The DOI matches its Crossref record; 223 of the 223 references it cites were found in a registry or an index.
Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements
Open accessAbstract
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause of cancer-related mortality rates worldwide. Although modern research was able to shed light on the pathogenesis of CRC and provide enhanced screening strategies, the prevalence of CRC is still on the rise. Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, analyzing signaling pathways involved in CRC metastasis is necessary to elucidate the underlying mechanism of CRC progression and pharmacotherapy. This review focused on target genes as well as various cellular signaling pathways including Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF, and JAKs/STAT3, which are associated with CRC progression and metastasis. Additionally, alternations in methylation patterns in relation with signaling pathways involved in regulating various cellular mechanisms such as cell cycle, transcription, apoptosis, and angiogenesis as well as invasion and metastasis were also reviewed. To date, understanding the genomic and epigenomic instability has identified candidate biomarkers that are validated for routine clinical use in CRC management. Nevertheless, better understanding of the onset and progression of CRC can aid in the development of early detection molecular markers and risk stratification methods to improve the clinical care of CRC patients.
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Cited by
Hossain, M. S., Karuniawati, H., Jairoun, A. A., Urbi, Z., Ooi, D. J., John, A., Lim, Y. C., Kibria, K. M. K., Mohiuddin, A. K. M., Ming, L. C., et al. (2022) · Cancers · doi:10.3390/cancers14071732 · Cited by 920
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Clinical management of metastatic colorectal cancer in the era of precision medicine
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Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review
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Plant-derived bioactive compounds in colon cancer treatment: An updated review
Esmeeta, A., Adhikary, S., Dharshnaa, V., Swarnamughi, P., Ummul Maqsummiya, Z., Banerjee, A., Pathak, S., & Duttaroy, A. K. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113384 · Cited by 293
Metadata
- Authors
- Malki, A., ElRuz, R. A., Gupta, I., Allouch, A., Vranic, S., & Al Moustafa, A.-E.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2020-12-24
- Volume
- 22
- Issue
- 1
- Pages
- 130
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3117886022
- Cited by
- 398
- References
- 223
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- gold
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- Malki, A., ElRuz, R. A., Gupta, I., Allouch, A., Vranic, S., & Al Moustafa, A.-E. (2020). Molecular Mechanisms of Colon Cancer Progression and Metastasis: Recent Insights and Advancements. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22010130
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
