The DOI matches its Crossref record; 193 of the 193 references it cites were found in a registry or an index.
Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation
Open accessAbstract
Ageing and chronic degenerative pathologies demonstrate the shared characteristics of high bioavailability of reactive oxygen species (ROS) and oxidative stress, chronic/persistent inflammation, glycation, and mitochondrial abnormalities. Excessive ROS production results in nucleic acid and protein destruction, thereby altering the cellular structure and functional outcome. To stabilise increased ROS production and modulate oxidative stress, the human body produces antioxidants, “free radical scavengers”, that inhibit or delay cell damage. Reinforcing the antioxidant defence system and/or counteracting the deleterious repercussions of immoderate reactive oxygen and nitrogen species (RONS) is critical and may curb the progression of ageing and chronic degenerative syndromes. Various therapeutic methods for ROS and oxidative stress reduction have been developed. However, scientific investigations are required to assess their efficacy. In this review, we summarise the interconnected mechanism of oxidative stress and chronic inflammation that contributes to ageing and chronic degenerative pathologies, including neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), cardiovascular diseases CVD, diabetes mellitus (DM), and chronic kidney disease (CKD). We also highlight potential counteractive measures to combat ageing and chronic degenerative diseases.
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1 retracted
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Cited by
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases
Yang, J., Luo, J., Tian, X., Zhao, Y., Li, Y., & Wu, X. (2024) · Antioxidants · doi:10.3390/antiox13040394 · Cited by 259
Meng, Q., & Su, C.-H. (2024) · doi:10.20944/preprints202404.0770.v1 · Cited by 149
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications
Shanaida, M., Mykhailenko, O., Lysiuk, R., Hudz, N., Balwierz, R., Shulhai, A., Shapovalova, N., Shanaida, V., & Bjørklund, G. (2025) · Pharmaceuticals · doi:10.3390/ph18030403 · Cited by 62
Metadata
- Authors
- Leyane, T. S., Jere, S. W., & Houreld, N. N.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-06-30
- Volume
- 23
- Issue
- 13
- Pages
- 7273
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4283766083
- Cited by
- 469
- References
- 193
- FWCI
- 31.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation. https://app.cochat.ai/papers/10.3390/ijms23137273
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- Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022). Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms23137273
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
