Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn923 · Cited by 14,108 · see citing works

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,185 · see citing works

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2004) · Cell · doi:10.1016/s0092-8674(04)00400-3 · Cited by 3,012 · see citing works

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953 · see citing works

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,797 · see citing works

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Lecker, S. H., Jagoe, R. T., Gilbert, A., Gomes, M., Baracos, V., Bailey, J., Price, S. R., Mitch, W. E., & Goldberg, A. L. (2004) · The FASEB Journal · doi:10.1096/fj.03-0610com · Cited by 1,539 · see citing works

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489 · see citing works

IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works

Mechanisms of Cancer Cachexia

Tisdale, M. J. (2009) · Physiological Reviews · doi:10.1152/physrev.00016.2008 · Cited by 1,192 · see citing works

Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?

Andreyev, J. N., Norman, A. R., Oates, J. R., & Cunningham, D. (1998) · European Journal of Cancer · doi:10.1016/s0959-8049(97)10090-9 · Cited by 797 · see citing works

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585 · see citing works

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

Zolotukhin, S., Potter, M., Zolotukhin, I., Sakai, Y., Loiler, S., Fraites, T. J., Chiodo, V. A., Philipsberg, T., Muzyczka, N., Hauswirth, W. W., et al. (2002) · Methods · doi:10.1016/s1046-2023(02)00220-7 · Cited by 556 · see citing works

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

Potente, M., Urbich, C., Sasaki, K., Hofmann, W. K., Heeschen, C., Aicher, A., Kollipara, R., DePinho, R. A., Zeiher, A. M., & Dimmeler, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23126 · Cited by 527 · see citing works

Collagen VI regulates satellite cell self-renewal and muscle regeneration

Urciuolo, A., Quarta, M., Morbidoni, V., Gattazzo, F., Molon, S., Grumati, P., Montemurro, F., Tedesco, F. S., Blaauw, B., Cossu, G., et al. (2013) · Nature Communications · doi:10.1038/ncomms2964 · Cited by 511 · see citing works

Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins

Jen, Y., Weintraub, H., & Benezra, R. (1992) · Genes & Development · doi:10.1101/gad.6.8.1466 · Cited by 471 · see citing works

BMP signaling controls muscle mass

Sartori, R., Schirwis, E., Blaauw, B., Bortolanza, S., Zhao, J., Enzo, E., Stantzou, A., Mouisel, E., Toniolo, L., Ferry, A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2772 · Cited by 467 · see citing works

JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia

Bonetto, A., Aydogdu, T., Jin, X., Zhang, Z., Zhan, R., Puzis, L., Koniaris, L. G., & Zimmers, T. A. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2012 · Cited by 463 · see citing works

Cachexia Worsens Prognosis in Patients with Resectable Pancreatic Cancer

Bachmann, J., Heiligensetzer, M., Krakowski‐Roosen, H., Büchler, M. W., Friess, H., & Martignoni, M. E. (2008) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-008-0505-z · Cited by 429 · see citing works

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR

Ramaswamy, S., Nakamura, N., Sansal, I., Bergeron, L., & Sellers, W. R. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00086-7 · Cited by 428 · see citing works

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

Roberts, E. W., Deonarine, A., Jones, J. O., Denton, A. E., Feig, C., Lyons, S. K., Espéli, M., Kraman, M., McKenna, B., Wells, R. J. B., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122344 · Cited by 417 · see citing works

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

Waddell, D. S., Baehr, L. M., van den Brandt, J., Johnsen, S. A., Reichardt, H. M., Furlow, J. D., & Bodine, S. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00646.2007 · Cited by 360 · see citing works

NF-κB–mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia

He, W. A., Berardi, E., Cardillo, V. M., Acharyya, S., Aulino, P., Thomas-Ahner, J., Wang, J., Bloomston, M., Muscarella, P., Nau, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68523 · Cited by 357 · see citing works

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

Bonetto, A., Aydogdu, T., Kunzevitzky, N., Guttridge, D. C., Khuri, S., Koniaris, L. G., & Zimmers, T. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022538 · Cited by 348 · see citing works

Dystrophin glycoprotein complex dysfunction: A regulatory link between muscular dystrophy and cancer cachexia

Acharyya, S., Butchbach, M. E. R., Sahenk, Z., Wang, H., Saji, M., Carathers, M., Ringel, M. D., Skipworth, R. J. E., Fearon, K. C. H., Hollingsworth, M. A., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.004 · Cited by 316 · see citing works

Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy

Zhou, Q., Chu, P., Huang, C., Cheng, C., Martone, M. E., Knoll, G., Shelton, G. D., Evans, S. Μ., & Chen, J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200107092 · Cited by 283 · see citing works

Cancer Cachexia: Mechanisms and Clinical Implications

Donohoe, C. L., Ryan, A. M., & Reynolds, J. V. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/601434 · Cited by 273 · see citing works

Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle

Stevenson, E. J., Giresi, P. G., Koncarevic, A., & Kandarian, S. C. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00033.x · Cited by 270 · see citing works

Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6

Blankinship, M. J., Gregorevic, P., Allen, J. M., Harper, S. Q., Harper, H. A., Halbert, C. L., Miller, A. D., & Chamberlain, J. S. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.07.016 · Cited by 250 · see citing works

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

Reed, S. A., Sandesara, P. B., Judge, S. M., & Judge, A. R. (2011) · The FASEB Journal · doi:10.1096/fj.11-189977 · Cited by 224 · see citing works

Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle

Stevenson, E. J., Giresi, P. G., Koncarevic, A., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.044701 · Cited by 212 · see citing works

FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.

Senf, S. M., Dodd, S., & Judge, A. (2010) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00315.2009 · Cited by 208 · see citing works

Muscle Wasting and Impaired Myogenesis in Tumor Bearing Mice Are Prevented by ERK Inhibition

Penna, F., Costamagna, D., Fanzani, A., Bonelli, G., Baccino, F. M., & Costelli, P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013604 · Cited by 191 · see citing works

Calsarcin-3, a Novel Skeletal Muscle-specific Member of the Calsarcin Family, Interacts with Multiple Z-disc Proteins

Frey, N., & Olson, E. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200712200 · Cited by 189 · see citing works

Inflammation Based Regulation of Cancer Cachexia

Onesti, J. K., & D, D. C. G. (2014) · BioMed Research International · doi:10.1155/2014/168407 · Cited by 157 · see citing works

Muscle Interstitial Fibroblasts Are the Main Source of Collagen VI Synthesis in Skeletal Muscle: Implications for Congenital Muscular Dystrophy Types Ullrich and Bethlem

Zou, Y., Zhang, R.-Z., Sabatelli, P., Chu, M.-L., & Bönnemann, C. G. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181634ef7 · Cited by 155 · see citing works

Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia.

Smith, K., & Tisdale, M. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.126 · Cited by 149 · see citing works

C/EBPβ mediates tumour‐induced ubiquitin ligase atrogin1/MAFbx upregulation and muscle wasting

Zhang, G., Jin, B., & Li, Y. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.292 · Cited by 136 · see citing works

HDAC1 activates FoxO and is both sufficient and required for skeletal muscle atrophy

Beharry, A. W., Sandesara, P. B., Roberts, B. M., Ferreira, L. F., Senf, S. M., & Judge, A. R. (2014) · Journal of Cell Science · doi:10.1242/jcs.136390 · Cited by 128 · see citing works

IκBα Ubiquitination Is Catalyzed by an SCF-like Complex Containing Skp1, Cullin-1, and Two F-Box/WD40-Repeat Proteins, βTrCP1 and βTrCP2

Suzuki, H., Chiba, T., Kobayashi, M., Takeuchi, M., Suzuki, T., Ichiyama, A., Ikenoue, T., Omata, M., Furuichi, K., & Tanaka, K. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0289 · Cited by 122 · see citing works

p300 Acetyltransferase activity differentially regulates the localization and activity of the FOXO homologues in skeletal muscle

Judge, S. M., Sandesara, P. B., Reed, S. A., & Judge, A. R. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00255.2010 · Cited by 108 · see citing works

Diaphragm and ventilatory dysfunction during cancer cachexia

Roberts, B. M., Ahn, B., Smuder, A. J., Al‐Rajhi, M., Gill, L., Beharry, A. W., Powers, S. K., Fuller, D. D., Ferreira, L. F., & Judge, A. R. (2013) · The FASEB Journal · doi:10.1096/fj.12-222844 · Cited by 108 · see citing works

Mechano-regulated Tenascin-C orchestrates muscle repair

Flück, M., Mund, S. I., Schittny, J. C., Klossner, S., Durieux, A., & Giraud, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805365105 · Cited by 100 · see citing works

Mice Lacking Homer 1 Exhibit a Skeletal Myopathy Characterized by Abnormal Transient Receptor Potential Channel Activity

Stiber, J. A., Zhang, Z.-S., Burch, J. L., Eu, J. P., Zhang, S., Truskey, G. A., Seth, M., Yamaguchi, N., Meissner, G., Shah, R. N., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01601-07 · Cited by 98 · see citing works

Cancer cachexia decreases specific force and accelerates fatigue in limb muscle

Roberts, B. M., Frye, G. S., Ahn, B., Ferreira, L. F., & Judge, A. R. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.018 · Cited by 89 · see citing works

Using GenePattern for Gene Expression Analysis

Kuehn, H., Liberzon, A., Reich, M. M., & Mesirov, J. P. (2008) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0712s22 · Cited by 87 · see citing works

FOXO3a Induces Differentiation of Bcr-Abl-transformed Cells through Transcriptional Down-regulation of Id1

Birkenkamp, K. U., Essafi, A., van der Vos, K. E., Costa, M. D., Hui, R. C.-Y., Holstege, F. C. P., Koenderman, L., Lam, E. W. ‐., & Coffer, P. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606669200 · Cited by 83 · see citing works

Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes

Ito, Y., Daitoku, H., & Fukamizu, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.043 · Cited by 78 · see citing works

Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice

Cm, L., Yang, Z., Liu, C.-W., Wang, R., Tien, P., Dale, R., & Sun, L.-Q. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701091 · Cited by 78 · see citing works

Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance

Dellett, M., Hu, W., Papadaki, V., & Ohnuma, S. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2012.01339.x · Cited by 77 · see citing works

Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting

Shum, A. M. Y., Mahendradatta, T., Taylor, R., Painter, A., Moore, M. M., Tsoli, M., Tan, T. C., Clarke, S. J., Robertson, G. R., & Polly, P. (2012) · Aging · doi:10.18632/aging.100436 · Cited by 77 · see citing works

Intrapleural Administration of AAV9 Improves Neural and Cardiorespiratory Function in Pompe Disease

Falk, D. J., Mah, C. S., Soustek, M. S., Lee, K., ElMallah, M. K., Cloutier, D. A., Fuller, D. D., & Byrne, B. J. (2013) · Molecular Therapy · doi:10.1038/mt.2013.96 · Cited by 72 · see citing works

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program

Choi, M.-C., Cohen, T. J., Barrientos, T., Wang, B., Li, M., Simmons, B. J., Yang, J. S., Cox, G. A., Zhao, Y., & Yao, T. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.025 · Cited by 71 · see citing works

Long-term Skeletal Muscle Protection After Gene Transfer in a Mouse Model of LGMD-2D

Pacak, C. A., Walter, G. A., Gaidosh, G., Bryant, N. D., Lewis, M. A., Germain, S. A., Mah, C. S., Campbell, K. P., & Byrne, B. J. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300246 · Cited by 53 · see citing works

C26 Cancer-Induced Muscle Wasting Is IKKβ-Dependent and NF-kappaB-Independent

Cornwell, E. W., Mirbod, A., Wu, C., Kandarian, S. C., & Jackman, R. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087776 · Cited by 42 · see citing works

Ubiquilin at a crossroads in protein degradation pathways

Rothenberg, C., & Monteiro, M. J. (2010) · Autophagy · doi:10.4161/auto.6.7.13118 · Cited by 40 · see citing works

The AP‐1/CJUN signaling cascade is involved in muscle differentiation: Implications in muscle wasting during cancer cachexia

Moore‐Carrasco, R., Garcia‐Martínez, C., Busquets, S., Ametller, E., Barreiro, E., López-Soriano, F. J., & Argilés, J. M. A. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.084 · Cited by 34 · see citing works

Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle cachexia

Skorokhod, A., Bachmann, J., Giese, N. A., Martignoni, M. E., & Krakowski‐Roosen, H. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-265 · Cited by 27 · see citing works

Elevated nuclear Foxo1 suppresses excitability of skeletal muscle fibers

Hernández‐Ochoa, E. O., Schachter, T. N., & Schneider, M. F. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00003.2013 · Cited by 8 · see citing works

Mitochondrial quality control and muscle mass maintenance.

Romanello, V., & Sandri, M. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2015.00422 · Cited by 434 · see citing works

Cancer cachexia: molecular mechanisms and treatment strategies

Setiawan, T., Sari, I. N., Wijaya, Y., Julianto, N. M., Muhammad, J. A., Lee, H.-Y., Ji, H.-O.-C., & Kwon, H. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01454-0 · Cited by 300 · see citing works

Skeletal Muscle Wasting and Renewal: A Pivotal Role of Myokine IL-6

Belizário, J. E., Fontes-Oliveira, C. C., Borges, J. P., Kashiabara, J. A., & Vannier, E. (2016) · SpringerPlus · doi:10.1186/s40064-016-2197-2 · Cited by 244 · see citing works

STAT3 in the Systemic Inflammation of Cancer Cachexia

Zimmers, T., Fishel, M., & Bonetto, A. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.02.009 · Cited by 216 · see citing works

Signaling Pathways That Control Muscle Mass

Vainshtein, A., & Sandri, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134759 · Cited by 213 · see citing works

The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass

Romanello, V., & Sandri, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03662-0 · Cited by 197 · see citing works

Modeling Human Cancer-induced Cachexia

Talbert, E. E., Cuitiño, M. C., Ladner, K. J., Rajasekerea, P. V., Siebert, M., Shakya, R., Leone, G. W., Ostrowski, M. C., Paleo, B. J., Weisleder, N. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.016 · Cited by 149 · see citing works

The JAK/STAT Pathway in Skeletal Muscle Pathophysiology

Moresi, V., Adamo, S., & Berghella, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00500 · Cited by 141 · see citing works

Protein breakdown in cancer cachexia

Sandri, M. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.11.002 · Cited by 134 · see citing works

A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia

Seto, D. N., Kandarian, S. C., & Jackman, R. W. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.638411 · Cited by 123 · see citing works

Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia

Bohnert, K. R., Gallot, Y. S., Sato, S., Xiong, G., Hindi, S. M., & Kumar, A. (2016) · The FASEB Journal · doi:10.1096/fj.201600250rr · Cited by 122 · see citing works

Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity

Hyatt, H. W., & Powers, S. K. (2021) · Antioxidants · doi:10.3390/antiox10040588 · Cited by 127 · see citing works

Molecular mechanisms of cancer cachexia‐related loss of skeletal muscle mass: data analysis from preclinical and clinical studies

Martin, A., Gallot, Y. S., & Freyssenet, D. (2023) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.13073 · Cited by 103 · see citing works

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Bonetto, A., Rupert, J. E., Barreto, R., & Zimmers, T. A. (2016) · Journal of Visualized Experiments · doi:10.3791/54893 · Cited by 113 · see citing works

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival

Segatto, M., Fittipaldi, R., Pin, F., Sartori, R., Dae Ko, K., Zare, H., Fenizia, C., Zanchettin, G., Pierobon, E. S., Hatakeyama, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01645-7 · Cited by 101 · see citing works

Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies

Martin, A., & Freyssenet, D. G. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12678 · Cited by 97 · see citing works

Tumour‐derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour‐bearing mice

Kandarian, S. C., Nosacka, R. L., Delitto, A. E., Judge, A. R., Judge, S. M., Ganey, J. D., Moreira, J. D., & Jackman, R. W. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12346 · Cited by 94 · see citing works

Skeletal muscle fibrosis in pancreatic Cancer patients with respect to survival

Judge, S. M., Nosacka, R. L., Delitto, D., Gerber, M. H., Cameron, M. E., Trevino, J. G., & Judge, A. R. (2018) · JNCI Cancer Spectrum · doi:10.1093/jncics/pky043 · Cited by 91 · see citing works

A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice

Hunt, L. C., Stover, J., Haugen, B., Shaw, T. I., Li, Y., Pagala, V. R., Finkelstein, D., Barton, E. R., Fan, Y., Labelle, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.094 · Cited by 90 · see citing works

Cancer-induced cardiac cachexia: Pathogenesis and impact of physical activity

Belloum, Y., Rannou‐Bekono, F., & Favier, F. B. (2017) · Oncology Reports · doi:10.3892/or.2017.5542 · Cited by 90 · see citing works

Mitochondrial dynamics in cancer-induced cachexia

van der Ende, M., Grefte, S., Plas, R., Meijerink, J., Witkamp, R. F., Keijer, J., & van Norren, K. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.008 · Cited by 87 · see citing works

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia

Pin, F., Novinger, L. J., Huot, J. R., Harris, R. A., Couch, M. E., O'Connell, T. M., & Bonetto, A. (2019) · The FASEB Journal · doi:10.1096/fj.201802799r · Cited by 81 · see citing works

Activation of Akt–mTORC1 signalling reverts cancer‐dependent muscle wasting

Geremia, A., Sartori, R., Baraldo, M., Nogara, L., Balmaceda, V., Dumitras, A. G., Ciciliot, S., Scalabrin, M., Nolte, H., & Blaauw, B. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12854 · Cited by 75 · see citing works

Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice

Re Cecconi, A. D., Forti, M., Chiappa, M., Zhu, Z., Zingman, L. V., Cervo, L., Beltrame, L., Marchini, S., & Piccirillo, R. (2019) · Cancers · doi:10.3390/cancers11101541 · Cited by 66 · see citing works

New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss

Johns, N., Stretch, C., Tan, B. H. L., Solheim, T. S., Sørhaug, S., Stephens, N. A., Gioulbasanis, I., Skipworth, R. J. E., Deans, D. A. C., Vigano, A. A. L., et al. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12138 · Cited by 66 · see citing works

Molecular mechanisms of cancer cachexia‑induced muscle atrophy (Review)

Yang, W., Huang, J., Wu, H., Wang, Y., Du, Z., Ling, Y., Wang, W., Wu, Q., & Gao, W. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11608 · Cited by 64 · see citing works

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

Ebert, S. M., Bullard, S. A., Basisty, N., Marcotte, G. R., Skopec, Z. P., Dierdorff, J. M., Al‐Zougbi, A., Tomcheck, K. C., DeLau, A. D., Rathmacher, J. A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012095 · Cited by 63 · see citing works

The Impact of Immune Cells on the Skeletal Muscle Microenvironment During Cancer Cachexia

VanderVeen, B. N., Murphy, E. A., & Carson, J. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01037 · Cited by 52 · see citing works

IL-8 Released from Human Pancreatic Cancer and Tumor-Associated Stromal Cells Signals through a CXCR2-ERK1/2 Axis to Induce Muscle Atrophy

Callaway, C. S., Delitto, A. E., D’Lugos, A. C., Patel, R., Nosacka, R. L., Delitto, D., Deyhle, M. R., Trevino, J. G., Judge, S. M., & Judge, A. R. (2019) · Cancers · doi:10.3390/cancers11121863 · Cited by 61 · see citing works

Regulation of glucose uptake and inflammation markers by FOXO1 and FOXO3 in skeletal muscle

Lundell, L. S., Massart, J., Altıntaş, A., Krook, A., & Zierath, J. R. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.09.011 · Cited by 55 · see citing works

MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer

Judge, S. M., Deyhle, M. R., Neyroud, D., Nosacka, R. L., D’Lugos, A. C., Cameron, M. E., Vohra, R., Smuder, A. J., Roberts, B. M., Callaway, C. S., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1558 · Cited by 53 · see citing works

The Toll-Like Receptor/MyD88/XBP1 Signaling Axis Mediates Skeletal Muscle Wasting during Cancer Cachexia

Bohnert, K. R., Goli, P., Roy, A., Sharma, A. K., Xiong, G., Gallot, Y. S., & Kumar, A. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00184-19 · Cited by 52 · see citing works

Therapeutic Consequences of Targeting the IGF-1/PI3K/AKT/FOXO3 Axis in Sarcopenia: A Narrative Review

Gellhaus, B., Böker, K. O., Schilling, A. F., & Saul, D. (2023) · Cells · doi:10.3390/cells12242787 · Cited by 51 · see citing works

Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer‐induced cachexia

Vaes, R. D. W., van Dijk, D. P. J., Welbers, T. T. J., Blok, M. J., Aberle, M. R., Heij, L. R., Boj, S. F., Damink, S. W. M. O., & Rensen, S. S. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12627 · Cited by 46 · see citing works

Glucocorticoid-Mediated Skeletal Muscle Atrophy: Molecular Mechanisms and Potential Therapeutic Targets

Permpoon, U., Moon, J., Kim, C. Y., & Nam, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157616 · Cited by 52 · see citing works

A clinically applicable muscular index predicts long-term survival in resectable pancreatic cancer

Delitto, D., Judge, S. M., George, T. J., Sarosi, G. A., Thomas, R. M., Behrns, K. E., Hughes, S. J., Judge, A. R., & Trevino, J. G. (2016) · Surgery · doi:10.1016/j.surg.2016.09.038 · Cited by 46 · see citing works

Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia

de Moraes, L. N., Fernández, G. J., Vechetti, I. J., Freire, P. P., de Souza, R. W. A., Villacis, R. A. R., Rogatto, S. R., Reis, P. P., Dal‐Pai‐Silva, M., & Carvalho, R. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-07236-2 · Cited by 45 · see citing works

Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment

Okada, R., Fujita, S.-I., Suzuki, R., Hayashi, T., Tsubouchi, H., Kato, C., Sadaki, S., Kanai, M., Fuseya, S., Inoue, Y., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88392-4 · Cited by 46 · see citing works

IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway

Liu, D., Qiao, X., Ge, Z., Shang, Y., Li, Y., Wang, W., Chen, M., Si, S., & Chen, S. (2019) · Skeletal Muscle · doi:10.1186/s13395-019-0193-2 · Cited by 42 · see citing works

Distinct cachexia profiles in response to human pancreatic tumours in mouse limb and respiratory muscle

Nosacka, R. L., Delitto, A. E., Delitto, D., Patel, R., Judge, S. M., Trevino, J. G., & Judge, A. R. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12550 · Cited by 42 · see citing works

Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth

Neyroud, D., Laitano, O., Dasgupta, A., Lopez, C., Schmitt, R. E., Schneider, J. Z., Hammers, D. W., Sweeney, H. L., Walter, G. A., Doles, J. D., et al. (2023) · Communications Biology · doi:10.1038/s42003-023-04902-2 · Cited by 41 · see citing works

Human pancreatic cancer xenografts recapitulate key aspects of cancer cachexia

Delitto, D., Judge, S. M., Delitto, A. E., Nosacka, R. L., Rocha, F. R. G., DiVita, B. B., Gerber, M. H., George, T. J., Behrns, K. E., Hughes, S. J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13593 · Cited by 40 · see citing works

Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds

Criado‐Mesas, L., Ballester, M., Crespo‐Piazuelo, D., Castelló, A., Fernández, A. I., & Folch, J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67015-4 · Cited by 40 · see citing works

FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness

Neyroud, D., Nosacka, R. L., Callaway, C. S., Trevino, J. G., Hu, H., Judge, S. M., & Judge, A. R. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12666 · Cited by 35 · see citing works

Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia

Shum, A. M. Y., Fung, D. C. Y., Corley, S., McGill, M. C., Bentley, N. L., Tan, T. C., Wilkins, M. R., & Polly, P. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00128.2014 · Cited by 38 · see citing works

Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content

Neyroud, D., Nosacka, R. L., Judge, A. R., & Hepple, R. T. (2019) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-019-09510-4 · Cited by 35 · see citing works

The role of IL-1 in adipose browning and muscle wasting in CKD-associated cachexia

Cheung, W. W., Zheng, R., Sheng, H., Wang, Z., Gonzalez, A., Zhou, P. H., Hoffman, H. M., & MAK, R. H. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-94565-y · Cited by 33 · see citing works

UBR2 targets myosin heavy chain IIb and IIx for degradation: Molecular mechanism essential for cancer-induced muscle wasting

Gao, S., Zhang, G., Zhang, Z., Zhu, J. Z., Li, L., Zhou, Y., Rodney, G. G., Abo‐Zahrah, R., Anderson, L. J., Garcia, J. M., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200215119 · Cited by 31 · see citing works

Development of ovarian tumour causes significant loss of muscle and adipose tissue: a novel mouse model for cancer cachexia study

Luan, Y., Zhang, Y., Yu, S., You, M., Xu, P. C., Chung, S., Kurita, T., Zhu, J., & Kim, S. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12864 · Cited by 31 · see citing works

MicroRNA-mRNA Co-sequencing Identifies Transcriptional and Post-transcriptional Regulatory Networks Underlying Muscle Wasting in Cancer Cachexia

Fernández, G. J., Ferreira, J. H., Vechetti, I. J., de Moraes, L. N., Cury, S. S., Freire, P. P., Gutiérrez, J., Ferretti, R., Dal‐Pai‐Silva, M., Rogatto, S. R., et al. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00541 · Cited by 29 · see citing works

Omics/systems biology and cancer cachexia

Gallagher, I. J., Jacobi, C., Tardif, N., Rooyackers, O., & Fearon, K. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.12.022 · Cited by 27 · see citing works

A large-scale transgenic RNAi screen identifies transcription factors that modulate myofiber size in Drosophila

Graça, F. A., Sheffield, N., Puppa, M., Finkelstein, D., Hunt, L. C., & Demontis, F. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009926 · Cited by 28 · see citing works

REDD1 deletion attenuates cancer cachexia in mice

Hain, B. A., Xu, H., VanCleave, A. M., Gordon, B. S., Kimball, S. R., & Waning, D. L. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00536.2021 · Cited by 24 · see citing works

Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting

Kunz, H., Dorschner, J. M., Berent, T. E., Meyer, T., Wang, X., Jatoi, A., Kumar, R., & Lanza, I. R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014884 · Cited by 23 · see citing works

JAK/STAT inhibition augments soleus muscle function in a rat model of critical illness myopathy via regulation of complement C3/3R

Addinsall, A. B., Cacciani, N., Akkad, H., Salah, H. A., Tchkonia, T., Kirkland, J. L., & Larsson, L. (2021) · The Journal of Physiology · doi:10.1113/jp281220 · Cited by 23 · see citing works

Unexpected ribosomal DNA internal transcribed spacer sequence variation within Erysiphe aquilegiae sensu lato

Cunnington, J. H., Lawrie, A. C., & Pascoe, I. G. (2004) · RMIT Research Repository (RMIT University Library) · Cited by 22 · see citing works

Thyrotroph embryonic factor is downregulated in bladder cancer and suppresses proliferation and tumorigenesis via the AKT/FOXOs signalling pathway

Yang, J., Wang, B., Chen, H., Chen, X., Li, J., Chen, Y., Yuan, D., & Zheng, S. (2018) · Cell Proliferation · doi:10.1111/cpr.12560 · Cited by 21 · see citing works

Cancer Takes a Toll on Skeletal Muscle by Releasing Heat Shock Proteins—An Emerging Mechanism of Cancer-Induced Cachexia

Sin, T. K., Zhang, G., Zhang, Z., Gao, S., Li, M., & Li, Y. (2019) · Cancers · doi:10.3390/cancers11091272 · Cited by 22 · see citing works

Emerging Mechanisms of Skeletal Muscle Homeostasis and Cachexia: The SUMO Perspective

Khan, B., Gand, L. V., Amrute‐Nayak, M., & Nayak, A. (2023) · Cells · doi:10.3390/cells12040644 · Cited by 19 · see citing works

Foxo3 Knockdown Mediates Decline of Myod1 and Myog Reducing Myoblast Conversion to Myotubes

Gellhaus, B., Böker, K. O., Gsaenger, M., Rodenwaldt, E., Hüser, M. A., Schilling, A. F., & Saul, D. (2023) · Cells · doi:10.3390/cells12172167 · Cited by 19 · see citing works

Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia

Massart, I. S., Paulissen, G., Loumaye, A., Lause, P., Pötgens, S. A., Thibaut, M. M., Balan, E., Deldicque, L., Atfi, A., Louis, E. J., et al. (2020) · Cancers · doi:10.3390/cancers12113221 · Cited by 19 · see citing works

Molecular Basis for the Therapeutic Effects of Exercise on Mitochondrial Defects

Memme, J. M., & Hood, D. A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.615038 · Cited by 19 · see citing works

FoxO3a suppression and VPS34 activity are essential to anti-atrophic effects of leucine in skeletal muscle

Baptista, I. L., Silvestre, J. G., Silva, W. J., Labeit, S., & Moriscot, A. S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2614-z · Cited by 19 · see citing works

Involvement of the gut microbiota in cancer cachexia

VanderVeen, B. N., Cardaci, T. D., Bullard, B. M., Madden, M., Li, J., Velázquez, K. T., Kubinak, J. L., Fan, D., & Murphy, E. A. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00327.2024 · Cited by 18 · see citing works

Translational research on Myology and Mobility Medicine: 2021 semi-virtual PDM3 from Thermae of Euganean Hills, May 26 - 29, 2021

Carraro, U., & Yablonka‐Reuveni, Z. (2021) · European Journal of Translational Myology · doi:10.4081/ejtm.2021.9743 · Cited by 17 · see citing works

TSC/mTORC1 mediates mTORC2/AKT1 signaling in c-MYC–induced murine hepatocarcinogenesis via centromere protein M

Zhou, Y., Zhang, S., Qiu, G., Wang, X., Yonemura, A., Xu, H., Cui, G., Deng, S., Chun, J., Chen, N., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci174415 · Cited by 16 · see citing works

Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia model

Dark, C., Ali, N., Golenkina, S., Dhyani, V., Blazev, R., Parker, B. L., Murphy, K. T., Lynch, G. S., Senapati, T., Millard, S. S., et al. (2024) · EMBO Reports · doi:10.1038/s44319-024-00102-z · Cited by 16 · see citing works

Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia

Rosa-Caldwell, M. E., Benson, C. A., Lee, D. E., Brown, J. L., Washington, T. A., Greene, N. P., & Wiggs, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217841 · Cited by 13 · see citing works

Do neurogenic and cancer-induced muscle atrophy follow common or divergent paths?

Bouché, M., Lozanoska‐Ochser, B., Proietti, D., & Madaro, L. (2018) · European Journal of Translational Myology · doi:10.4081/ejtm.2018.7931 · Cited by 13 · see citing works

The E3 ligase UBR2 regulates cell death under caspase deficiency via Erk/MAPK pathway

Villa, E., Paul, R., Meynet, O., Volturo, S., Pinna, G., & Ricci, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03258-3 · Cited by 12 · see citing works

Defining and Addressing Research Priorities in Cancer Cachexia through Transdisciplinary Collaboration

Park, M. A., Whelan, C. J., Ahmed, S., Boeringer, T., Brown, J. S., Carson, T., Crowder, S. L., Gage, K. L., Gregg, C. J., Jeong, D. K., et al. (2024) · Cancers · doi:10.3390/cancers16132364 · Cited by 12 · see citing works

Moderating AKT signaling with baicalein protects against weight loss by preventing muscle atrophy in a cachexia model caused by CT26 colon cancer

Song, G., Park, W. Y., Jiao, W., Park, J. Y., Jung, S. J., Ma, S., Lee, J., Lee, K. Y., Choe, S., Park, J., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2024.119670 · Cited by 12 · see citing works

The regulation of Akt and FoxO transcription factors during dehydration in the African clawed frog (Xenopus laevis)

Luu, B. E., Zhang, Y., & Storey, K. B. (2020) · Cell Stress and Chaperones · doi:10.1007/s12192-020-01123-y · Cited by 12 · see citing works

Exercise-modulated IL-6 in cancer cachexia: molecular mechanisms and therapeutic potential

Wei, S., Lv, X., Xu, Y., & Ding, S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07690-5 · Cited by 11 · see citing works

Targeting Epigenetic Regulators with HDAC and BET Inhibitors to Modulate Muscle Wasting

Nevi, L., Pöllänen, N., Penna, F., & Caretti, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216404 · Cited by 11 · see citing works

Effects of prostate cancer and exercise training on left ventricular function and cardiac and skeletal muscle mass

Baumfalk, D. R., Opoku‐Acheampong, A. B., Caldwell, J. T., Ade, C. J., Copp, S. W., Musch, T. I., & Behnke, B. J. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00829.2018 · Cited by 11 · see citing works

Normobaric hypoxia shows enhanced FOXO1 signaling in obese mouse gastrocnemius muscle linked to metabolism and muscle structure and neuromuscular innervation

Song, J., Duivenvoorde, L. P. M., Grefte, S., Kuda, O., Martínez-Ramírez, F., van der Stelt, I., Mastorakou, D., van Schothorst, E. M., & Keijer, J. (2023) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-023-02854-4 · Cited by 9 · see citing works

Biological sex divergence in transcriptomic profiles during the onset of hindlimb unloading-induced atrophy

Tsitkanou, S., da Silva, F. M., Cabrera, A. R., Schrems, E. R., Murach, K. A., Washington, T. A., Rosa‐Caldwell, M. E., & Greene, N. P. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00352.2023 · Cited by 8 · see citing works

Effect of 11-Deoxycorticosterone in the Transcriptomic Response to Stress in Rainbow Trout Skeletal Muscle

Zuloaga, R., Aravena-Canales, D., Aedo, J. E., Osorio‐Fuentealba, C., Molina, A., & Valdés, J. A. (2023) · Genes · doi:10.3390/genes14020512 · Cited by 8 · see citing works

Immunosenescence in skeletal muscle: The role-play in cancer cachexia chessboard

Giovarelli, M., Mocciaro, E., Carnovale, C., Cervia, D., Perrotta, C., & Clementi, E. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.02.012 · Cited by 8 · see citing works

RNA sequencing reveals potential interacting networks between the altered transcriptome and ncRNome in the skeletal muscle of diabetic mice

Kesharwani, D., Kumar, A., Poojary, M., Scaria, V., & Datta, M. (2021) · Bioscience Reports · doi:10.1042/bsr20210495 · Cited by 9 · see citing works

Eicosapentaenoic Acid‐Enriched Phospholipids Alleviate Skeletal Muscle Atrophy in Lewis Lung Carcinoma Mouse Model

Wu, Z., Li, W., Yang, Y., Zheng, Y., Zhou, M., Li, Y., Li, H. Z., Wu, H., & Du, L. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300033 · Cited by 8 · see citing works

Modulating phosphatase DUSP22 with BML-260 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression

Lee, S. H., Kim, H., Kim, S.-W., Lee, H., Jung, D., & Williams, D. R. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00234-2 · Cited by 6 · see citing works

Effects of high-intensity training on prostate cancer-induced cardiac atrophy.

Baumfalk, D. R., Opoku‐Acheampong, A. B., Caldwell, J. T., Butenas, A. L. E., Horn, A. G., Kunkel, O. N., Copp, S. W., Ade, C. J., Musch, T. I., & Behnke, B. J. (2021) · Europe PMC (PubMed Central) · Cited by 7 · see citing works

Single‐Cell RNA‐Sequencing Reveals Cachectic Satellite Cell Population in Muscle of Male Mice With Cancer Cachexia

Brown, A., Collao, N., Saleh, A., Strong, N., Lisio, M. D., & Wiper‐Bergeron, N. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70260 · Cited by 5 · see citing works

Role of myofiber-specific FoxP1 in pancreatic cancer-induced muscle wasting

Schonk, M. M., Ducharme, J. B., Neyroud, D., Nosacka, R. L., Tucker, H. O., Judge, S. M., & Judge, A. R. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00701.2024 · Cited by 5 · see citing works

Resistance-Based Muscle Therapy, Frailty, and Muscle Biopsy Findings in Kidney Transplant Candidates: A Clinical Trial

Bartlett, S. T., Santi, I., Hachaj, G., Wilund, K. R., Tzvetanov, I. G., Spaggiari, M., Almario, J., Cocco, P. D., Bianco, F. M., Hajjiri, Z., et al. (2025) · Kidney Medicine · doi:10.1016/j.xkme.2025.100978 · Cited by 3 · see citing works

Leucine and Its Importance for Cell Signalling Pathways in Cancer Cachexia-Induced Muscle Wasting

de Oliveira, A. G., Cruz, B., de Oliveira, S. C. P., Viana, L. R., Miyaguti, N. A. D. S., Ramos, L., Valentim, R. R., & Gomes‐Marcondes, M. C. C. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.78990 · Cited by 3 · see citing works

Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine

Hesketh, S. J. (2024) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2024.01.006 · Cited by 2 · see citing works

Cancer Cachexia

Puppa, M., & Carson, J. A. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-88361-3_12 · Cited by 2 · see citing works

Animal models of cancer-associated cachexia

Shukla, S. K., & Singh, P. K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814704-7.00001-5 · Cited by 2 · see citing works

Mitochondrial fusion and altered beta-oxidation drive muscle wasting in a Drosophila cachexia modelPreprint

Dark, C., Ali, N., Golenkina, S., Blazev, R., Parker, B. L., Murphy, K., Lynch, G. S., Senapati, T., Millard, S. S., Judge, S. M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.23.546217 · Cited by 2 · see citing works

An alternative pocket for binding the N‐degrons by the UBR1 and UBR2 ubiquitin E3 ligases

Huang, S., Chen, D., Ren, T., Thomas, N., Wu, J., Sankaran, B., Jones, R., Taylor, S. S., & Chen, Y. (2025) · Protein Science · doi:10.1002/pro.70248 · Cited by 1 · see citing works

Tumor-Secreted ADAMTSL4 Activates Latent TGFβ1 to Drive Cancer Cachexia

Machado, J., Karthikaisamy, V., Mohr, H., Kaltenecker, D., Benedikt, P., Morigny, P., Mhamane, A., Geppert, J., Fumo, A. R., Haase, K., et al. (2026) · Cancer Discovery · doi:10.1158/2159-8290.cd-26-0045 · Cited by 1 · see citing works

Relevance of cancer cachexia models – muscle whole genome gene expression in human and animal cachexiaPreprint

Plas, R. L. C., Hooiveld, G. J. E. J., Witkamp, R. F., & van Norren, K. (2020) · Research Square · doi:10.21203/rs.3.rs-56696/v1 · Cited by 1 · see citing works

Blocking muscle wasting via deletion of the muscle-specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growthPreprint

Neyroud, D., Laitano, O., Dasgupta, A., Lopez, C., Schmitt, R. E., Schneider, J., Hammers, D. W., Sweeney, H. L., Walter, G. A., Doles, J. D., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2524562/v1 · Cited by 1 · see citing works

Unfolded protein response pathways in skeletal muscle homeostasis.

Bohnert, K. R. (2018) · doi:10.18297/etd/3033

What moves wasting muscle? : Cancer cachexia; treatment, targets and translation

Plas, R. L. C. (2019) · doi:10.18174/502585

Stage-specific muscle wasting mechanisms in a novel cancer cachexia mouse model for ovarian granulosa cell tumorPreprint

Zhang, Y., Zhu, J., Kim, S., Romero, M. M., Even, K. A., Kurita, T., & Woodruff, T. K. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.16.154385

Faculty Opinions recommendation of The impact of immune cells on the skeletal muscle microenvironment during cancer cachexia.

Ji, L. L. (2021) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738789048.793582075

RESEARCH ARTICLE Open Access Genome-wide identification of FoxO-dependent

K, S. C., & Judge, A. R. (2016)

FoxP1 is a transcriptional repressor associated with cancer cachexia that induces skeletal muscle wasting and weakness

Neyroud, D., Nosacka, R. L., Callaway, C. S., Trevino, J. G., Hu, H., Judge, S. M., & Judge, A. R. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12666 · Cited by 35 · see citing works

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

Reed, S. A., Sandesara, P. B., Judge, S. M., & Judge, A. R. (2011) · The FASEB Journal · doi:10.1096/fj.11-189977 · Cited by 224 · see citing works

Foxo Activity is Required for the Normal Muscle Atrophy Program during Cancer Induced Cachexia

Reed, S. A., Sandesara, P. B., & Judge, A. R. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389378.72557.97 · Cited by 1 · see citing works

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia

Ducharme, J. B., Neyroud, D., Schonk, M. M., Gutierrez‐Monreal, M. A., Huo, Z., Tucker, H. O., Esser, K. A., Judge, S. M., & Judge, A. R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115689 · Cited by 9 · see citing works