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Dendritic Cells: Critical Regulators of Allergic Asthma

Morianos, Ioannis, Semitekolou, Maria·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21217930PMC PMC7663753
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Abstract

Allergic asthma is a chronic inflammatory disease of the airways characterized by airway hyperresponsiveness (AHR), chronic airway inflammation, and excessive T helper (Th) type 2 immune responses against harmless airborne allergens. Dendritic cells (DCs) represent the most potent antigen-presenting cells of the immune system that act as a bridge between innate and adaptive immunity. Pertinent to allergic asthma, distinct DC subsets are known to play a central role in initiating and maintaining allergen driven Th2 immune responses in the airways. Nevertheless, seminal studies have demonstrated that DCs can also restrain excessive asthmatic responses and thus contribute to the resolution of allergic airway inflammation and the maintenance of pulmonary tolerance. Notably, the transfer of tolerogenic DCs in vivo suppresses Th2 allergic responses and protects or even reverses established allergic airway inflammation. Thus, the identification of novel DC subsets that possess immunoregulatory properties and can efficiently control aberrant asthmatic responses is critical for the re-establishment of tolerance and the amelioration of the asthmatic disease phenotype.

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Figure 1 Innate and adaptive type 2 immunity during allergic airway inflammation.
Figure 1 Innate and adaptive type 2 immunity during allergic airway inflammation.CC BY · PubMed Central
Figure 2 The location and function of different DC subsets in the airways.
Figure 2 The location and function of different DC subsets in the airways.CC BY · PubMed Central
Figure 3 Act-A-iTreg-modified DCs control allergic asthma through the instruction of CD4+Foxp3+ regulatory T cells.
Figure 3 Act-A-iTreg-modified DCs control allergic asthma through the instruction of CD4+Foxp3+ regulatory T cells.CC BY · PubMed Central

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Metadata

Authors
Morianos, I., & Semitekolou, M.
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-10-26
Volume
21
Issue
21
Pages
7930
ISSN
1422-0067
DOI
10.3390/ijms21217930
PMC
PMC7663753
Cited by
102
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Hellenic Foundation for Research and Innovation (1030)

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