The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Glutathione in the Brain
Open accessAbstract
Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH depletion in the brain is a common finding in patients with neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, and can cause neurodegeneration prior to disease onset. Excitatory amino acid carrier 1 (EAAC1), a sodium-dependent glutamate/cysteine transporter that is selectively present in neurons, plays a central role in the regulation of neuronal GSH production. The expression of EAAC1 is posttranslationally controlled by the glutamate transporter-associated protein 3–18 (GTRAP3-18) or miR-96-5p in neurons. The regulatory mechanism of neuronal GSH production mediated by EAAC1 may be a new target in therapeutic strategies for these neurodegenerative diseases. This review describes the regulatory mechanism of neuronal GSH production and its potential therapeutic application in the treatment of neurodegenerative diseases.
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Cites
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Mitochondria at the crossroads of health and disease
Suomalainen, A., & Nunnari, J. (2024) · Cell · doi:10.1016/j.cell.2024.04.037 · Cited by 478
A Historical Review of Brain Drug Delivery
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Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies
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Glutathione and Related Molecules in Parkinsonism
Asanuma, M., & Miyazaki, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168689 · Cited by 68
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Metadata
- Authors
- Aoyama, K.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-05-09
- Volume
- 22
- Issue
- 9
- Pages
- 5010
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3161058384
- Cited by
- 336
- References
- 138
- FWCI
- 15.98
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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