The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
Role of Insulin in Health and Disease: An Update
Open accessAbstract
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose levels in the bloodstream and induces glucose storage in the liver, muscles, and adipose tissue, resulting in overall weight gain. The modulation of a wide range of physiological processes by insulin makes its synthesis and levels critical in the onset and progression of several chronic diseases. Although clinical and basic research has made significant progress in understanding the role of insulin in several pathophysiological processes, many aspects of these functions have yet to be elucidated. This review provides an update on insulin secretion and regulation, and its physiological roles and functions in different organs and cells, and implications to overall health. We cast light on recent advances in insulin-signaling targeted therapies, the protective effects of insulin signaling activators against disease, and recommendations and directions for future research.
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Cited by
Mechanisms of Oxidative Stress in Metabolic Syndrome
Masenga, S. K., Kabwe, L. S., Chakulya, M., & Kirabo, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097898 · Cited by 717
Burks, J. H., Joe, L., Kanjaria, K., Monsivais, C., O'laughlin, K., & Smarr, B. L. (2025) · PLOS Digital Health · doi:10.1371/journal.pdig.0000815 · Cited by 5
Metadata
- Authors
- Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M.-G.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-06-15
- Volume
- 22
- Issue
- 12
- Pages
- 6403
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3166559086
- Cited by
- 472
- References
- 168
- FWCI
- 49.78
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M.-G. (2021). Role of Insulin in Health and Disease: An Update. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22126403
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
