in Adolescents Harboring the Metabolic Syndrome
Sookoian, S., GARCIA, S., Gianotti, T. F., Dieuzeide, G., González, C. D., & Pirola, C. J. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.04.014 · Cited by 37
Adipokines as atherothrombotic risk factors in obese subjects: Associations with haemostatic markers and common carotid wall thickness
Csongrádi, É., Káplár, M., Nagy, B., Koch, C. A., Juhász, A., Bajnok, L., Varga, Z., Seres, I., Karányi, Z., Magyar, M. T., et al. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.02.007 · Cited by 35
The cut-off value for interleukin 34 as an additional potential inflammatory biomarker for the prediction of the risk of diabetic complications
Zorena, K., Jachimowicz-Duda, O., & Wąż, P. (2016) · Biomarkers · doi:10.3109/1354750x.2016.1138321 · Cited by 33
Self-citation
Effect of Body Weight on Metabolic Hormones and Fatty Acid Metabolism in Follicular Fluid of Women Undergoing In Vitro Fertilization: A Pilot Study
Nemer, L. B., Shi, H., Carr, B. R., Word, R. A., & Bükülmez, O. (2018) · Reproductive Sciences · doi:10.1177/1933719118776787 · Cited by 33
Sensitivity and Specificity Improvement in Abdominal Obesity Diagnosis Using Cluster Analysis during Waist Circumference Cut-Off Point Selection
Bermúdez, V., Rojas, J., Salazar, J. J., Áñez, R., Toledo, A., Bello, L., Apruzzese, V., González, R., Chacín, M., Cabrera, M., et al. (2015) · Journal of Diabetes Research · doi:10.1155/2015/750265 · Cited by 31
The Main Determinants of Serum Resistin Level in Type 2 Diabetic Patients are Renal Function and Inflammation not Presence of Microvascular Complication, Obesity and Insulin Resistance
Cebeci, E., Çakan, C., Gürsu, M., Uzun, S., Karadağ, S., Koldaş, M., Çalhan, T., Helvacı, Ş. A., & Öztürk, S. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-121262 · Cited by 30
Adipocytokine Involvement in Innate Immune Mechanisms
Żelechowska, P., Kozłowska, E., Pastwińska, J., Agier, J., & Brzezińska‐Błaszczyk, E. (2018) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0102 · Cited by 28
Cold‐Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity
Mihalopoulos, N. L., Yap, J. T., Beardmore, B. E., Holubkov, R., Nanjee, M. N., & Hoffman, J. M. (2020) · Obesity · doi:10.1002/oby.22767 · Cited by 26
Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)
O’Doherty, M. G., Jørgensen, T., Borglykke, A., Brenner, H., Schöttker, B., Wilsgaard, T., Siganos, G., Kavousi, M., Hughes, M., Müezzinler, A., et al. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9954-8 · Cited by 25
The Comparative Effect of Pioglitazone and Metformin on Serum Osteoprotegerin, Adiponectin and Intercellular Adhesion Molecule Concentrations in Patients with Newly Diagnosed Type 2 Diabetes: a Randomized Clinical Trial
Esteghamati, A., Azizi, R., Ebadi, M., Noshad, S., Mousavizadeh, M., Afarideh, M., & Nakhjavani, M. (2015) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0034-1396864 · Cited by 24
Detection of intraneural needle-placement with multiple frequency bioimpedance monitoring: a novel method
Kalvøy, H., & Sauter, A. R. (2015) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-015-9698-3 · Cited by 24
Visfatin Serum Levels in Obese Type 2 Diabetic Patients: Relation to Proinflammatory Cytokines and Insulin Resistance.
Hetta, ‏. F., Eldeen, M. E. E., Mohamed, G. A., Gaber, M. A., ElBadre, H. M., Ahmed, E. A., Abd-ellatief, R. B., El-Baky, R. M. A., Elkady, A., Nafee, A. M. A., et al. (2018) · PubMed · Cited by 24
Psoriasis in obesity: comparison of serum levels of leptin and adiponectin in obese subjects - cases and controls
Bavoso, N. C., Machado‐Pinto, J., Soares, M. M. S., Diniz, M. D. S., & Teixeira, A. L. (2019) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20197716 · Cited by 23
Effects of different obesity-related adipokines on the occurrence of obstructive sleep apnea
Xu, X., & Xu, J. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej20-0036 · Cited by 23
Indices of adiposity as predictors of cardiometabolic risk and inflammation in young adults
Pourshahidi, L. K., Wallace, J. M. W., Mulhern, M. S., Horigan, G., Strain, J., McSorley, E. M., Magee, P. J., Bonham, M. P., & Livingstone, M. B. E. (2015) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12295 · Cited by 22
Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
Osawa, H., Ochi, M., Kato, K., Yamauchi, J., Nishida, W., Takata, Y., Kawamura, R., Onuma, H., Takasuka, T., Shimizu, I., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.144 · Cited by 22
Leptin Promotes cPLA2 Gene Expression through Activation of the MAPK/NF-κB/p300 Cascade
Hsu, P.-S., Wu, C., Chang, J., & Lin, W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161126045 · Cited by 22
Correlations between the expression of the insulin sensitizing hormones, adiponectin, visfatin, and omentin, and the appetite regulatory hormone, neuropeptide Y and its receptors in subcutaneous and visceral adipose tissues
Nway, N. C., Sitticharoon, C., Chatree, S., & Maikaew, P. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2015.05.007 · Cited by 22
Single nucleotide polymorphisms in cytokine/chemokine genes are associated with severe infection, ulcer grade and amputation in diabetic foot ulcer
Viswanathan, V., Umapathy, D., Srinivasan, V., Rajaram, R., & Aravindhan, V. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.083 · Cited by 21
Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.
Shivanna, M., & Srinivas, S. P. (2010) · PubMed · Cited by 20
White, brown, beige and pink: A rainbow in the adipose organ
Cinti, S. (2018) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2018.07.003 · Cited by 20
Low serum omentin levels in the elderly population with Type 2 diabetes and polyneuropathy
Herder, C., Bongaerts, B. W. C., Ouwens, D. M., Rathmann, W., Heier, M., Carstensen‐Kirberg, M., Köenig, W., Thorand, B., Roden, M., Meisinger, C., et al. (2015) · Diabetic Medicine · doi:10.1111/dme.12761 · Cited by 19
Effect of short hairpin RNA-mediated adiponectin/Acrp30 down-regulation on insulin signaling and glucose uptake in the 3T3-L1 adipocytes
Li, K., Li, L., Yang, G., Liu, H., Li, S. B., & Boden, G. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346561 · Cited by 19
Chronic Administration of Visfatin Ameliorated Diabetic Nephropathy in Type 2 Diabetic Mice
Kang, Y. S., Lee, M., Song, H. K., Kim, J. E., Ghee, J. Y., Cha, J. J., Lee, J. E., Kim, H. W., Han, J., & Cha, D. R. (2016) · Kidney & Blood Pressure Research · doi:10.1159/000443433 · Cited by 19
Prevention of overweight and obesity in children and adolescents in European countries
Drewa, A., & Zorena, K. (2017) · Pediatric Endocrinology Diabetes and Metabolism · doi:10.18544/pedm-23.03.0087 · Cited by 18
Self-citation
Evaluation of serum adiponectin levels in diabetic nephropathy
Alnaggar, A. R., Sayed, M. E. E., El-deena, K. E., Gomaa, M. M., & Hamed, Y. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.04.035 · Cited by 18
Etiological Factors of Infections in Diabetic Foot Syndrome – Attempt to Define Optimal Empirical Therapy
Małecki, R., Rosiński, K., & Adamiec, R. (2014) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/37020 · Cited by 17
Neuroretinal Apoptosis as a Vascular Dysfunction in Diabetic Patients
Mrugacz, M., Bryl, A., & Bossowski, A. T. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160523144245 · Cited by 17
Self-citation
Influence of obese phenotype on metabolic profile, inflammatory mediators and stemness of hADSC in adipose tissue
Rawal, K., Patel, T. P., Purohit, K. M., Israni, K., Kataria, V., Bhatt, H., & Gupta, S. S. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.02.032 · Cited by 17
Role of leptin in the regulation of food intake in fasted mice
Ge, T., Yao, X. X., Zhao, F. L., Zou, X. H., Yang, W., Cui, R., & Li, B. J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15110 · Cited by 17
Effect of obesity on the effectiveness of cardiac resynchronization to reduce the risk of first and recurrent ventricular tachyarrhythmia events
Szepietowska, B., Polonsky, B., Sherazi, S., Biton, Y., Kutyifa, V., McNitt, S. A., Aktaş, M. K., Moss, A. J., & Zaręba, W. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0401-x · Cited by 15
Effects of basal insulin application on serum visfatin and adiponectin levels in type 2 diabetes
Wang, W., Xing, L., TENG, J.-R., LI, S., & MI, N. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2428 · Cited by 14
Seminal plasma adipokines: involvement in human reproductive functions
Elfassy, Y., McAvoy, C., Fellahi, S., Dupont, J., Fève, B., Lévy, R., & Bastard, J. (2017) · European Cytokine Network · doi:10.1684/ecn.2018.0403 · Cited by 14
Metabolic syndrome, non-alcoholic fatty liver disease and hepatocarcinoma
Martin, M. S., Guillén, J. R. O., Cano, A. P., & Ramia, J. M. (2020) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2020.6640/2019 · Cited by 14
CORRECTION OF ADIPOCYTE SECRETION DISORDERS IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE WITH OVERWEIGHT AND OBESITY
Pivtorak, K. V., Shevchuk, N. А., Pivtorak, N., & Fedzhaga, I. (2019) · Wiadomości Lekarskie · doi:10.36740/wlek201908111 · Cited by 14
The effect of insulin on net lipid oxidation predicts worsening of insulin resistance and development of type 2 diabetes mellitus
Koška, J., Ortega, E., Bogardus, C., Krakoff, J. A., & Bunt, J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00662.2006 · Cited by 13
Evaluation of changing the pattern of CTRP5 and inflammatory markers levels in patients with coronary artery disease and type 2 diabetes mellitus
Moradi, N., Fadaei, R., Rashidbeygi, E., Kargasheh, F. B., Malek, M., Nahrkhalaji, A. S., & Fallah, S. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1742164 · Cited by 12
Certification of deaths from diabetes mellitus and obesity in England: trends into the twenty-first century
Duncan, M. E., & Goldacre, M. J. (2012) · Journal of Public Health · doi:10.1093/pubmed/fds074 · Cited by 10
Circulating Chemerin Levels are Increased in First-Degree Relatives of Type 2 Diabetic Patients
Zhuang, X., Sun, F., Chen, S., Liu, Y., Liu, W., Li, X., Pan, Z., & Lou, N. (2014) · Clinical Laboratory · doi:10.7754/clin.lab.2013.130503 · Cited by 9
Does obesity influence target organ damage and outcomes in patients with malignant phase hypertension? The West Birmingham Malignant Hypertension Project
Shantsila, A., Lane, D. A., Beevers, D. G., & Lip, G. Y. H. (2013) · Hypertension Research · doi:10.1038/hr.2012.222 · Cited by 3

Flagged first, then by citations

4 of the 126 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Jachimowicz-Duda, O., Wąż, P., and Zorena, K. (2015, January 19–24). Interleukin-34 concentration is dependent on LDL cholesterol, HbA1c, CRP and WHR in patients with type 2 diabetes. Proceedings of the Crossroads of Lipid Metabolism and Diabetes 2015, Copenhagen, Denmark.
Jachomowicz-Duda, O., Wąż, P., and Zorena, K. (2017, January 28–29). The relationship between interleukin-34 level and selected biochemical and clinical parameters in patients with type 2 diabetes. Proceedings of the Synergy Conference: “Autoimmunity in 2017-Where Are We Now?”, New York, NY, USA.

Sorted by citations

The role of adipokines in health and disease
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11051290 · Cited by 463
The role of adipokines in inflammatory mechanisms of obesity
Kirichenko, T. V., Markina, Y. V., Bogatyreva, A. I., Tolstik, T. V., Varaeva, Y. R., & Starodubova, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314982 · Cited by 289
Iron Metabolism in Obesity and Metabolic Syndrome
González-Domínguez, Á., Visiedo-García, F. M., Domínguez-Riscart, J., González-Domínguez, R., Mateos, R. M., & Lechuga-Sancho, A. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155529 · Cited by 227
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)
Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 232
Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs
Lee, M.-W., Lee, M., & Oh, K. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060854 · Cited by 192

See all 411

Authors: Zorena, K., Jachimowicz-Duda, O., Ślęzak, D., Robakowska, M., & Mrugacz, M.
Affiliations: Gdańsk Medical University (PL)
Independent Public Specialized Health Care Center in Lębork, Department of Internal Diseases, Węgrzynowicza 13, 84-300 Lębork, Poland
Medical University of Białystok (PL)
Corresponding author: Zorena, Katarzyna
ORCID: Zorena, Katarzyna
Ślęzak, Daniel
Robakowska, Marlena
Mrugacz, Małgorzata
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2020-05-18
Volume: 21
Issue: 10
Pages: 3570
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms21103570
PMC: PMC7278967
OpenAlex: W3024358488
Cited by: 411
References: 126
Citations by year: 2026: 39 · 2025: 61 · 2024: 105 · 2023: 86 · 2022: 73 · 2021: 35 · 2020: 11
FWCI: 7.46
Type: journal article
Language: en
Open access: gold
dx.doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adipokines, obesity, metabolic disorders, chronic complications, insulin resistance, inflammation, cytokines, adipose tissue, brown adipose tissue, perivascular adipose tissue, obesity-related comorbidities
MeSH terms: Animals, Humans, Inflammation, Metabolic Diseases, Obesity, Adipokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks