Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia
Open accessAbstract
It is established that cancer cachexia causes limb muscle atrophy and is strongly associated with morbidity and mortality; less is known about how the development of cachexia impacts the diaphragm. The purpose of this study was to investigate cellular signaling mechanisms related to mitochondrial function, reactive oxygen species (ROS) production, and protein synthesis during the development of cancer cachexia. C57BL/J6 mice developed Lewis Lung Carcinoma for either 0 weeks (Control), 1 week, 2 weeks, 3 weeks, or 4 weeks. At designated time points, diaphragms were harvested and analyzed. Mitochondrial respiratory control ratio was ~50% lower in experimental groups, which was significant by 2 weeks of cancer development, with no difference in mitochondrial content markers COXIV or VDAC. Compared to the controls, ROS was 4-fold elevated in 2-week animals but then was not different at later time points. Only one antioxidant protein, GPX3, was altered by cancer development (~70% lower in experimental groups). Protein synthesis, measured by a fractional synthesis rate, appeared to become progressively lower with the cancer duration, but the mean difference was not significant. The development and progression of cancer cachexia induces marked alterations to mitochondrial function and ROS production in the diaphragm and may contribute to increased cachexia-associated morbidity and mortality.
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Mitochondria biogenesis plays a critical role in metabolic and physiological adaptation of skeletal muscle.
“Mitochondria biogenesis play a critical role in the metabolic and physiological adaptation of skeletal muscle [67].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [67]
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Cites
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894 · see citing works
Definition and classification of cancer cachexia: an international consensus
Fearon, K., Strasser, F., Anker, S. D., Bosaeus, I. G., Bruera, E. D., Fainsinger, R. L., Jatoi, A., Loprinzi, C. L., Macdonald, N., Mantovani, G., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70218-7 · Cited by 5,800 · see citing works
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy · doi:10.4161/auto.19496 · Cited by 3,996 · see citing works
Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436 · see citing works
Prognostic effect of weight loss prior tochemotherapy in cancer patients
DeWys, W. D., Begg, C. B., Lavin, P. T., Band, P. R., Bennett, J. M., Bertino, J. R., Cohen, M. H., Douglass, H. O., Engstrom, P. F., Ezdinli, E. Z., et al. (1980) · The American Journal of Medicine · doi:10.1016/s0149-2918(05)80001-3 · Cited by 2,350 · see citing works
Mechanical Ventilation–induced Diaphragm Atrophy Strongly Impacts Clinical Outcomes
Goligher, E. C., Dres, M., Fan, E., Rubenfeld, G. D., Scales, D. C., Herridge, M. S., Vorona, S., Sklar, M. C., Rittayamai, N., Lanys, A., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0536oc · Cited by 825 · see citing works
Diagnostic Criteria for the Classification of Cancer-Associated Weight Loss
Martin, L., Sénesse, P., Gioulbasanis, I., Antoun, S., Bozzetti, F., Deans, C., Strasser, F., Thoresen, L., Jagoe, R. T., Chasen, M. R., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.56.1894 · Cited by 799 · see citing works
Skeletal muscle loss: cachexia, sarcopenia, and inactivity
Evans, W. J. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.28608a · Cited by 724 · see citing works
Hermans, G., Mechelen, H. V., Clerckx, B., Vanhullebusch, T., Mesotten, D., Wilmer, A. P., Casaer, M. P., Meersseman, P., Debaveye, Y. A., Cromphaut, S. J. V., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201312-2257oc · Cited by 536 · see citing works
Trends and Patterns of Disparities in Cancer Mortality Among US Counties, 1980-2014
Mokdad, A. H., Dwyer‐Lindgren, L., Fitzmaurice, C., Stubbs, R. W., Bertozzi-Villa, A., Morozoff, C., Charara, R. N., Allen, C., Naghavi, M., & Murray, C. J. L. (2017) · JAMA · doi:10.1001/jama.2016.20324 · Cited by 399 · see citing works
Brown, J. L., Rosa‐Caldwell, M. E., Lee, D. E., Blackwell, T. A., Brown, L. A., Perry, R. A., Haynie, W. S., Hardee, J. P., Carson, J. A., Wiggs, M. P., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12232 · Cited by 288 · see citing works
Self-citationSarcopenia Is Linked to Treatment Toxicity in Patients With Metastatic Colorectal Cancer
Barret, M., Antoun, S., Dalban, C., Malka, D., Mansourbakht, T., Zaanan, A., Latko, E., & Taı̈eb, J. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.894103 · Cited by 242 · see citing works
Colorectal Cancer Mortality Rates in Adults Aged 20 to 54 Years in the United States, 1970-2014
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · JAMA · doi:10.1001/jama.2017.7630 · Cited by 242 · see citing works
Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients
Hooijman, P. E., Beishuizen, A., Witt, C. C., de Waard, M. C., Girbes, A. R. J., de Man, A., Niessen, H. W. M., Manders, E., van Hees, H. W. H., van den Brom, C. E., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201412-2214oc · Cited by 230 · see citing works
Huillard, O., Mir, O., Peyromaure, M., Tlemsani, C., Giroux, J., Boudou, P., Ropert, S., Delongchamps, N. B., Zerbib, M., & Goldwasser, F. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.58 · Cited by 226 · see citing works
Puig-Vilanova, E., Rodriguez, D. A., Lloreta, J., Ausin, P., Pascual-Guardia, S., Broquetas, J., Roca, J., Gea, J., & Barreiro, E. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.006 · Cited by 167 · see citing works
Min, K., Kwon, O., Smuder, A. J., Wiggs, M. P., Sollanek, K. J., Christou, D. D., Yoo, J., Hwang, M., Szeto, H. H., Kavazis, A. N., et al. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.286518 · Cited by 150 · see citing works
Self-citationSun, L., Quan, X., & Yu, S. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1073753 · Cited by 138 · see citing works
Hughes, M. C., Ramos, S. V., Turnbull, P. C., Rebalka, I. A., Cao, A. W., Monaco, C. M. F., Varah, N. E., Edgett, B. A., Huber, J. S., Tadi, P., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12405 · Cited by 133 · see citing works
Cancer Cachexia, Malnutrition, and Tissue Protein Turnover in Experimental Animals
Tessitore, L., Costelli, P., Bonetti, G., & Baccino, F. M. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1479 · Cited by 126 · see citing works
Cachexia in cancer: what is in the definition?
Vanhoutte, G., van de Wiel, M., Wouters, K., Sels, M., Bartolomeeussen, L., Keersmaecker, S. D., Verschueren, C., Vroey, V. D., Wilde, A. D., Smits, E., et al. (2016) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2016-000097 · Cited by 125 · see citing works
Murphy, K. T., Chee, A., Trieu, J., Naim, T., & Lynch, G. S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.008839 · Cited by 114 · see citing works
Judge, S. M., Wu, C.-L., Beharry, A. W., Roberts, B. M., Ferreira, L. F., Kandarian, S. C., & Judge, A. R. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-997 · Cited by 111 · see citing works
Antibody-Directed Myostatin Inhibition Enhances Muscle Mass and Function in Tumor-Bearing Mice
Murphy, K. T., Chee, A., Gleeson, B. G., Naim, T., Swiderski, K., Koopman, R., & Lynch, G. S. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00121.2011 · Cited by 111 · see citing works
Diaphragm and ventilatory dysfunction during cancer cachexia
Roberts, B. M., Ahn, B., Smuder, A. J., Al‐Rajhi, M., Gill, L., Beharry, A. W., Powers, S. K., Fuller, D. D., Ferreira, L. F., & Judge, A. R. (2013) · The FASEB Journal · doi:10.1096/fj.12-222844 · Cited by 108 · see citing works
Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice
Brown, J. L., Lee, D. E., Rosa-Caldwell, M., Brown, L., Perry, R. A., Haynie, W. S., Huseman, K., Sataranatarajan, K., Remmen, H. V., Washington, T. A., et al. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12354 · Cited by 98 · see citing works
Self-citationGreene, N. P., Lee, D. E., Brown, J. L., Rosa, M. E., Brown, L. A., Perry, R. A., Henry, J. N., & Washington, T. A. (2015) · Physiological Reports · doi:10.14814/phy2.12470 · Cited by 89 · see citing works
Self-citationChacon‐Cabrera, A., Fermoselle, C., Urtreger, A. J., Mateu-Jiménez, M., Diament, M., Joffé, E. B. D. K., Sandri, M., & Barreiro, E. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24611 · Cited by 88 · see citing works
Fermoselle, C., García‐Arumí, E., Puig‐Vilanova, E., Andreu, A. L., Urtreger, A. J., Joffé, E. B. D. K., Tejedor, A., Puente‐Maestu, L., & Barreiro, E. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.072496 · Cited by 67 · see citing works
Puig‐Vilanova, E., Aguiló, R., Rodríguez-Fuster, A., Martínez‐Llorens, J., Gea, J., & Barreiro, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111514 · Cited by 64 · see citing works
Hepatic alterations during the development and progression of cancer cachexia
Rosa‐Caldwell, M. E., Brown, J. L., Lee, D. E., Wiggs, M. P., Perry, R. A., Haynie, W. S., Caldwell, A. R., Washington, T. A., Lo, W.-J., & Greene, N. P. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0407 · Cited by 57 · see citing works
Self-citationModerate physical activity promotes basal hepatic autophagy in diet-induced obese mice
Rosa‐Caldwell, M. E., Lee, D. E., Brown, J. L., Brown, L. A., Perry, R. A., Greene, E. S., Carvallo, F. R., Washington, T. A., & Greene, N. P. (2016) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2016-0280 · Cited by 56 · see citing works
Self-citationChacón-Cabrera, A., Mateu-Jiménez, M., Langohr, K., Fermoselle, C., García-Arumí, E., Andreu, A., Yélamos, J., & Barreiro, E. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25851 · Cited by 52 · see citing works
Leitner, L. M., Wilson, R. J., Yan, Z., & Gödecke, A. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6942 · Cited by 51 · see citing works
Insulin resistance syndrome blunts the mitochondrial anabolic response following resistance exercise
Nilsson, M. I., Greene, N. P., Dobson, J. P., Wiggs, M. P., Gasier, H. G., Macias, B. R., Shimkus, K. L., & Fluckey, J. D. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00118.2010 · Cited by 50 · see citing works
Self-citationKritsiligkou, P., Chatzi, A., Charalampous, G., Mironov, A., Grant, C. M., & Tokatlidis, K. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.053 · Cited by 45 · see citing works
Halle, J. L., Pena, G. S., Paez, H., Castro, A. J., Rossiter, H., Visavadiya, N. P., Whitehurst, M., & Khamoui, A. V. (2019) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2019 · Cited by 44 · see citing works
Nosacka, R. L., Delitto, A. E., Delitto, D., Patel, R., Judge, S. M., Trevino, J. G., & Judge, A. R. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12550 · Cited by 42 · see citing works
Ventilator-induced diaphragm dysfunction in critical illness
Liu, Y.-Y., & Li, L. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218811950 · Cited by 34 · see citing works
Salazar-Degracia, A., Blanco, D., Vilà-Ubach, M., de Biurrun, G., de Solórzano, C. O., Montuenga, L., & Barreiro, E. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1003-9 · Cited by 28 · see citing works
Kwon, I., Lee, Y., Cosío-Lima, L., Cho, J., & Yeom, D.-C. (2015) · Physical Activity and Nutrition · doi:10.5717/jenb.2015.15090710 · Cited by 27 · see citing works
Lee, D. E., Brown, J. L., Rosa‐Caldwell, M. E., Perry, R. A., Brown, L. A., Haynie, W. S., Washington, T. A., Wiggs, M. P., Rajaram, N., & Greene, N. P. (2020) · JCSM Rapid Communications · doi:10.1002/rco2.18 · Cited by 24 · see citing works
Self-citationSalazar-Degracia, A., Busquets, S., Argiles, J., López-Soriano, F., & Barreiro, E. (2017) · PeerJ · doi:10.7717/peerj.4109 · Cited by 23 · see citing works
Muscle alterations in the development and progression of cancer-induced muscle atrophy: A Review.
Rosa-Caldwell, M., Fix, D. K., Washington, T. A., & Greene, N. (2019) · Journal of applied physiology · doi:10.1152/japplphysiol.00622.2019 · Cited by 21 · see citing works
Self-citationRyan, Z. C., Craig, T. A., Wang, X., Delmotte, P. F., Salisbury, J. L., Lanza, I. R., Sieck, G. C., & Kumar, R. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.092 · Cited by 19 · see citing works
Rosa‐Caldwell, M. E., Brown, J. L., Lee, D. E., Blackwell, T. A., Turner, K. W., Brown, L. A., Perry, R. A., Haynie, W. S., Washington, T. A., & Greene, N. P. (2017) · Experimental Physiology · doi:10.1113/ep086406 · Cited by 16 · see citing works
Self-citationCancer cachexia impairs neural respiratory drive in hypoxia but not hypercapnia
Fields, D. P., Roberts, B. M., Simon, A. K., Judge, A. R., Fuller, D. D., & Mitchell, G. S. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12348 · Cited by 12 · see citing works
Effects of Ionizing Irradiation on Mouse Diaphragmatic Skeletal Muscle
Zhou, T., Lu, L., Wu, S., & Zuo, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00506 · Cited by 10 · see citing works
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2 of the 50 references couldn’t be matched to a known paper.
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Hyatt, H. W., & Powers, S. K. (2021) · Antioxidants · doi:10.3390/antiox10040588 · Cited by 127 · see citing works
Delfinis, L. J., Bellissimo, C. A., Gandhi, S., DiBenedetto, S. N., Garibotti, M. C., Thuhan, A. K., Tsitkanou, S., Rosa‐Caldwell, M. E., Rahman, F. A., Cheng, A. J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155147 · Cited by 73 · see citing works
Self-citationNutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
Cancer cachexia as a multiorgan failure: Reconstruction of the crime scene
Ferrara, M., Samaden, M., Ruggieri, E., & Vénéreau, E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.960341 · Cited by 42 · see citing works
Immunoregulation in cancer-associated cachexia
Wu, Q., Liu, Z., Li, B., Liu, Y., & Wang, P. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.04.018 · Cited by 39 · see citing works
Exploring heterogeneity: a dive into preclinical models of cancer cachexia
da Silva, F. M., Cabrera, A. R., & Greene, N. P. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00317.2024 · Cited by 20 · see citing works
Self-citationImpact of cancer cachexia on respiratory muscle function and the therapeutic potential of exercise
Murphy, B. T., Mackrill, J. J., & O’Halloran, K. D. (2022) · The Journal of Physiology · doi:10.1113/jp283569 · Cited by 20 · see citing works
Schmich, S. K. P., Keck, J., Bonaterra, G. A., Bertoune, M., Adam, A., Wilhelm, B., Slater, E. P., Schwarzbach, H., Fendrich, V., Kinscherf, R., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11030912 · Cited by 6 · see citing works
Diet-induced obesity does not exacerbate cachexia in male mice bearing Lewis-lung carcinoma tumors
Beaudry, A. G., Law, M. L., Gilley, K., Buley, H., Dungan, C. M., Nascimento, C. M. C., Vichaya, E. G., & Wiggs, M. P. (2024) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2023 · Cited by 5 · see citing works
Self-citationGL261 glioblastoma induces delayed body weight gain and stunted skeletal muscle growth in young mice
Huot, J. R., Jamnick, N. A., Pin, F., Livingston, P. D., Callaway, C. S., Morrow, S. K., & Bonetto, A. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00035.2025 · Cited by 4 · see citing works
Pharmacokinetic Implications of Pathophysiological Changes in Cachexia Syndrome: A Scoping Review
Khan, S., Kalam, M. N., Khalid, M., Mehmood, M. H., Malik, U. R., & Ali, S. M. (2025) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-025-00967-y · Cited by 1 · see citing works
Tumour-driven lipid accumulation in oenocytes reflects systemic lipid alterations
Liu, C., Golenkina, S., Fahey, N., Kumar, P., & Cheng, L. Y. (2026) · PLoS Genetics · doi:10.1371/journal.pgen.1012150
Wanders, N., Martens, M., KELDERS, M. C. J. M., Manse, S., van Krimpen, S. J., Groenen, C., Kapsali, C., Fraile, P. B., Bermperi, K., Boumans, N., et al. (2026) · Cancers · doi:10.3390/cancers18132130
- Authors
- Rosa-Caldwell, M. E., Benson, C. A., Lee, D. E., Brown, J. L., Washington, T. A., Greene, N. P., & Wiggs, M. P.
- Affiliations
- Exercise Science Research Center, Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR 72701, USA
- The University of Texas at Tyler (US)
- University of Arkansas at Fayetteville (US)
- Baylor University (US)
- Corresponding author
- Wiggs, Michael P.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-10-22
- Volume
- 21
- Issue
- 21
- Pages
- 7841
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC7660065
- OpenAlex
- W3093666204
- Cited by
- 13
- References
- 50
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Scholar Works at UT Tyler (The University of Texas at Tyler) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R15AR06991)
- Arkansas Biosciences Institute (Arkansas Biosciences Institute)
- The Institute for Integrated Healthcare, University of Texas at Tyler (The Institute for Integrated Healthcare, University of Texas at Tyler)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- cancer cachexia, diaphragm, mitochondrial function, respiratory control ratio, reactive oxygen species, protein synthesis, glutathione peroxidase 3, Lewis lung carcinoma, muscle atrophy, oxidative stress, antioxidant proteins
- MeSH terms
- Forkhead Box Protein O3, Animals, Antioxidants, Cachexia, Diaphragm, Glutathione Peroxidase, Male, Mice, Inbred C57BL, Mitochondria, Muscle, Muscle Proteins, Signal Transduction, Reactive Oxygen Species, Carcinoma, Lewis Lung
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