Cited by 189Coenzyme Q10 studies and effectsMetabolism and Genetic DisordersNeurological diseases and metabolism

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Disorders of Human Coenzyme Q10 Metabolism: An Overview

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Hargreaves, Iain, Heaton, Robert A., Mantle, David·2020·International Journal of Molecular Sciences

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Abstract

Coenzyme Q10 (CoQ10) has a number of vital functions in all cells, both mitochondrial and extramitochondrial. In addition to its key role in mitochondrial oxidative phosphorylation, CoQ10 serves as a lipid soluble antioxidant, plays an important role in fatty acid, pyrimidine and lysosomal metabolism, as well as directly mediating the expression of a number of genes, including those involved in inflammation. In view of the central role of CoQ10 in cellular metabolism, it is unsurprising that a CoQ10 deficiency is linked to the pathogenesis of a range of disorders. CoQ10 deficiency is broadly classified into primary or secondary deficiencies. Primary deficiencies result from genetic defects in the multi-step biochemical pathway of CoQ10 synthesis, whereas secondary deficiencies can occur as result of other diseases or certain pharmacotherapies. In this article we have reviewed the clinical consequences of primary and secondary CoQ10 deficiencies, as well as providing some examples of the successful use of CoQ10 supplementation in the treatment of disease.

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Biochemical, physiological and medical aspects of ubiquinone function
Ernster, L., & Dallner, G. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00028-3 · Cited by 1,246
Biochemical Functions of Coenzyme Q 10
Crane, F. L. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719063 · Cited by 869
The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure
Mortensen, S. A., Rosenfeldt, F., Kumar, A., Dolliner, P., Filipiak, K. J., Pella, D., Alehagen, U., Steurer, G., & Littarru, G. P. (2014) · JACC: Heart Failure · doi:10.1016/j.jchf.2014.06.008 · Cited by 488
Age‐related changes in the lipid compositions of rat and human tissues
Kalén, A., Appelkvist, E., & Dallner, G. (1989) · Lipids · doi:10.1007/bf02535072 · Cited by 425
Mitochondrial dysfunction in inherited renal disease and acute kidney injury
Emma, F., Montini, G., Parikh, S. M., & Salviati, L. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.214 · Cited by 400
Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy.
Ogasahara, S., Engel, A. G., Frens, D. B., & Mack, D. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2379 · Cited by 365
COQ2 Nephropathy
Diomedi‐Camassei, F., Giandomenico, S. D., Santorelli, F. M., Caridi, G., Piemonte, F., Montini, G., Ghiggeri, G. M., Murer, L., Barisoni, L. M. C., Pastore, A., et al. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006080833 · Cited by 331
Biochemistry of Mitochondrial Coenzyme Q Biosynthesis
Stefely, J. A., & Pagliarini, D. J. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.06.008 · Cited by 329
The myopathic form of coenzyme Q10 deficiency is caused by mutations in the electron-transferring-flavoprotein dehydrogenase (ETFDH) gene
Gempel, K. E., Topaloğlu, H., Talim, B., Schneiderat, P., Schoser, B. G. H., Hans, V., Pálmafy, B., Kale, G., Tokatlı, A., Quinzii, C. M., et al. (2007) · Brain · doi:10.1093/brain/awm054 · Cited by 313
High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial
PAIVA, H., THELEN, K., COSTER, R., SMET, J., PAEPE, B., MATTILA, K., LAAKSO, J., LEHTIMAKI, T., VONBERGMANN, K., & LUTJOHANN, D. (2005) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.03.006 · Cited by 308

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Villalba, 2018, Coenzyme Q10: From bench to clinic in aging diseases, a translational review, Crit. Rev. Food Sci. Nutr., 59, 2240
Emmanuele, 2012, Heterogeneity of Coenzyme Q10Deficiency, Arch. Neurol., 69, 978

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Herbrich, S., Ramachandran, H., Seibt, A., Tolle, I., Zink, A., Prigione, A., Rossi, A., & Distelmaier, F. (2025) · Stem Cell Research · doi:10.1016/j.scr.2025.103825
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Coenzyme Q10 in Pediatric Nutrition
Patel, N. (2025) · Springer eBooks · doi:10.1007/978-3-031-97759-6_29
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Oulehri, W. (2024) · theses.fr (ABES) · doi:10.70675/451dcb10z4d36z4499zac89z3a6033aa0bc5
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Pinto, M. M. (2024) · theses.fr (ABES) · doi:10.70675/0b7d0a11z0a92z4cdcz8767z5c047116d503
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Patrício, J. S., Guerreiro, A. C. L., Gameiro, P. A., & Morelló, J. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_19
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Gao, G., Li, N., Zhao, Y., Zhang, T., Zhao, C., Lian, S., Zhang, Y., Hu, R., & Sun, Z. (2026) · npj Science of Food · doi:10.1038/s41538-026-01040-x
Psychiatric Comorbidities of Neurogenetic and Neurodegenerative Diseases
(2026) · Frontiers research topics · doi:10.3389/978-2-8325-8487-3
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Güneş, M. S. A., Yekedüz, M. K., Köse, E., Kara, İ. S., & Eminoğlu, F. T. (2026) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2026.110247
Advances in diagnosis of mitochondrial dysfunction and primary mitochondrial disease
Köse, M., McCormick, E. M., Peterson, J. T., Muraresku, C. C., Viaene, A. N., Zolkipli‐Cunningham, Z., & Falk, M. J. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052804

Authors: Hargreaves, I., Heaton, R. A., & Mantle, D.
Affiliations: Liverpool John Moores University (GB)
Pharma Nord (United Kingdom) (GB)
Corresponding author: Hargreaves, Iain
ORCID: Hargreaves, Iain
Heaton, Robert A.
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2020-09-13
Volume: 21
Issue: 18
Pages: 6695
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms21186695
PMC: PMC7555759
OpenAlex: W3085499101
Cited by: 182
References: 93
Citations by year: 2026: 18 · 2025: 44 · 2024: 36 · 2023: 37 · 2022: 35 · 2021: 9 · 2020: 2
FWCI: 1.99
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Liverpool John Moores University (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: coenzyme Q10, CoQ10 deficiency, CoQ10 biosynthesis, mitochondrial oxidative phosphorylation, antioxidant function, fatty acid metabolism, lysosomal metabolism, inflammation, coenzyme Q10 supplementation, genetic disorders
MeSH terms: Antioxidants, Ataxia, Humans, Inflammation, Ubiquinone, Muscle Weakness, Mitochondrial Diseases

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Disorders of Human Coenzyme Q10 Metabolism: An Overview

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