Albumin stimulates epithelial Na(+) transport and barrier integrity by activating the PI3K/AKT/SGK1 pathway

The antioxidant properties of serum albumin

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Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

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Distinct endocytotic pathways in epidermal growth factor-stimulated human carcinoma A431 cells [published erratum appears in J Cell Biol 1990 Mar;110(3):859]

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Regulation of membrane traffic by phosphoinositide 3-kinases

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Review article: albumin as a drug—biological effects of albumin unrelated to oncotic pressure

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Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule

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Albumin and Mammalian cell culture: implications for biotechnology applications

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Albondin-mediated capillary permeability to albumin. Differential role of receptors in endothelial transcytosis and endocytosis of native and modified albumins.

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Phosphoinositide 3‐kinase‐dependent activation of Rac

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Macropinocytosis in Different Cell Types: Similarities and Differences

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Decreased sodium ion absorption across nasal epithelium of very premature infants with respiratory distress syndrome

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Akt Mediates the Effect of Insulin on Epithelial Sodium Channels by Inhibiting Nedd4-2*

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Isolation and characterization of a cell surface albumin-binding protein from vascular endothelial cells.

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The origins and evolution of macropinocytosis

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Crossroads of PI3K and Rac pathways

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Mechanisms of alveolar protein clearance in the intact lung

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Insulin-stimulated trafficking of ENaC in renal cells requires PI 3-kinase activity

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Evidence for the role of alveolar epithelial gp60 in active transalveolar albumin transport in the rat lung

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Interaction of epithelial ion channels with the actin-based cytoskeleton

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Clathrin-mediated endocytosis of FITC-albumin in alveolar type II epithelial cell line RLE-6TN

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Adenovirus-Mediated Transfer of an Na + /K + -ATPase β 1 Subunit Gene Improves Alveolar Fluid Clearance and Survival in Hyperoxic Rats

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Claudins and alveolar epithelial barrier function in the lung

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Low Expression of Human Epithelial Sodium Channel in Airway Epithelium of Preterm Infants With Respiratory Distress

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Albumin activates the AKT signaling pathway and protects B-chronic lymphocytic leukemia cells from chlorambucil- and radiation-induced apoptosis

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In vitro proliferation and lifespan of human diploid fibroblasts in serum‐free BSA‐containing medium

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Trafficking of ENaC subunits in response to acute insulin in mouse kidney

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Overview of Albumin Physiology and its Role in Pediatric Diseases

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Comparison of Albumin Uptake in Rat Alveolar Type II and Type I-like Epithelial Cells in Primary Culture

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Growth of distal fetal rat lung epithelial cells in a defined serum-free medium

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Regulation of ENaC in mice lacking renal insulin receptors in the collecting duct

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Identification of different specificity requirements between SGK1 and PKBα

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FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages

Toh, W. H., Louber, J., Mahmoud, I. S., Chia, J., Bass, G., Dower, S., Verhagen, A. M., & Gleeson, P. A. (2019) · Journal of Cell Science · doi:10.1242/jcs.235416 · Cited by 42 · see citing works

Male Sex is Associated with a Reduced Alveolar Epithelial Sodium Transport

Kaltofen, T., Haase, M., Thome, U. H., & Laube, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136178 · Cited by 39 · see citing works

Novel Role of Rac1/WAVE Signaling Mechanism in Regulation of the Epithelial Na + Channel

Karpushev, A. V., Levchenko, V., Ilatovskaya, D. V., Pavlov, T. S., & Staruschenko, A. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.157784 · Cited by 37 · see citing works

SGK1 activity in Na+ absorbing airway epithelial cells monitored by assaying NDRG1-Thr346/356/366 phosphorylation

Inglis, S. K., Gallacher, M., Brown, S. G., McTavish, N., Getty, J., Husband, E. M., Murray, J. T., & Wilson, S. M. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0587-1 · Cited by 37 · see citing works

The Anti-Apoptotic Activity of Albumin for Endothelium Is Mediated by a Partially Cryptic Protein Domain and Reduced by Inhibitors of G-Coupled Protein and PI-3 Kinase, but Is Independent of Radical Scavenging or Bound Lipid

Bolitho, C., Bayl, P., Hou, J. Y., Lynch, G. W., Hassel, A. J., Wall, A. J., & Zoellner, H. F. (2007) · Journal of Vascular Research · doi:10.1159/000101777 · Cited by 34 · see citing works

Albumin Expands Albumin Reabsorption Capacity in Proximal Tubule Epithelial Cells through a Positive Feedback Loop between AKT and Megalin

Silva-Aguiar, R. P., Peruchetti, D. B., Florentino, L. S., Takiya, C. M., Marzolo, M., Dias, W. B., Pinheiro, A. A. S., & Caruso‐Neves, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020848 · Cited by 31 · see citing works

HDL-Holoparticle Uptake by Alveolar Type II Cells

Kolleck, I., Wissel, H., Guthmann, F., Schlame, M., Sinha, P. K., & Rüstow, B. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4774 · Cited by 30 · see citing works

Low-Affinity Transport of FITC-Albumin in Alveolar Type II Epithelial Cell Line RLE-6TN

Tagawa, M., Yumoto, R., Oda, K., Nagai, J., & Takano, M. (2008) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.23.318 · Cited by 26 · see citing works

Protein Kinase B Alpha (PKBα) Stimulates the Epithelial Sodium Channel (ENaC) Heterologously Expressed in Xenopus laevis Oocytes by Two Distinct Mechanisms

Diakov, A., Nesterov, V., Mokrushina, M., Rauh, R. D., & Korbmacher, C. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000324000 · Cited by 25 · see citing works

Glucocorticoids Distinctively Modulate the CFTR Channel with Possible Implications in Lung Development and Transition into Extrauterine Life

Laube, M., Bossmann, M., & Thome, U. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124833 · Cited by 20 · see citing works

Paracrine stimulation of perinatal lung functional and structural maturation by mesenchymal stem cells

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Amiloride-sensitive sodium current in evertedAmbystoma initial collecting tubule: short-term insulin effects

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Effects of peroxisome proliferator‐activated receptor γ agonists on Na+ transport and activity of the kinase SGK1 in epithelial cells from lung and kidney

Wilson, S. M., Mansley, M. K., Getty, J., Husband, E. M., Inglis, S. K., & Hansen, M. K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00564.x · Cited by 12 · see citing works

Epidermal growth factor strongly affects epithelial Na+ transport and barrier function in fetal alveolar cells, with minor sex-specific effects

Laube, M., Dornis, D., Wenzel, F., & Thome, U. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-95410-y · Cited by 10 · see citing works

Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Dexamethasone

Bossmann, M., Ackermann, B., Thome, U. H., & Laube, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081807 · Cited by 9 · see citing works

Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain

Howard, P. G., Zou, P., Zhang, Y., Huang, F., Tesic, V., Wu, C. Y.-C., & Lee, R. H.-C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114973 · Cited by 13 · see citing works

Developing an interpretable machine learning predictive model of chronic obstructive pulmonary disease by serum PFAS concentration

Shao, X., Zhang, L., Wang, Y., Ying, Y., & Chen, X. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1602566 · Cited by 6 · see citing works

Resveratrol alleviates blast lung injury by modulating the epithelial sodium channel (ENaC) via the PI3K/AKT pathway

Bai, Y., Ma, C., Jing, X., Wu, J., Yao, S., Tian, L., Dong, X., An, Z., & Ren, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113995 · Cited by 5 · see citing works

Serum albumin exposure enhances cell invasiveness and paclitaxel resistance in human neuroblastoma cells, with attenuation by valeriana‐type iridoid glycosides

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Inhalable lyophilized dry powder of tumor-targeted gefitinib-loaded albumin nanoparticles for non small cell lung cancer treatment

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Sodium Transport and Alveolar Fluid Clearance in Acute Lung Injury

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Rapid elevation of sodium transport through insulin is mediated by AKT in alveolar cells

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Transforming Growth Factor-β1 Decreases Expression of the Epithelial Sodium Channel αENaC and Alveolar Epithelial Vectorial Sodium and Fluid Transport via an ERK1/2-dependent Mechanism

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Pre-B-cell colony enhancing factor regulates the alveolar epithelial sodium-water transport system through the ERK and AKT pathways.

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Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury

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