Curcumin: A Review of Its Effects on Human Health
Open accessAbstract
Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.
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Higher dosages of curcumin are more efficacious than lower dosages, regardless of administration route.
“Regardless of the administration route, higher dosages have been determined to be more efficacious than lower dosages, and cognitive enhancement was more prominent when curcumin was administered with piperine, which has a plethora of pharmacological and positive health effects against chronic disorders [146].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [146]
Curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects.
“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [146]
Cognitive enhancement from curcumin is more prominent when curcumin is administered with piperine.
“Regardless of the administration route, higher dosages have been determined to be more efficacious than lower dosages, and cognitive enhancement was more prominent when curcumin was administered with piperine, which has a plethora of pharmacological and positive health effects against chronic disorders [146].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [146]
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- Authors
- Hewlings, S., & Kalman, D.
- Affiliations
- Central Michigan University (US)
- Nova Southeastern University (US)
- Corresponding author
- Hewlings, Susan
- Venue
- Foods
- Publisher
- MDPI AG
- Published
- 2017-10-22
- Volume
- 6
- Issue
- 10
- Pages
- 92
- ISSN
- 2304-8158 (ISSN-L)
- PMC
- PMC5664031
- OpenAlex
- W2766083858
- Cited by
- 2,720
- References
- 68
- Citations by year
- 2026: 336 · 2025: 364 · 2024: 383 · 2023: 399 · 2022: 415 · 2021: 380 · 2020: 258 · 2019: 125 · 2018: 54 · 2017: 1 · 2012: 2
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Foods (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
- Keywords
- curcumin, turmeric, polyphenols, bioavailability, piperine, antioxidant activity, anti-inflammatory activity, oxidative stress, metabolic syndrome, arthritis, anxiety, hyperlipidemia, exercise-induced inflammation, muscle soreness, post-exercise recovery
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