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Cited by 484Synthesis and biological activityBioactive natural compoundsSynthesis of Organic Compounds

Cinnamic Acid Derivatives and Their Biological Efficacy

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Ruwizhi, Ngonidzashe, Aderibigbe, Blessing Atim·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21165712PMC PMC7460980
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Abstract

The role played by cinnamic acid derivatives in treating cancer, bacterial infections, diabetes and neurological disorders, among many, has been reported. Cinnamic acid is obtained from cinnamon bark. Its structure is composed of a benzene ring, an alkene double bond and an acrylic acid functional group making it possible to modify the aforementioned functionalities with a variety of compounds resulting in bioactive agents with enhanced efficacy. The nature of the substituents incorporated into cinnamic acid has been found to play a huge role in either enhancing or decreasing the biological efficacy of the synthesized cinnamic acid derivatives. Some of the derivatives have been reported to be more effective when compared to the standard drugs used to treat chronic or infectious diseases in vitro, thus making them very promising therapeutic agents. Compound 20 displayed potent anti-TB activity, compound 27 exhibited significant antibacterial activity on S. aureus strain of bacteria and compounds with potent antimalarial activity are 35a, 35g, 35i, 36i, and 36b. Furthermore, compounds 43d, 44o, 55g–55p, 59e, 59g displayed potent anticancer activity and compounds 86f–h were active against both hAChE and hBuChE. This review will expound on the recent advances on cinnamic acid derivatives and their biological efficacy.

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  • Cinnamic acid derivatives bind amyloid beta (Aβ) proteins.

    “Cinnamic acid derivatives are known to bind with amyloid beta (Aβ) proteins.[14]”

    From Lipid Nanoparticles Enhance mRNA Delivery to the Central Nervous System Upon Intrathecal Injection (2025) · cites this paper as [14]

    Section 5 (page not provided) reports that tacrine–cinnamic acid hybrids inhibited Aβ1–42 aggregation, supporting an effect on amyloid beta. It does not establish that the derivatives bind Aβ proteins; the binding interactions it describes are with cholinesterases. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Authors
Ruwizhi, N., & Aderibigbe, B. A.
Affiliations
University of Fort Hare (ZA)
Corresponding author
Aderibigbe, Blessing Atim
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-08-09
Volume
21
Issue
16
Pages
5712
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21165712
PMC
PMC7460980
OpenAlex
W3047987759
Cited by
484
References
1
Citations by year
2026: 77 · 2025: 109 · 2024: 116 · 2023: 96 · 2022: 60 · 2021: 24 · 2020: 1
FWCI
3.48
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
South African Medical Research Council (SAMRC)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
  • Health Sciences › Medicine › Pharmacology › Synthesis of Organic Compounds
Keywords
cinnamic acid derivatives, bioactive compounds, anticancer activity, antibacterial activity, antimalarial activity, antitubercular activity, Staphylococcus aureus, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, diabetes mellitus, neurological disorders, structure-activity relationship, substituent effects, cinnamon
MeSH terms
Animals, Anti-Infective Agents, Antioxidants, Bacteria, Cholinesterase Inhibitors, Cinnamates, Fungi, Humans, Structure-Activity Relationship, Molecular Structure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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